Advanced search
SenseLab
SimToolDB
ModelDB Help
User account
Login
Register
Find models by
Model name
First author
Each author
Region(circuits)
Find models for
Cell type
Current
Receptor
Gene
Transmitters
Concept
Simulators
Methods
Find models of
Realistic Networks
Neurons
Electrical synapses (gap junctions)
Chemical synapses
Ion channels
Neuromuscular junctions
Axons
Pathophysiology
Other resources
SenseLab mailing list
ModelDB related resources
Computational neuroscience ecosystem
Models in a git repository
Locational influence of dendritic PIC on input-output properties of spinal motoneurons (Kim 2017)
 
Download zip file
Help downloading and running models
Model Information
Model File
Citations
Accession:
239039
How does the dendritic location of calcium persistent inward current (Ca-PIC) influence dendritic excitability and firing behavior across the spinal motoneuron pool? This issue was investigated developing a model motoneuron pool where model parameters were analytically determined to reflect key motoneuron type-specific properties experimentally identified. The simulation results point out the negative relationship between the distance of Ca-PIC source from the soma and cell recruitment threshold as a basis underlying the systematic variation in input-output properties of motoneurons over the motoneuron pool.
References:
1 .
Kim H (2017) Impact of the localization of dendritic calcium persistent inward current on the input-output properties of spinal motoneuron pool: a computational study.
J Appl Physiol (1985)
123
:1166-1187
[
PubMed
]
2 .
Kim H, Jones KE, Heckman CJ (2014) Asymmetry in signal propagation between the soma and dendrites plays a key role in determining dendritic excitability in motoneurons.
PLoS One
9
:e95454
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Spinal cord lumbar motor neuron alpha ACh cell;
Channel(s):
I Calcium;
I Potassium;
I Sodium;
I_AHP;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:
XPP;
Model Concept(s):
Active Dendrites;
Implementer(s):
Kim, Hojeong [hojeong.kim03 at gmail.com];
Search NeuronDB
for information about:
Spinal cord lumbar motor neuron alpha ACh cell
;
I Sodium
;
I Calcium
;
I Potassium
;
I_AHP
;
Download the displayed file
/
Kim2017
README.html
fig3a.ode
fig3b.ode
fig3c.ode
fig3d.ode
screenshot1.png
screenshot2.png
screenshot3.png
screenshot4.png
Table1.xls
Loading data, please wait...