Purkinje cell: Synaptic activation predicts voltage control of burst-pause (Masoli & D'Angelo 2017)

 Download zip file 
Help downloading and running models
Accession:239421
"The dendritic processing in cerebellar Purkinje cells (PCs), which integrate synaptic inputs coming from hundreds of thousands granule cells and molecular layer interneurons, is still unclear. Here we have tested a leading hypothesis maintaining that the significant PC output code is represented by burst-pause responses (BPRs), by simulating PC responses in a biophysically detailed model that allowed to systematically explore a broad range of input patterns. BPRs were generated by input bursts and were more prominent in Zebrin positive than Zebrin negative (Z+ and Z-) PCs. Different combinations of parallel fiber and molecular layer interneuron synapses explained type I, II and III responses observed in vivo. BPRs were generated intrinsically by Ca-dependent K channel activation in the somato-dendritic compartment and the pause was reinforced by molecular layer interneuron inhibition. BPRs faithfully reported the duration and intensity of synaptic inputs, such that synaptic conductance tuned the number of spikes and release probability tuned their regularity in the millisecond range. ..."
Reference:
1 . Masoli S, D'Angelo E (2017) Synaptic Activation of a Detailed Purkinje Cell Model Predicts Voltage-Dependent Control of Burst-Pause Responses in Active Dendrites. Front Cell Neurosci 11:278 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Synapse;
Brain Region(s)/Organism: Cerebellum;
Cell Type(s): Cerebellum Purkinje GABA cell;
Channel(s): I Potassium; I K,Ca;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Detailed Neuronal Models; Bursting;
Implementer(s): Masoli, Stefano [stefano.masoli at unipv.it];
Search NeuronDB for information about:  Cerebellum Purkinje GABA cell; I K,Ca; I Potassium;
4 1.64
20 5.59871
28 6.57217
35 7.90796
16 5.25035
18 5.41651
39 9.03825
23 5.91766
27 6.41559
40 9.35442
43 10.6659
37 8.42637
31 7.04471
33 7.42581
29 6.71071
12 4.95833
19 5.51376
41 9.77141
42 10.155
25 6.15293
36 8.13343
32 7.24613
38 8.69146
17 5.33913
46 12.5145
34 7.65725
47 13.2116
15 5.16573
22 5.79939
21 5.70571
24 6.02149
45 11.7814
30 6.8876
5 4.54221
26 6.29251
13 5.02047
9 4.76314
8 4.71002
44 11.242
6 4.58963
48 15.1114
7 4.64862
14 5.09819
11 4.88672
10 4.82935

Loading data, please wait...