Signaling pathways In D1R containing striatal spiny projection neurons (Blackwell et al 2018)

 Download zip file 
Help downloading and running models
Accession:239744
We implemented a mechanistic model of signaling pathways activated by dopamine D1 receptors, acetylcholine receptors, and glutamate. We use our novel, computationally efficient simulator, NeuroRD, to simulate stochastic interactions both within and between dendritic spines. Results show that the combined activity of several key plasticity molecules correctly predicts the occurrence of either LTP, LTD or no plasticity for numerous experimental protocols.
Reference:
1 . Blackwell KT, Salinas AG, Tewatia P, English B, Hellgren Kotaleski J, Lovinger DM (2019) Molecular mechanisms underlying striatal synaptic plasticity: relevance to chronic alcohol consumption and seeking. Eur J Neurosci 49:768-783 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Molecular Network; Synapse;
Brain Region(s)/Organism: Basal ganglia; Striatum;
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell;
Channel(s):
Gap Junctions:
Receptor(s): D1; mGluR5; M1; M4;
Gene(s):
Transmitter(s): Acetylcholine; Dopamine; Endocannabinoid; Glutamate;
Simulation Environment: NeuroRD;
Model Concept(s): G-protein coupled; Long-term Synaptic Plasticity; Signaling pathways; Alcohol Use Disorder;
Implementer(s): Blackwell, Avrama [avrama at gmu.edu];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; M1; M4; mGluR5; D1; Acetylcholine; Dopamine; Glutamate; Endocannabinoid;
/
D1signal_modelDB
robust
IC_SPNspine_AChigh.xml
IC_SPNspine_AClow.xml
IC_SPNspine_m1Rspine.xml
IC_SPNspine_Plc50.xml
IC_SPNspine_Plc75.xml
IC_SPNspineAChm4R_AC1_coupleGqhigh.xml
Model_2agdeg1dif1-stim20hz-blockM1.xml
Model_2agdeg1dif1-stim20hz-blockMGlu.xml
Model_2agdeg1dif1-stim20hz-noReb_lowDaDec3.xml
Model_2agdeg1dif1-stimtheta-blockM1.xml
Model_2agdeg1dif1-stimtheta-blockMGlu.xml
Model_2agdeg1dif1-stimtheta-noReb_DaDec1.xml *
Model_2agdeg1-stim20hz-blockM1.xml
Model_2agdeg1-stim20hz-blockMGlu.xml
Model_2agdeg1-stim20hz-noReb_lowDaDec3.xml
Model_2agdeg1-stimtheta-blockM1.xml
Model_2agdeg1-stimtheta-blockMGlu.xml
Model_2agdeg1-stimtheta-noReb_DaDec1.xml
Model_2agdeg4-stim20hz-blockM1.xml
Model_2agdeg4-stim20hz-blockMGlu.xml
Model_2agdeg4-stim20hz-noReb_lowDaDec3.xml
Model_2agdeg4-stimtheta-blockM1.xml
Model_2agdeg4-stimtheta-blockMGlu.xml
Model_2agdeg4-stimtheta-noReb_DaDec1.xml
Model_Da80_60and120and180_60rob.txt
Model_Da80-stim20hz-noReb_lowDaDec2.xml
Model_Da80-stim20hz-noReb_lowDaDec3.xml
Model_Da80-stimtheta-noReb_DaDec1.xml
