#define OSC 1 // 1: Delta; 2: Spindle; 3: Alpha; 4: Gamma
// Simulation time
#define t_end 3000.0 // Delta: 3000 ms; Alpha and Gamma: 2000 ms; Spindle: 4000 ms
// When stimulation is applied, the simulation time is 52000 ms if 1-50 Hz is simulated
// Stimulation Input
#define FLAG_STIMULATION_LGN_PULSE 0 // 0: No stimulation; 1: Pulsatile input to LGN
#define FLAG_STIMULATION_TRN_PULSE 0 // 0: No stimulation; 1: Pulsatile input to TRN
#define STIM_START_TIME 1000 // Stimulation start time
#define STIM_DURATION 1000000 // The maximal stimulation time
#define STIM_STEP_DURATION 1000 // Stimulation step duration
#define PULSE_ON_DURATION 10 // Pulse duration
#define STIM_MAX_F 50 // Maximal stimulation frequency
#define STIM_F0 0 // Initial frequency
#define STIM_F_INCREMENT 1 // Stimulation increment step
#define STIM_AMP 0.1 // Stimulation amplitude in nA
// Spindle-triggering inputs
#define SPIN_T0 1000 // Onset time of spindle-triggering input
#define SPIN_TT 100 // Spindle-triggering input duration
#define SPIN_F 0.1 // Spindle triggering input frequency
#define SPIN_AMP 0.1 // Spindle triggering input amplitude
#define SPIN_X 10 // Subset of RE_X receiving spindle-triggering input
#define SPIN_Y 10 // Subset of RE_Y receiving spindle-triggering input
// Random seed
#define RAND_SEED 100
#define PI 3.14159
// Current injection
#define FLAG_CURRENT_INJECTION 0
// Random Background Inputs
#define FLAG_RANDOM_INPUT 1
#define RANDOM_F_TC 0.1 // Random input frequency; 0.1 per ms (100 Hz)
#define N_INPUT_TC1 1 // Number of random background input
#define N_INPUT_TC2 1
// Reversal potential
#define ENA 50
#define EK -90
#define E_GABA_RE -70
// Short-term depression parameters
#define TAU_STD 700
#define F_USE_SPIKE 0.07
// Connection ON/OFF
#define FLAG_TC1_TC1_GAP 1
#define FLAG_TC2_TC1_GAP 1
#define FLAG_RE_RE_GAP 1
#define FLAG_TC1_IN 1
#define FLAG_IN_TC2 1
#define FLAG_RE_IN 1
#define FLAG_RE_RE 1
#define FLAG_TC1_RE 1
#define FLAG_TC2_RE 1
#define FLAG_RE_TC1 1
#define FLAG_RE_TC2 1
#define FLAG_TC2_TC2 0 // The RTC-RTC connections are not active !
// Connection probability
#define P_TC1_TC1_GAP 0.3
#define P_TC2_TC1_GAP 0.3
#define P_RE_RE_GAP 0.3
#define P_TC2_GAP 0.2 // Percentage of RTCs that have gap junctions with HTCs
#define P_RE_GAP 0.2 // Percentage of REs that have gap junctions with other REs
#define P_TC1_IN 0.3
#define P_IN_TC2 0.3
#define P_TC1_RE 0.2
#define P_TC2_RE 0.2
#define P_RE_TC1 0.2
#define P_RE_TC2 0.2
#define P_RE_RE 0.2
#define P_RE_IN 0.05
#define P_TC2_TC2 0.2
// Turn STD ON/OFF
#define STD_TC1_IN 1
#define STD_IN_TC2 1
#define STD_RE_IN 1
#define STD_RE_RE 1
#define STD_TC1_RE 1
#define STD_TC2_RE 1
#define STD_RE_TC1 1
#define STD_RE_TC2 1
#define STD_TC2_TC2 0
// Gap junctional resistance
#define R_TC1_TC1 100 // in MOhm
#define R_TC1_TC2 300 // in MOhm
#define R_RE_RE 300 // in MOhm
#define D_TC1_TC1 2 // Radius of the gap junctions
#define D_TC2_TC1 2
#define D_TC2_TC2 2
#define D_RE_RE 2
// Maximal conductance
#define g_AMPA_TC1_IN 0.006 // (in uS)
#define g_NMDA_TC1_IN 0.003 // (in uS)
#define g_AMPA_TC1_RE 0.004
#define g_NMDA_TC1_RE 0.002
#define g_AMPA_TC2_RE 0.004
#define g_NMDA_TC2_RE 0.002
#define g_AMPA_TC2_TC2 0.002
#define g_NMDA_TC2_TC2 0.001
// GABA
#define g_GABA_RE_TC2 0.003
#define g_GABA_RE_TC1 0.003
#define g_GABA_IN_TC2 0.003
#define g_GABA_RE_IN 0.001
#define g_GABA_RE_RE 0.001
//====================================================================
// Leakage conductance at different states
//====================================================================
// HTC
#define GL1_TC1 0.0075 // lower bound of the regular leak
#define GL2_TC1 0.0125 // upper bound of the regular leak
#define GKL_TC1_S1 0.035 // potassium leak in Delta (Low ACh/NE)
#define GKL_TC1_S2 0.01 // potassium leak in Spindle (Medium ACh/NE)
#define GKL_TC1_S3 0.0 // potassium leak in Alpha/Gamma (High ACh/NE)
// RTC
#define GL1_TC2 0.0075
#define GL2_TC2 0.0125
#define GKL_TC2_S1 0.035 // potassium leak in Delta
#define GKL_TC2_S2 0.01 // potassium leak in Spindle
#define GKL_TC2_S3 0.0 // potassium leak in Alpha/Gamma
// IN
#define GL1_IN 0.0075
#define GL2_IN 0.0125
#define GKL_IN_S1 0.01 // potassium leak in Delta
#define GKL_IN_S2 0.015 // potassium leak in Spindle
#define GKL_IN_S3 0.02 // potassium leak in Alpha/Gamma
// RE
#define GL1_RE 0.0075
#define GL2_RE 0.0125
#define GKL_RE_S1 0.03 // potassium leak in Delta
#define GKL_RE_S2 0.02 // potassium leak in Spindle
#define GKL_RE_S3 0.01 // potassium leak in Alpha/Gamma
//=============================================================
// Cell numbers
//=============================================================
#define TC1_EX 1
#define TC2_EX 1
#define IN_EX 1
#define RE_EX 1
// HTC cells
#define N_TC1_X 7 // Cell number in the x direction
#define N_TC1_Y 7 // Cell number in the y direction
#define N_TC1 (N_TC1_X*N_TC1_Y) // Total number of HTC cells
// RTC cells
#define N_TC2_X 12
#define N_TC2_Y 12
#define N_TC2 (N_TC2_X*N_TC2_Y)
// Interneurons
#define N_IN_X 8
#define N_IN_Y 8
#define N_IN (N_IN_X*N_IN_Y)
// RE cells
#define N_RE_X 10
#define N_RE_Y 10
#define N_RE (N_RE_X*N_RE_Y)
/*******************************************************************
// Number of equations
*******************************************************************/
// Number of ODEs for each cell type
#define EQ_TC 14
#define EQ_IN 10
#define EQ_RE 9
#define N_EQ_TC1 (EQ_TC * N_TC1)
#define N_EQ_TC2 (EQ_TC * N_TC2)
#define N_EQ_IN (EQ_IN * N_IN)
#define N_EQ_RE (EQ_RE * N_RE)
#define N_EQ N_EQ_TC1 + N_EQ_TC2 + N_EQ_IN + N_EQ_RE
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