"There have been few quantitative characterizations of the
morphological, biophysical, and cable properties of neurons in the
human neocortex. We employed feature-based statistical methods on a
rare data set of 60 3D reconstructed pyramidal neurons from L2 and L3
in the human temporal cortex (HL2/L3 PCs) removed after brain
surgery. Of these cells, 25 neurons were also characterized
physiologically. Thirty-two morphological features were analyzed
(e.g., dendritic surface area, 36 333 ± 18 157 µm2; number of basal
trees, 5.55 ± 1.47; dendritic diameter, 0.76 ± 0.28 µm).
...
A novel descriptor for apical dendritic
topology yielded 2 distinct classes, termed hereby as “slim-tufted”
and “profuse-tufted” HL2/L3 PCs; the latter class tends to fire at
higher rates. Thus, our morpho-electrotonic analysis shows 2 distinct
classes of HL2/L3 PCs."
Reference:
1 .
Deitcher Y, Eyal G, Kanari L, Verhoog MB, Atenekeng Kahou GA, Mansvelder HD, de Kock CPJ, Segev I (2017) Comprehensive Morpho-Electrotonic Analysis Shows 2 Distinct Classes of L2 and L3 Pyramidal Neurons in Human Temporal Cortex. Cereb Cortex 27:5398-5414 [PubMed]
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