Model_m1spine_60and120and180_60rob.txt
Model_m1spine2-stim20hz-blockM1.xml
Model_m1spine2-stim20hz-blockMGlu.xml
Model_m1spine2-stim20hz-noReb_lowDaDec3.xml
Model_m1spine2-stimtheta-blockM1.xml
Model_m1spine2-stimtheta-blockMGlu.xml
Model_m1spine2-stimtheta-noReb_DaDec1.xml
Model_m1spine3-stim20hz-blockM1.xml
Model_m1spine3-stim20hz-blockMGlu.xml
Model_m1spine3-stim20hz-noReb_lowDaDec3.xml
Model_m1spine3-stimtheta-blockM1.xml
Model_m1spine3-stimtheta-blockMGlu.xml
Model_m1spine3-stimtheta-noReb_DaDec1.xml
Model_m1spine-stim20hz-blockM1.xml
Model_m1spine-stim20hz-blockMGlu.xml
Model_m1spine-stim20hz-noReb_lowDaDec3.xml
Model_m1spine-stimtheta-blockM1.xml
Model_m1spine-stimtheta-blockMGlu.xml
Model_m1spine-stimtheta-noReb_DaDec1.xml
Model_robust_60and120and180_60.txt
Model_slow_diff-stim20hz-blockM1.xml
Model_slow_diff-stim20hz-blockMGlu.xml
Model_slow_diff-stim20hz-noReb_lowDaDec3.xml
Model_slow_diff-stimtheta-blockM1.xml
Model_slow_diff-stimtheta-blockMGlu.xml
Model_slow_diff-stimtheta-noReb_DaDec1.xml *
Model_slowCKp_60and120and180_60rob.txt
Model_slowCKp-stim20hz-noReb_lowDaDec3.xml
Model_slowCKp-stimtheta-noReb_DaDec1.xml
Model_SPNspine_AChigh_60and120and180_60rob.txt
Model_SPNspine_AChigh-bathCa.xml
Model_SPNspine_AChigh-bathDa.xml
Model_SPNspine_AChigh-bathDaCa.xml
Model_SPNspine_AChigh-blockCyA.xml
Model_SPNspine_AChigh-blockOA.xml
Model_SPNspine_AChigh-blockPap.xml
Model_SPNspine_AChigh-blockRoli.xml
Model_SPNspine_AChigh-stim20hz-noReb_lowDaDec3.xml
Model_SPNspine_AChigh-stimtheta-noReb_DaDec1.xml
Model_SPNspine_AClow_60and120and180_60rob.txt
Model_SPNspine_AClow-bathCa.xml
Model_SPNspine_AClow-bathDa.xml
Model_SPNspine_AClow-bathDaCa.xml
Model_SPNspine_AClow-blockCyA.xml
Model_SPNspine_AClow-blockOA.xml
Model_SPNspine_AClow-blockPap.xml
Model_SPNspine_AClow-blockRoli.xml
Model_SPNspine_AClow-stim20hz-noReb_lowDaDec3.xml
Model_SPNspine_AClow-stimtheta-noReb_DaDec1.xml
Model_SPNspine_Gislow_60and120and180_60rob.txt
Model_SPNspine_Gislow-bathCa.xml
Model_SPNspine_Gislow-bathDa.xml
Model_SPNspine_Gislow-bathDaCa.xml
Model_SPNspine_Gislow-blockCyA.xml
Model_SPNspine_Gislow-blockOA.xml
Model_SPNspine_Gislow-blockPap.xml
Model_SPNspine_Gislow-blockRoli.xml
Model_SPNspine_Gislow-stim20hz-noReb_lowDaDec3.xml
Model_SPNspine_Gislow-stimtheta-noReb_DaDec1.xml
Model_SPNspine_Gsfast_60and120and180_60rob.txt
Model_SPNspine_Gsfast-bathCa.xml
Model_SPNspine_Gsfast-bathDa.xml
Model_SPNspine_Gsfast-bathDaCa.xml
Model_SPNspine_Gsfast-blockCyA.xml
Model_SPNspine_Gsfast-blockOA.xml
Model_SPNspine_Gsfast-blockPap.xml
Model_SPNspine_Gsfast-blockRoli.xml
