Specific inhibition of dendritic plateau potential in striatal projection neurons (Du et al 2017)

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We explored dendritic plateau potentials in a biophysically detailed SPN model. We coupled the dendritic plateaus to different types of inhibitions (dendritic fast and slow inhibitions, perisomatic inhibition from FS interneurons , etc.) We found the inhibition provides precise control over the plateau potential, and thus the spiking output of SPNs.
1 . Du K, Wu YW, Lindroos R, Liu Y, Rózsa B, Katona G, Ding JB, Kotaleski JH (2017) Cell-type-specific inhibition of the dendritic plateau potential in striatal spiny projection neurons. Proc Natl Acad Sci U S A 114:E7612-E7621 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Dendrite; Channel/Receptor;
Brain Region(s)/Organism: Striatum;
Cell Type(s): Neostriatum spiny neuron;
Channel(s): I A; I A, slow; Kir; I Calcium; I K,Ca; I L high threshold; I Na,p; I Na,t; I Q; I R; I K;
Gap Junctions:
Receptor(s): AMPA; GabaA; NMDA;
Gene(s): Cav3.2 CACNA1H;
Transmitter(s): Glutamate; Gaba;
Simulation Environment: GENESIS;
Model Concept(s):
Implementer(s): Du, Kai [kai.du at ki.se];
Search NeuronDB for information about:  GabaA; AMPA; NMDA; I Na,p; I Na,t; I L high threshold; I A; I K; I K,Ca; I Calcium; I A, slow; I R; I Q; Kir; Gaba; Glutamate;

/*********************** Begin Local Subroutines *****************************/

	//************************ Begin function record_channel *******************
	function record_channel(compt,channel,xcell, color)
 		str compt,xcell,channel, color		
 		str path, graphic_path
		path = {neuronname}@"/"@{compt}@"/"@{channel}
		if ({channel}=="Ca_difshell_1"||{channel}=="Ca_difshell_2"||	\
			if( {isa difshell {path}})
				addmsg {neuronname}/{compt}/{channel} 							\
										{xcell}/Ca PLOT C  *	{channel}  *{color}
			elif( {isa Ca_concen {path}})
				addmsg {neuronname}/{compt}/{channel} 							\
										{xcell}/Ca PLOT Ca *{compt}  *{color}
			addmsg {neuronname}/{compt}/{channel} {xcell}/channels 			\
										PLOT Ik *{channel} *{color}
	//************************ End function record_channel *********************

	//************************ Begin function record_channel *******************
	function record_voltage (compt, xcell,color)
 		str compt, xcell, color
 		str path, spacer, graphic_path
		spacer = "        "
		//graphic_path = {compt}@{spacer}
    	addmsg {neuronname}/{compt} {xcell}/v PLOT Vm *{compt} *{color}
	//************************ End function record_channel *********************
	//************************ Begin function step_tmax ************************
	function step_tmax
   	setfield /cell/soma inject 0
   	step 5000
   	setfield /cell/soma inject {getfield /control/Injection value}
   	step 20000
   	setfield /cell/soma inject 0.0
	//************************ End function step_tmax **************************
	//************************ Begin function set_inject ***********************
	function set_inject(dialog)
    	str dialog
    	setfield /cell/soma inject {getfield {dialog} value}
	//************************ End function set_inject *************************
	//************************ Begin function overlaytoggle ********************
	function overlaytoggle(widget)
    	str widget
    	setfield /##[TYPE=xgraph] overlay {getfield {widget} state}
	//************************ End function overlaytoggle **********************
	//************************ Begin function add_overlay **********************
	function add_overlay
		create xtoggle /control/overlay   -script "overlaytoggle <widget>"
		setfield /control/overlay offlabel "Overlay OFF" onlabel "Overlay ON" \
																								state 0
	//************************ End function add_overlay ************************

/*********************** End Local Subroutines *******************************/

/*********************** Begin Externally Available Subroutines **************/

	//************************ Begin function make_control *********************
	function make_control
    	create xform /control [1050,0,250,145]
    	create xlabel /control/label -hgeom 25 -bg cyan -label "CONTROL PANEL"
    	create xbutton /control/RESET -wgeom 33%       -script reset
    	create xbutton /control/RUN  -xgeom 0:RESET -ygeom 0:label -wgeom 33% \
         -script step_tmax
    	create xbutton /control/QUIT -xgeom 0:RUN -ygeom 0:label -wgeom 34% 	 \
      	-script quit
    	create xdialog /control/Injection -label "Inject Amps" 					 \
         -value 304.95e-12 -script "set_inject <widget>"
    	xshow /control
	//************************ End function make_control ***********************

	//************************ Begin function make_graph ***********************	
	function make_graph
		str xcell = "/data"	
		float tmax = 0.6
		float xmin = 0.01
		create xform  /data [0,0,1000,1000]
		create xlabel /data/label [10,0,95%,25] 							\
			-label " MSN Cell"  													\
      	-fg    red

		create xgraph /data/v [10,10:label.bottom, 50%, 45%] 			\
      	-title "Memberaine Potential in the Soma"  					\
      	-bg    white

		create xgraph /data/syncurrents [10,10:v.bottom,50%,45%] 	\
      	-title "Synaptic currents"  										\
      	-bg    white 
		create xgraph /data/Ca [10:v.right,10:label.bottom,50%,45%] \
      	-title "Calcium Concentration: Calcium Buffer 3" 			\
      	-bg    white
		create xgraph /data/channels 											\
			[10:syncurrents.right,10:Ca.bottom,48%,45%] 					\
      	-title "Channel Currents: tertdend4/tert_dend5" 			\
      	-bg    white

		setfield /data/v      		xmin {xmin} xmax {tmax+0.01}   	\
											ymin -0.1 ymax 0.05
		setfield /data/Ca     		xmin {xmin} xmax {tmax+0.01}   	\
											ymin 4.5e-5 ymax 7e-5
		setfield /data/syncurrents xmax {tmax+0.8}  ymin 0 			\
											ymax 5.0e-12
		setfield /data/channels   	xmax {tmax+0.01}  ymin -1.2e-12 	\
											ymax 1.0e-13

  		useclock /data/v					 	1
  		useclock /data/Ca        			1 
  		useclock /data/channels  			1
		xshow /data

		//record voltage of the compartment
		record_voltage "tertdend4/tert_dend5" {xcell} "blue" 	                   
		record_voltage soma {xcell} "red"  

		record_channel "tertdend4/tert_dend5" KAsI_channel 	{xcell} "blue"
		record_channel "tertdend4/tert_dend5" KAsII_channel	{xcell}  "red"
		record_channel "tertdend4/tert_dend5" KIR_channel   	{xcell}  "black"
		record_channel "tertdend4/tert_dend5" KAf_channel   	{xcell}  "green"
		record_channel soma 			{CA_BUFF_3}		{xcell}  "blue"
		record_channel primdend4 	{CA_BUFF_3} 	{xcell}  "black"
		record_channel secdend6 	{CA_BUFF_3} 	{xcell}  "red"
		record_channel tertdend4 	{CA_BUFF_3} 	{xcell}  "green"


	//************************ End function make_graph *************************
/*********************** End Externally Available Subroutines ****************/

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