Nicotinic control of dopamine release in nucleus accumbens (Maex et al. 2014)

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Minimal model of the VTA (ventral segmental area) representing two (GABA versus dopamine) neuron populations and two subtypes of nicotinic receptors (alpha4beta2 versus alpha7). The model is used to tell apart circuit from receptor mechanisms in the nicotinic control of dopamine release and its pharmacological manipulation.
1 . Maex R, Grinevich VP, Grinevich V, Budygin E, Bencherif M, Gutkin B (2014) Understanding the role a7 nicotinic receptors play in dopamine efflux in nucleus accumbens. ACS Chem Neurosci 5:1032-40 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neural mass; Channel/Receptor;
Brain Region(s)/Organism: Basal ganglia;
Cell Type(s): Ventral tegmental area dopamine neuron;
Gap Junctions:
Receptor(s): Nicotinic;
Transmitter(s): Acetylcholine; Dopamine; Gaba; Glutamate;
Simulation Environment: XPP;
Model Concept(s): Schizophrenia; Addiction; Volume transmission; Neuromodulation; Pathophysiology; Rate-coding model neurons; Simplified Models;
Implementer(s): Maex, Reinoud [reinoud at];
Search NeuronDB for information about:  Nicotinic; Acetylcholine; Dopamine; Gaba; Glutamate;
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