Model_SPNspine_Gsfast-stim20hz-noReb_lowDaDec3.xml
Model_SPNspine_Gsfast-stimtheta-noReb_DaDec1.xml
Model_SPNspine_Plc50_60and120and180_60plc50.txt
Model_SPNspine_Plc50-stim20hz-blockM1.xml
Model_SPNspine_Plc50-stim20hz-blockMGlu.xml
Model_SPNspine_Plc50-stim20hz-noReb_lowDaDec3.xml
Model_SPNspine_Plc50-stimtheta-blockM1.xml
Model_SPNspine_Plc50-stimtheta-blockMGlu.xml
Model_SPNspine_Plc50-stimtheta-noReb_DaDec1.xml
Model_SPNspine_Plc75_60and120and180_60plc75.txt
Model_SPNspine_Plc75-stim20hz-blockM1.xml
Model_SPNspine_Plc75-stim20hz-blockMGlu.xml
Model_SPNspine_Plc75-stim20hz-noReb_lowDaDec3.xml
Model_SPNspine_Plc75-stimtheta-blockM1.xml
Model_SPNspine_Plc75-stimtheta-blockMGlu.xml
Model_SPNspine_Plc75-stimtheta-noReb_DaDec1.xml
NeuroRDsims.bat
Rxn_SPNspine_2agdeg1.xml
Rxn_SPNspine_2agdeg1_dif1.xml
Rxn_SPNspine_2agdeg4.xml
Rxn_SPNspine_slow_diff-Glublock.xml
Rxn_SPNspine_slow_diffusion.xml
Rxn_SPNspine_slowDiff_slow2agDeg.xml
Rxn_SPNspine_slowDiff_slow2agDeg-Glublock.xml
Rxn_SPNspineAChm4R_Gshydr5_AC1_GiGsfast-GapD.xml
Rxn_SPNspineAChm4R_Gshydr5_AC1_Gislow-GapD.xml
Rxn_SPNspineAChm4R_Gshydr5_AC1_Gislow-GapD-CyA.xml
Rxn_SPNspineAChm4R_Gshydr5_AC1_Gsfast-GapD.xml
Rxn_SPNspineAChm4R_Gshydr5_AC1_Gsfast-GapD-CyA.xml
Stim_AChOA.xml
StimCouple20hz_Da80Dec2-10sITI.xml
StimCouple20hz_Da80Dec3-10sITI.xml
StimCouple20hz_Glu50_CaDend50_LowDaDec3-10sITI.xml
StimCouple20hz_Glu50_CaDend50_m1block-10sITI.xml
StimCouple20hz_Glu50_LowDaDec3-10sITI.xml
StimCouple20hz_Glu50_m1block-10sITI.xml
StimCouple20hz_m1block-10sITI.xml
StimCouple20hz_NoGlu_CaDend50_LowDaDec3-10sITI.xml
StimCouple20hz_NoGlu_LowDaDec3-10sITI.xml
StimCoupleTheta10hz_Da80Dec1-15sITI.xml
StimCoupleTheta10hz_Glu50_CaDend50_DaDec1-15sITI.xml
StimCoupleTheta10hz_Glu50_CaDend50_m1block-15sITI.xml
StimCoupleTheta10hz_Glu50_DaDec1-15sITI.xml
StimCoupleTheta10hz_Glu50_m1block-15sITI.xml
StimCoupleTheta10hz_m1block-15sITI.xml
StimCoupleTheta10hz_NoGlu_CaDend50_DaDec1-15sITI.xml
StimCoupleTheta10hz_NoGlu_DaDec1-15sITI.xml
StimDend_CaBath.xml
StimDend_DaBath.xml
StimDend_DaCaBath.xml
                            
filename trial 2ag_15c0 2ag_15c1 2ag_70c0 2ag_70c1 2ag_130c0 2ag_130c1 2ag_190c0 2ag_190c1 AphosNoPP_15c0 AphosNoPP_15c1 AphosNoPP_70c0 AphosNoPP_70c1 AphosNoPP_130c0 AphosNoPP_130c1 AphosNoPP_190c0 AphosNoPP_190c1 CKpCam_15c0 CKpCam_15c1 CKpCam_70c0 CKpCam_70c1 CKpCam_130c0 CKpCam_130c1 CKpCam_190c0 CKpCam_190c1 Epac1_15c0 Epac1_15c1 Epac1_70c0 Epac1_70c1 Epac1_130c0 Epac1_130c1 Epac1_190c0 Epac1_190c1 Pkc_15c0 Pkc_15c1 Pkc_70c0 Pkc_70c1 Pkc_130c0 Pkc_130c1 Pkc_190c0 Pkc_190c1 
