A model of neurovascular coupling and the BOLD response (Mathias et al 2017, Kenny et al 2018)

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Here a lumped parameter numerical model of a neurovascular unit is presented, representing an intercellular communication system based on ion exchange through pumps and channels between neurons, astrocytes, smooth muscle cells, endothelial cells, and the spaces between these cells: the synaptic cleft between the neuron and astrocyte, the perivascular space between the astrocyte and SMC, and the extracellular space surrounding the cells. The model contains various cellular and chemical pathways such as potassium, astrocytic calcium, and nitric oxide. The model is able to simulate neurovascular coupling, the process characterised by an increase in neuronal activity followed by a rapid dilation of local blood vessels and hence increased blood supply providing oxygen and glucose to cells in need. The model also incorporates the BOLD response.
1 . Mathias EJ, Plank MJ, David T (2017) A model of neurovascular coupling and the BOLD response: PART I. Comput Methods Biomech Biomed Engin 20:508-518 [PubMed]
2 . Kenny A, Plank MJ, David T (2018) The role of astrocytic calcium and TRPV4 channels in neurovascular coupling. J Comput Neurosci 44:97-114 [PubMed]
3 . Dormanns K, Brown RG, David T (2016) The role of nitric oxide in neurovascular coupling. J Theor Biol 394:1-17 [PubMed]
4 . Dormanns K, van Disseldorp EM, Brown RG, David T (2015) Neurovascular coupling and the influence of luminal agonists via the endothelium. J Theor Biol 364:49-70 [PubMed]
5 . Farr H, David T (2011) Models of neurovascular coupling via potassium and EET signalling. J Theor Biol 286:13-23 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type:
Brain Region(s)/Organism: Hippocampus;
Cell Type(s):
Gap Junctions:
Transmitter(s): Glutamate; NO; Ions;
Simulation Environment: MATLAB;
Model Concept(s): Action Potential Initiation; Calcium dynamics; Potassium buffering;
Implementer(s): Kenny, Allanah [allanah.kenny at pg.canterbury.ac.nz]; Mathias, Elshin ; Dormanns, Katharina ; David, Tim ;
Search NeuronDB for information about:  NO; Glutamate; Ions;
Object-oriented implementation of the original NVU (envy-you) model and code.

Branch: NVU 2.0

NVU 2.0
Contains the following components:
* Extracellular space compartment
* Astrocytic calcium pathway with EETs
* TRPV4 channel on the astrocytic endfoot
* Nitric oxide pathway
* Neuron (soma/axon and dendrite compartments) with input current

The code is run in Matlab:
1) To solve the system use the script nvu_run_script.m
2) To quickly plot all variables use the script plot_all_variables.m 

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