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Thalamocortical Relay cell under current clamp in high-conductance state (Zeldenrust et al 2018)
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Accession:
232876
Mammalian thalamocortical relay (TCR) neurons switch their firing activity between a tonic spiking and a bursting regime. In a combined experimental and computational study, we investigated the features in the input signal that single spikes and bursts in the output spike train represent and how this code is influenced by the membrane voltage state of the neuron. Identical frozen Gaussian noise current traces were injected into TCR neurons in rat brain slices to adjust, fine-tune and validate a three-compartment TCR model cell (Destexhe et al. 1998, accession number 279). Three currents were added: an h-current (Destexhe et al. 1993,1996, accession number 3343), a high-threshold calcium current and a calcium- activated potassium current (Huguenard & McCormick 1994, accession number 3808). The information content carried by the various types of events in the signal as well as by the whole signal was calculated. Bursts phase-lock to and transfer information at lower frequencies than single spikes. On depolarization the neuron transits smoothly from the predominantly bursting regime to a spiking regime, in which it is more sensitive to high-frequency fluctuations. Finally, the model was used to in the more realistic “high-conductance state” (Destexhe et al. 2001, accession number 8115), while being stimulated with a Poisson input (Brette et al. 2007, Vogels & Abbott 2005, accession number 83319), where fluctuations are caused by (synaptic) conductance changes instead of current injection. Under “standard” conditions bursts are difficult to initiate, given the high degree of inactivation of the T-type calcium current. Strong and/or precisely timed inhibitory currents were able to remove this inactivation.
References:
1 .
Zeldenrust F, Chameau P, Wadman WJ (2018) Spike and burst coding in thalamocortical relay cells.
PLoS Comput Biol
14
:e1005960
[
PubMed
]
2 .
Destexhe A, Bal T, McCormick DA, Sejnowski TJ (1996) Ionic mechanisms underlying synchronized oscillations and propagating waves in a model of ferret thalamic slices.
J Neurophysiol
76
:2049-70
[
PubMed
]
3 .
Huguenard JP, Mccormick DA (1994)
Electrophysiology of the Neuron: An Interactive Tutorial
4 .
Destexhe A, Rudolph M, Fellous JM, Sejnowski TJ (2001) Fluctuating synaptic conductances recreate in vivo-like activity in neocortical neurons.
Neuroscience
107
:13-24
[
PubMed
]
5 .
Brette R, Rudolph M, Carnevale T, Hines M, Beeman D, Bower JM, Diesmann M, Morrison A, Goodman PH, Harris FC, Zirpe M, Natschläger T, Pecevski D, Ermentrout B, Djurfeldt M, Lansner A, Rochel O, Vieville T, Muller E, Davison AP, El Boustani S, Destexhe A (2007) Simulation of networks of spiking neurons: a review of tools and strategies.
J Comput Neurosci
23
:349-98
[
PubMed
]
6 .
Vogels TP, Abbott LF (2005) Signal propagation and logic gating in networks of integrate-and-fire neurons.
J Neurosci
25
:10786-95
[
PubMed
]
7 .
Destexhe A, Neubig M, Ulrich D, Huguenard J (1998) Dendritic low-threshold calcium currents in thalamic relay cells.
J Neurosci
18
:3574-88
[
PubMed
]
8 .
Destexhe A, Babloyantz A, Sejnowski TJ (1993) Ionic mechanisms for intrinsic slow oscillations in thalamic relay neurons.
