ModelDB: Specific inhibition of dendritic plateau potential in striatal projection neurons (Du et al 2017)

Specific inhibition of dendritic plateau potential in striatal projection neurons (Du et al 2017)

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Accession:231416

We explored dendritic plateau potentials in a biophysically detailed SPN model. We coupled the dendritic plateaus to different types of inhibitions (dendritic fast and slow inhibitions, perisomatic inhibition from FS interneurons , etc.) We found the inhibition provides precise control over the plateau potential, and thus the spiking output of SPNs.
Reference:
1 . Du K, Wu YW, Lindroos R, Liu Y, Rózsa B, Katona G, Ding JB, Kotaleski JH (2017) Cell-type-specific inhibition of the dendritic plateau potential in striatal spiny projection neurons. Proc Natl Acad Sci U S A 114:E7612-E7621 [PubMed]

Model Information (Click on a link to find other models with that property)

Model Type:	Dendrite; Channel/Receptor;
Brain Region(s)/Organism:	Striatum;
Cell Type(s):	Neostriatum spiny neuron;
Channel(s):	I A; I A, slow; Kir; I Calcium; I K,Ca; I L high threshold; I Na,p; I Na,t; I Q; I R; I K;
Gap Junctions:
Receptor(s):	AMPA; GabaA; NMDA;
Gene(s):	Cav3.2 CACNA1H;
Transmitter(s):	Glutamate; Gaba;
Simulation Environment:	GENESIS;
Model Concept(s):
Implementer(s):	Du, Kai [kai.du at ki.se];