Optimal synaptic assignment for locomotory behavior in C. elegans (Rakowski & Karbowski 2017)

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"The detailed knowledge of C. elegans connectome for 3 decades has not contributed dramatically to our understanding of worm’s behavior. One of main reasons for this situation has been the lack of data on the type of synaptic signaling between particular neurons in the worm’s connectome. The aim of this study was to determine synaptic polarities for each connection in a small pre-motor circuit controlling locomotion. Even in this compact network of just 7 neurons the space of all possible patterns of connection types (excitation vs. inhibition) is huge. To deal effectively with this combinatorial problem we devised a novel and relatively fast technique based on genetic algorithms and large-scale parallel computations, which we combined with detailed neurophysiological modeling of interneuron dynamics and compared the theory to the available behavioral data. As a result of these massive computations, we found that the optimal connectivity pattern that matches the best locomotory data is the one in which all interneuron connections are inhibitory, even those terminating on motor neurons. ..."
1 . Rakowski F, Karbowski J (2017) Optimal synaptic signaling connectome for locomotory behavior in Caenorhabditis elegans: Design minimizing energy cost. PLoS Comput Biol 13:e1005834 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse;
Brain Region(s)/Organism:
Cell Type(s):
Gap Junctions:
Transmitter(s): Acetylcholine;
Simulation Environment: Java (web link to model); Mathematica (web link to model);
Model Concept(s): Invertebrate;
Implementer(s): Rakowski, Franciszek ;
Search NeuronDB for information about:  Acetylcholine;
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# An example hook script to prepare the commit log message.
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# To enable this hook, rename this file to "prepare-commit-msg".

# This hook includes three examples.  The first comments out the
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# The third example adds a Signed-off-by line to the message, that can
# still be edited.  This is rarely a good idea.

case "$2,$3" in
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# grep -qs "^$SOB" "$1" || echo "$SOB" >> "$1"

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