/**** This is from the Wolf et al. (2005) modelDB entry.
** Copied here to the Rumbell optimization code.
**
** cmw 9/1/16
**
*****/
//****************************************************************************
// These are the default parameters for creation of the MSP cell. This file
// is usually called by hoc/nacb_main.hoc
cai0_ca_ion = 0.001 // mM, Churchill 1998
cao0_ca_ion = 5 // mM, Churchill 1998 - gives eca = 100 mV
cali0_cal_ion = 0.001 // mM, Churchill 1998
calo0_cal_ion = 5 // mM, Churchill 1998 - gives eca = 100 mV
celsius = 22 // degC
global_ra = 100 // not really sure what this is
RA = 100 // ohm-cm - constant for whole cell
CM = 0.96563845 // uF-cm2 - constant for whole cell
G_PAS = 0.0001437 // S/cm2
E_PAS = -79.2586 // mV
G_NAF = 3.5526529495 // soma only
G_NAFD = 0.0195 // all dends
G_NAP = 0.0003926929// soma only
G_NAPD = 1.3802e-7 // all dends, according to Wolf et al. paper
//G_NAPD = 1.3802e-6 // all dends -- CHANGED in Wolf modelDB entry
G_KIR = 0.00014 // S/cm2
G_KAS = 0.0038245948 // soma & prox dends; s/cm2
G_KASD = 0.00095142 // mid & distal dends; S/cm2
G_KAF = 0.0789485208 // soma & prox dends; S/cm2
G_KAFD = 0.020584 // mid & dist dends; S/cm2
G_BKKCA = 0.0031 //
G_SKKCA = 0.084
G_KDR = 0.0000796449
G_KDR_AIS = 0.0062194784
G_NAF_AIS = 0.2829563051 // different values allowed in axon initial segment
G_KAS_AIS = 0.0208
G_KAF_AIS = 0.0071847962
G_NAP_AIS = 0.004885817
CAINF = 1e-5 // mM, steady state intracell ca conc.
TAUR = 43 // ms, time const of ca diffusion - Jackson 2003
CA_DRIVE = 10000
CA_PUMP = 0.05
caNMDA = 0.1
P_CAL = 7.424e-7 // cm/s
P_CAL13 = 1.8e-7 //1.7e-6 // cm/s
P_CAN = 2.541e-07 // cm/s
P_CAQ = 0 // cm/s
P_CAR = 8.426e-07 // cm/s
P_CAT = 1.154e-07 // cm/s 4e-7
newEK = -94
ENA = 50
NET_N = 1e10
G_AMPA = 8.5e-4 //350e-6 //8.81e-4
G_NMDA = 12.2e-5 // 9.2e-5
G_GABA = 0.0021 //4300e-6 //0.0027
AMPA_WT = 1
NMDA_WT = 1
GABA_WT = 1
NOISE = 1
NGLU = 126
NGABA = 118
NSYN = NGABA + NGLU
mshift_na = 6.6594
hshift_na = 0.52039
ashift_k = 13.605
bshift_k = 0.33739
mshift_ka = 10.801
hshift_ka = 14.848
mshift_ca = 9.163
hshift_ca = 11.819
HTAUSHIFT_KAS = -88
// factors for adding the Hay axon
CM_MYELINFAC = 0.02 // Hay myelin had cm=0.02, cm=1 in AIS/soma
AXON_MSHIFT = 10
AXON_HSHIFT = 5
AXON_MSLOPEFAC = 1.29 // Hay NaT m_slope was 9/mV in axon, 7/mV in soma
SOMA_MVHALF_NAF = -23.9
SOMA_MSLOPE_NAF = -11.8
SOMA_MSHIFT_NAF = 0
SOMA_HVHALF_NAF = -62.9
SOMA_HSLOPE_NAF = 10.7
SOMA_HSHIFT_NAF = 0
/****************************************************************************
//
// These values were optimized by Hanbing's runs on 3/18/17 (and followed up by christina), including the -170 and -220 pA injections, and optimizing the KIR kinetics. The morphology (dend, soma, axon) is updated, as is the EK value.
//
// Results emailed to me from Hanbing, run on redrocks.
when EK=-90, this gave a good fit:
490 0.0001365906696078 -80.9547669379664967 1.0660721294525504 0.0076461218561479 0.2002160297856376 107.2005009815930237 14.9992977215247709 0.16
and when EK=-94:
581 0.0001509364628840 -79.7237135538248225 0.9678596364433903 0.0076007689969894 0.3271353165413586 106.0772946544010722 14.9947079698156163 0.19
************************************/
G_PAS = 0.000001
E_PAS = -89.9999984228
CM = 0.9
G_KIR = 0.0000602945
QKIR = 0.2
SHKIR = 44.390512
SLPKIR = 14.99999
//dgkaf = 0.0012340247
V0 = -80
P_CAQ = 0 // cm/s - turn this off, Evans excluded it.
// note, we will include NaP in this optimization due to the axon inclusion.
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