Optimal synaptic assignment for locomotory behavior in C. elegans (Rakowski & Karbowski 2017)

Help downloading and running models
"The detailed knowledge of C. elegans connectome for 3 decades has not contributed dramatically to our understanding of worm’s behavior. One of main reasons for this situation has been the lack of data on the type of synaptic signaling between particular neurons in the worm’s connectome. The aim of this study was to determine synaptic polarities for each connection in a small pre-motor circuit controlling locomotion. Even in this compact network of just 7 neurons the space of all possible patterns of connection types (excitation vs. inhibition) is huge. To deal effectively with this combinatorial problem we devised a novel and relatively fast technique based on genetic algorithms and large-scale parallel computations, which we combined with detailed neurophysiological modeling of interneuron dynamics and compared the theory to the available behavioral data. As a result of these massive computations, we found that the optimal connectivity pattern that matches the best locomotory data is the one in which all interneuron connections are inhibitory, even those terminating on motor neurons. ..."
1 . Rakowski F, Karbowski J (2017) Optimal synaptic signaling connectome for locomotory behavior in Caenorhabditis elegans: Design minimizing energy cost. PLoS Comput Biol 13:e1005834 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse;
Brain Region(s)/Organism:
Cell Type(s):
Gap Junctions:
Transmitter(s): Acetylcholine;
Simulation Environment: Java (web link to model); Mathematica (web link to model);
Model Concept(s): Invertebrate;
Implementer(s): Rakowski, Franciszek ;
Search NeuronDB for information about:  Acetylcholine;
(located via links below)
# An example hook script to verify what is about to be committed.
# Called by "git commit" with no arguments.  The hook should
# exit with non-zero status after issuing an appropriate message if
# it wants to stop the commit.
# To enable this hook, rename this file to "pre-commit".

if git rev-parse --verify HEAD >/dev/null 2>&1
	# Initial commit: diff against an empty tree object

# If you want to allow non-ASCII filenames set this variable to true.
allownonascii=$(git config --bool hooks.allownonascii)

# Redirect output to stderr.
exec 1>&2

# Cross platform projects tend to avoid non-ASCII filenames; prevent
# them from being added to the repository. We exploit the fact that the
# printable range starts at the space character and ends with tilde.
if [ "$allownonascii" != "true" ] &&
	# Note that the use of brackets around a tr range is ok here, (it's
	# even required, for portability to Solaris 10's /usr/bin/tr), since
	# the square bracket bytes happen to fall in the designated range.
	test $(git diff --cached --name-only --diff-filter=A -z $against |
	  LC_ALL=C tr -d '[ -~]\0' | wc -c) != 0
	cat <<\EOF
Error: Attempt to add a non-ASCII file name.

This can cause problems if you want to work with people on other platforms.

To be portable it is advisable to rename the file.

If you know what you are doing you can disable this check using:

  git config hooks.allownonascii true
	exit 1

# If there are whitespace errors, print the offending file names and fail.
exec git diff-index --check --cached $against --

Loading data, please wait...