Specific inhibition of dendritic plateau potential in striatal projection neurons (Du et al 2017)

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We explored dendritic plateau potentials in a biophysically detailed SPN model. We coupled the dendritic plateaus to different types of inhibitions (dendritic fast and slow inhibitions, perisomatic inhibition from FS interneurons , etc.) We found the inhibition provides precise control over the plateau potential, and thus the spiking output of SPNs.
1 . Du K, Wu YW, Lindroos R, Liu Y, Rózsa B, Katona G, Ding JB, Kotaleski JH (2017) Cell-type-specific inhibition of the dendritic plateau potential in striatal spiny projection neurons. Proc Natl Acad Sci U S A 114:E7612-E7621 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Dendrite; Channel/Receptor;
Brain Region(s)/Organism: Striatum;
Cell Type(s): Neostriatum spiny neuron;
Channel(s): I A; I A, slow; Kir; I Calcium; I K,Ca; I L high threshold; I Na,p; I Na,t; I Q; I R; I K;
Gap Junctions:
Receptor(s): AMPA; GabaA; NMDA;
Gene(s): Cav3.2 CACNA1H;
Transmitter(s): Glutamate; Gaba;
Simulation Environment: GENESIS;
Model Concept(s):
Implementer(s): Du, Kai [kai.du at ki.se];
Search NeuronDB for information about:  GabaA; AMPA; NMDA; I Na,p; I Na,t; I L high threshold; I A; I K; I K,Ca; I Calcium; I A, slow; I R; I Q; Kir; Gaba; Glutamate;
// genesis

float useAMPANMDAGHKchannels= 0  // we do not use GHK project for NMDA/AMPA

setclock 0 30e-6 //was 5e-6
        // Simulation time step (Second)       
setclock 1 2e-5        //  time step for ascii output
//setclock 1 1e-4 // time step for graphic output

// parameters for NMDA subunits

// NR2A
str	    subunit = "NR2C"
float   EkNMDA   = 0
float	Kmg       = 25
float	NMDAtau2      = (250e-3)/2 	//NR2A average from (Vicini et al., 1998 figure 1B)
float	NMDAgmax      = 0.325e-9      //NR2A and B from (Moyner et al., 1994 figure 7)
int ghk_yesno=0

str NMDAname = {subunit}

//for saving info on distal or proximal dendrites or massed and spaced. formula typeof dend, # of spines.

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