Biophys J
65
:1538-52
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Thalamus;
Cell Type(s):
Thalamus geniculate nucleus/lateral principal GLU cell;
Channel(s):
I L high threshold;
I K,Ca;
I h;
I T low threshold;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Bursting;
Information transfer;
Rebound firing;
Sensory coding;
Implementer(s):
Zeldenrust, Fleur [fleurzeldenrust at gmail.com];
Search NeuronDB
for information about:
Thalamus geniculate nucleus/lateral principal GLU cell
;
I L high threshold
;
I T low threshold
;
I h
;
I K,Ca
;
/
TCR
influence_ih_iT
cells
cadecay.mod
*
Other models using cadecay.mod:
A Model Circuit of Thalamocortical Convergence (Behuret et al. 2013)
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
Thalamocortical Relay cell under current clamp in high-conductance state (Zeldenrust et al 2018)
Thalamocortical Relay cell under current clamp in high-conductance state (Zeldenrust et al 2018)
hh2.mod
*
Other models using hh2.mod:
A Model Circuit of Thalamocortical Convergence (Behuret et al. 2013)
Inferring connection proximity in electrically coupled networks (Cali et al. 2007)
Low Threshold Calcium Currents in TC cells (Destexhe et al 1998)
Pyramidal Neuron: Deep, Thalamic Relay and Reticular, Interneuron (Destexhe et al 1998, 2001)
T channel currents (Vitko et al 2005)
T channel currents (Vitko et al 2005)
T channel currents (Vitko et al 2005)
Thalamic reticular neurons: the role of Ca currents (Destexhe et al 1996)
Thalamocortical Relay cell under current clamp in high-conductance state (Zeldenrust et al 2018)
Thalamocortical Relay cell under current clamp in high-conductance state (Zeldenrust et al 2018)
ic.mod
*
Other models using ic.mod:
MyFirstNEURON (Houweling, Sejnowski 1997)
Thalamic neuron: Modeling rhythmic neuronal activity (Meuth et al. 2005)
Thalamic neuron: Modeling rhythmic neuronal activity (Meuth et al. 2005)
Thalamocortical Relay cell under current clamp in high-conductance state (Zeldenrust et al 2018)
Thalamocortical Relay cell under current clamp in high-conductance state (Zeldenrust et al 2018)
Ih_des93.mod
*
Other models using Ih_des93.mod:
Knox implementation of Destexhe 1998 spike and wave oscillation model (Knox et al 2018)
Thalamocortical Relay cell under current clamp in high-conductance state (Zeldenrust et al 2018)
Thalamocortical Relay cell under current clamp in high-conductance state (Zeldenrust et al 2018)
Thalamocortical and Thalamic Reticular Network (Destexhe et al 1996)
il.mod
*
Other models using il.mod:
Cortical pyramidal neuron, phase response curve (Stiefel et al 2009)
MyFirstNEURON (Houweling, Sejnowski 1997)
Thalamic neuron: Modeling rhythmic neuronal activity (Meuth et al. 2005)
Thalamic neuron: Modeling rhythmic neuronal activity (Meuth et al. 2005)
Thalamocortical Relay cell under current clamp in high-conductance state (Zeldenrust et al 2018)
Thalamocortical Relay cell under current clamp in high-conductance state (Zeldenrust et al 2018)
ITGHK.mod
*
Other models using ITGHK.mod:
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
Thalamocortical Relay cell under current clamp in high-conductance state (Zeldenrust et al 2018)
Thalamocortical Relay cell under current clamp in high-conductance state (Zeldenrust et al 2018)
VClamp.mod
*
Other models using VClamp.mod:
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
Low Threshold Calcium Currents in TC cells (Destexhe et al 1998)
T channel currents (Vitko et al 2005)
T channel currents (Vitko et al 2005)
T channel currents (Vitko et al 2005)
Thalamic reticular neurons: the role of Ca currents (Destexhe et al 1996)
Thalamocortical Relay cell under current clamp in high-conductance state (Zeldenrust et al 2018)
Thalamocortical Relay cell under current clamp in high-conductance state (Zeldenrust et al 2018)
El.oc
*
Other models using El.oc:
Low Threshold Calcium Currents in TC cells (Destexhe et al 1998)
T channel currents (Vitko et al 2005)
T channel currents (Vitko et al 2005)
T channel currents (Vitko et al 2005)
Thalamic reticular neurons: the role of Ca currents (Destexhe et al 1996)
Thalamocortical Relay cell under current clamp in high-conductance state (Zeldenrust et al 2018)
Thalamocortical Relay cell under current clamp in high-conductance state (Zeldenrust et al 2018)
loc3.oc
*
Other models using loc3.oc:
Low Threshold Calcium Currents in TC cells (Destexhe et al 1998)
Thalamocortical Relay cell under current clamp in high-conductance state (Zeldenrust et al 2018)
Thalamocortical Relay cell under current clamp in high-conductance state (Zeldenrust et al 2018)
stim_long.dat
*
Other models using stim_long.dat:
Thalamocortical Relay cell under current clamp in high-conductance state (Zeldenrust et al 2018)
tc3_cc_ihiT.hoc
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