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Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
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Model Information
Model File
Citations
Accession:
230861
Network oscillations of different frequencies, durations and amplitudes are hypothesized to coordinate information processing and transfer across brain areas. Among these oscillations, hippocampal sharp wave-ripple complexes (SPW-Rs) are one of the most prominent. SPW-Rs occurring in the hippocampus are suggested to play essential roles in memory consolidation as well as information transfer to the neocortex. To-date, most of the knowledge about SPW-Rs comes from experimental studies averaging responses from neuronal populations monitored by conventional microelectrodes. In this work, we investigate spatiotemporal characteristics of SPW-Rs and how microelectrode size and distance influence SPW-R recordings using a biophysical model of hippocampus. We also explore contributions from neuronal spikes and synaptic potentials to SPW-Rs based on two different types of network activity. Our study suggests that neuronal spikes from pyramidal cells contribute significantly to ripples while high amplitude sharp waves mainly arise from synaptic activity. Our simulations on spatial reach of SPW-Rs show that the amplitudes of sharp waves and ripples exhibit a steep decrease with distance from the network and this effect is more prominent for smaller area electrodes. Furthermore, the amplitude of the signal decreases strongly with increasing electrode surface area as a result of averaging. The relative decrease is more pronounced when the recording electrode is closer to the source of the activity. Through simulations of field potentials across a high-density microelectrode array, we demonstrate the importance of finding the ideal spatial resolution for capturing SPW-Rs with great sensitivity. Our work provides insights on contributions from spikes and synaptic potentials to SPW-Rs and describes the effect of measurement configuration on LFPs to guide experimental studies towards improved SPW-R recordings.
Reference:
1 .
Canakci S, Toy MF, Inci AF, Liu X, Kuzum D (2017) Computational analysis of network activity and spatial reach of sharp wave-ripples.
PLoS One
12
:e0184542
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Realistic Network;
Brain Region(s)/Organism:
Hippocampus;
Cell Type(s):
Hippocampus CA1 pyramidal GLU cell;
Hippocampus CA1 basket cell;
Channel(s):
I Na,t;
I A;
I K;
I h;
Gap Junctions:
Gap junctions;
Receptor(s):
NMDA;
GabaA;
Glutamate;
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Oscillations;
Spatio-temporal Activity Patterns;
Implementer(s):
Canakci, Sadullah [scanakci at bu.edu];
Inci, Ahmet F [afinci at sabanciuniv,edu];
Toy, Faruk [faruk.toy at metu.edu.tr];
Liu, Xin [xil432 at end.ucsd.edu];
Kuzum, Duygu [dkuzum at eng.ucsd.edu];
Search NeuronDB
for information about:
Hippocampus CA1 pyramidal GLU cell
;
GabaA
;
NMDA
;
Glutamate
;
I Na,t
;
I A
;
I K
;
I h
;
/
CanakciEtAl2017
mod
ca1ih.mod
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Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
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ca1ika.mod
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ca1ikdr.mod
*
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High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
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Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
ca1ina.mod
*
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High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
caolmw.mod
*
Other models using caolmw.mod:
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
capr.mod
*
Other models using capr.mod:
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
edrive.mod
*
Other models using edrive.mod:
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
exp2synampa.mod
*
Other models using exp2synampa.mod:
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
exp2synampapre.mod
*
Other models using exp2synampapre.mod:
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
exp2synnmda.mod
*
Other models using exp2synnmda.mod:
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
exp2synnmdaperm.mod
*
Other models using exp2synnmdaperm.mod:
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
exp2synnmdapre.mod
*
Other models using exp2synnmdapre.mod:
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
fvpre.mod
*
Other models using fvpre.mod:
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
gap.mod
*
Other models using gap.mod:
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
halfgap.mod
*
Other models using halfgap.mod:
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
icaolmw.mod
*
Other models using icaolmw.mod:
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
icapr.mod
*
Other models using icapr.mod:
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
iholmkop.mod
*
Other models using iholmkop.mod:
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
iholmw.mod
*
Other models using iholmw.mod:
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
ihpyrkop.mod
*
Other models using ihpyrkop.mod:
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
kahppr.mod
*
Other models using kahppr.mod:
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
kaolmkop.mod
*
Other models using kaolmkop.mod:
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
kapyrkop.mod
*
Other models using kapyrkop.mod:
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
kcaolmw.mod
*
Other models using kcaolmw.mod:
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
kcpr.mod
*
Other models using kcpr.mod:
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
kdrbwb.mod
*
Other models using kdrbwb.mod:
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
kdrca1.mod
*
Other models using kdrca1.mod:
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
kdrolmkop.mod
*
Other models using kdrolmkop.mod:
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
kdrpr.mod
*
Other models using kdrpr.mod:
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
kdrpyrkop.mod
*
Other models using kdrpyrkop.mod:
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
na3n.mod
*
Other models using na3n.mod:
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
nafbwb.mod
*
Other models using nafbwb.mod:
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
nafolmkop.mod
*
Other models using nafolmkop.mod:
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
nafpr.mod
*
Other models using nafpr.mod:
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
nafpyrkop.mod
*
Other models using nafpyrkop.mod:
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
noisesyn.mod
par_ggap.mod
*
Other models using par_ggap.mod:
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
vecevent.mod
*
Other models using vecevent.mod:
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
Phase response curves firing rate dependency of rat purkinje neurons in vitro (Couto et al 2015)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Synaptic integration by MEC neurons (Justus et al. 2017)
Synthesis of spatial tuning functions from theta cell spike trains (Welday et al., 2011)
Synthesis of spatial tuning functions from theta cell spike trains (Welday et al., 2011)
xtra.mod
*
Other models using xtra.mod:
Direct recruitment of S1 pyramidal cells and interneurons via ICMS (Overstreet et al., 2013)
Direct recruitment of S1 pyramidal cells and interneurons via ICMS (Overstreet et al., 2013)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
Retinal ganglion cells responses and activity (Tsai et al 2012, Guo et al 2016)
Survey of electrically evoked responses in the retina (Tsai et al 2017)
aux_fun.inc
*
Other models using aux_fun.inc:
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
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