Da80-stim20hz-noReb_lowDaDec2 0 61.45 57.03 144.93 147.08 146.34 142.31 126.84 122.23 789.64 712.18 1740.52 1563.18 2611.83 2362.18 2781.39 2691.59 0.0 0.0 16.17 17.39 45.88 52.98 83.96 79.74 21.25 23.78 83.12 84.52 134.07 134.89 126.98 130.33 8.41 0.0 44.23 97.81 55.04 210.67 80.78 241.06
Da80-stim20hz-noReb_lowDaDec2 1 42.45 41.68 141.82 140.6 135.36 131.36 110.18 107.45 818.42 848.74 1726.22 1798.62 2447.62 2438.73 2473.01 2336.27 0.0 0.0 17.32 15.34 40.69 42.19 69.22 66.53 20.78 23.78 84.75 87.84 97.67 99.31 108.58 110.77 8.04 6.9 41.62 115.97 43.32 224.1 65.08 195.16
Da80-stim20hz-noReb_lowDaDec2 2 57.37 58.82 145.66 143.25 122.84 124.88 124.25 123.6 843.89 802.71 1725.59 1483.82 2475.59 2263.3 2572.75 2470.44 0.0 0.0 22.37 25.7 47.94 51.95 70.28 78.93 18.29 20.71 86.93 88.01 123.86 123.0 129.76 124.24 7.81 0.0 43.77 131.31 51.51 211.27 71.86 259.94
Da80-stim20hz-noReb_lowDaDec3 0 53.44 51.4 134.52 135.45 134.84 127.99 97.31 96.88 829.98 757.7 1517.0 1402.76 1862.05 1701.02 2067.1 1903.03 0.0 0.0 25.0 27.66 59.79 66.49 83.79 94.53 26.13 21.74 62.45 62.78 79.97 79.7 75.45 73.56 5.29 0.0 46.77 143.72 48.34 236.29 61.04 259.43
Da80-stim20hz-noReb_lowDaDec3 1 48.67 52.68 146.51 149.68 148.22 144.87 128.04 127.73 751.5 641.09 1654.89 1614.96 2003.51 1762.0 1800.74 1773.68 0.0 0.0 13.97 16.03 32.9 40.36 49.65 56.0 30.45 34.78 74.38 73.56 80.16 76.89 65.82 65.98 10.39 0.0 43.05 146.23 48.81 146.32 64.74 189.62
Da80-stim20hz-noReb_lowDaDec3 2 55.9 49.61 132.04 132.59 132.07 131.4 117.11 117.33 755.59 587.39 1431.76 1262.24 1920.03 1793.29 1961.27 1913.39 0.0 0.0 21.63 21.91 44.02 49.01 71.75 72.62 23.0 19.43 58.15 59.2 77.8 75.65 74.02 70.88 3.94 0.0 34.54 103.23 40.53 244.21 65.78 231.6
Da80-stimtheta-noReb_DaDec1 0 57.6 64.95 126.41 126.45 92.83 94.74 38.98 38.57 780.88 629.07 1610.33 1468.01 2287.34 2074.84 2688.86 2737.28 0.0 0.0 94.64 97.17 161.98 195.58 210.76 226.31 28.93 29.66 71.65 72.88 124.63 125.05 102.08 105.06 9.25 28.9 75.92 249.46 129.42 343.6 71.46 162.98
Da80-stimtheta-noReb_DaDec1 1 67.2 64.19 148.35 144.78 85.59 88.74 32.78 33.8 818.7 559.01 1517.74 1366.32 2492.14 2437.75 3048.36 3147.5 0.0 0.0 95.98 101.39 198.28 220.43 249.34 258.28 13.39 11.51 69.6 70.79 137.14 141.97 110.85 110.05 10.35 0.0 75.15 168.73 132.46 374.89 76.9 162.72
Da80-stimtheta-noReb_DaDec1 2 61.8 62.91 133.35 133.53 86.36 85.5 31.33 33.88 779.6 904.49 1840.4 1622.0 2340.19 2221.58 3074.41 3095.29 0.0 0.0 87.41 99.13 196.35 202.28 253.48 247.37 24.23 29.92 91.86 94.19 110.55 114.09 114.62 108.85 6.96 0.0 68.62 220.26 151.64 440.61 85.41 243.36

Loading data, please wait...