Specific inhibition of dendritic plateau potential in striatal projection neurons (Du et al 2017)

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Accession:231416
We explored dendritic plateau potentials in a biophysically detailed SPN model. We coupled the dendritic plateaus to different types of inhibitions (dendritic fast and slow inhibitions, perisomatic inhibition from FS interneurons , etc.) We found the inhibition provides precise control over the plateau potential, and thus the spiking output of SPNs.
Reference:
1 . Du K, Wu YW, Lindroos R, Liu Y, Rózsa B, Katona G, Ding JB, Kotaleski JH (2017) Cell-type-specific inhibition of the dendritic plateau potential in striatal spiny projection neurons. Proc Natl Acad Sci U S A 114:E7612-E7621 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Dendrite; Channel/Receptor;
Brain Region(s)/Organism: Striatum;
Cell Type(s): Neostriatum spiny neuron;
Channel(s): I A; I A, slow; Kir; I Calcium; I K,Ca; I L high threshold; I Na,p; I Na,t; I Q; I R; I K;
Gap Junctions:
Receptor(s): AMPA; GabaA; NMDA;
Gene(s): Cav3.2 CACNA1H;
Transmitter(s): Glutamate; Gaba;
Simulation Environment: GENESIS;
Model Concept(s):
Implementer(s): Du, Kai [kai.du at ki.se];
Search NeuronDB for information about:  GabaA; AMPA; NMDA; I Na,p; I Na,t; I L high threshold; I A; I K; I K,Ca; I Calcium; I A, slow; I R; I Q; Kir; Gaba; Glutamate; 
//genesis
//include_channels.g
/*******
AB: removed CaNNOINACT_channel and CaL12NOINACT_channel by combining with inactivating channels
AB: deleted CaQ because no evidence for such in SP, and doesn't contribute much anyway
AB: Also, removed KRP channels from here because we're not using them
AB: no longer making naP in the library since it is not used, and has been moved to a different directory
**********/

include MScell/channels/tabchanforms.g
//calcium channels
include MScell/channels/CaL12inact_channel
include MScell/channels/CaL13_channel
include MScell/channels/CaNinact_channel
//include MScell/channels/CaQ_channel
include MScell/channels/CaR_channel
include MScell/channels/CaT_channel

//voltage dependent channels
include MScell/channels/naF_chanOg
include MScell/channels/NaP_channel
include MScell/channels/kAf_chanRE
include MScell/channels/kIR_chanKD
include MScell/channels/kAs_chanRE
include MScell/channels/K_DR_channel

//calcium dependent potassium channels
include MScell/channels/BKKchannel
include MScell/channels/SKchannelCaDep

// NMDA/AMPA channel prototype taken from the old MS model
include MScell/ampa_channel_ghkCa
include MScell/nmda_channel_ghkCa
include MScell/channels/gaba_channel.g

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