Specific inhibition of dendritic plateau potential in striatal projection neurons (Du et al 2017)

 Download zip file 
Help downloading and running models
Accession:231416
We explored dendritic plateau potentials in a biophysically detailed SPN model. We coupled the dendritic plateaus to different types of inhibitions (dendritic fast and slow inhibitions, perisomatic inhibition from FS interneurons , etc.) We found the inhibition provides precise control over the plateau potential, and thus the spiking output of SPNs.
Reference:
1 . Du K, Wu YW, Lindroos R, Liu Y, Rózsa B, Katona G, Ding JB, Kotaleski JH (2017) Cell-type-specific inhibition of the dendritic plateau potential in striatal spiny projection neurons. Proc Natl Acad Sci U S A 114:E7612-E7621 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Dendrite; Channel/Receptor;
Brain Region(s)/Organism: Striatum;
Cell Type(s): Neostriatum spiny neuron;
Channel(s): I A; I A, slow; Kir; I Calcium; I K,Ca; I L high threshold; I Na,p; I Na,t; I Q; I R; I K;
Gap Junctions:
Receptor(s): AMPA; GabaA; NMDA;
Gene(s): Cav3.2 CACNA1H;
Transmitter(s): Glutamate; Gaba;
Simulation Environment: GENESIS;
Model Concept(s):
Implementer(s): Du, Kai [kai.du at ki.se];
Search NeuronDB for information about:  GabaA; AMPA; NMDA; I Na,p; I Na,t; I L high threshold; I A; I K; I K,Ca; I Calcium; I A, slow; I R; I Q; Kir; Gaba; Glutamate;
/
MSN
MScell
channels
.directory
.goutputstream-A48NIW
.goutputstream-JLG4IW
ampa_channel.g *
BKKchannel.g
CaL12inact_channel.g
CaL13_channel.g
CaNinact_channel.g
CaR_channel.g
CaT_channel.g
gaba_channel.g
K_DR_channel.g
kAf_chanRE.g
kAs_chanKD.g
kAs_chanRE.g
kIR_chanKD.g
naF_chanOg.g
NaP_channel.g
nmda_channel.g *
SKchannelCaDep.g *
synaptic_channel.g *
tabchanforms.g *
                            
//genesis



//************************ Begin Primary Routine ******************************
//*****************************************************************************
function make_K_DR_channel
	//********************* Begin Local Variables ******************************
   float xmin = -0.1
   float xmax = 0.05
   int xdivs = 3000
   float x,dx,alpha_m,beta_m,tau_m,m_inf
   int i
   float  qfactor = 3    // 0.5   
   float Erev = -0.09    
	//********************* End Local Variables ********************************

 	if ({exists K_DR})
		echo "K_DR tabchannel exists"
   	return
 	end
 
 	create tabchannel K_DR 
  	setfield ^ Ek {Erev} 	\
             Gbar 100.0 	\ 
             Ik 0        	\
             Gk 0        	\
             Xpower 1    	\
             Ypower 0    	\
             Zpower 0 

  	call K_DR TABCREATE X {xdivs} {xmin} {xmax}
        dx = (xmax-xmin)/xdivs
        x = xmin
	echo "K_DR increment:" {dx} "V"
   for (i=0;i<={xdivs};i=i+1)

		/*migliore, et,al 1999 */
      alpha_m =1000.0*({exp {-110*(x+0.013)}} )
      beta_m  =1000.0*({exp {-80*(x+0.013)}}) 
      tau_m = {{0.001*50*beta_m/(1e3+alpha_m)}/qfactor}
      m_inf = 1000.0/(1000.0+alpha_m)
      setfield K_DR X_A->table[{i}] {tau_m}
      setfield K_DR X_B->table[{i}] {m_inf}
      x = x+dx
   end

   tweaktau K_DR X 
 
   setfield K_DR X_A->calc_mode 1 X_B->calc_mode 1
end
//************************ End Primary Routine ********************************
//*****************************************************************************

Loading data, please wait...