External Tufted Cell Model (Ryan Viertel, Alla Borisyuk 2019)

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ODE model of the Mammalian External Tufted Cell
1 . Viertel R, Borisyuk A (2019) A Computational model of the mammalian external tufted cell. J Theor Biol 462:109-121 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Olfactory bulb main tufted cell external;
Channel(s): I Na,p; I h; I Na,t; I K; I Ca,p;
Gap Junctions:
Simulation Environment: MATLAB; C or C++ program; XPP;
Model Concept(s):
Search NeuronDB for information about:  I Na,p; I Na,t; I K; I h; I Ca,p;
# Model of the Mammalian ET cell

Computational model and files to recreate the results from the paper "A Computational Model of the Mammalian External Tufted Cell" https://doi.org/10.1016/j.jtbi.2018.10.003 

Author: Ryan Viertel

## Usage:

data = ET(input,sampling_rate);

input: input vector, if no input then just a vector of zeros

sampling_rate: rate at which the input vector should be sampled. 1000 for milisecond

returns the following struct:

data.T - time vector
data.X - ODE variables at each time step
* data.X(:,1) - Membrane Potential
* data.X(:,2) - nK
* data.X(:,3) - hNaP
* data.X(:,4) - hH
* data.X(:,5) - mLVA
* data.X(:,6) - hLVA
* data.X(:,7) - mBK
* data.X(:,8) - Calcium
* data.X(:,9) - nHVK

data.events - list of spike events

data.which - event type
* 1 - spike
* 2 - burst start
* 3 - burst end

data.current - system currents
* data.current(:,1) = transient sodium
* data.current(:,2) = fast potassium
* data.current(:,3) = leak
* data.current(:,4) = persistent sodium
* data.current(:,5) = hyperpolarization activated
* data.current(:,6) = LVA calcium
* data.current(:,7) = HVA calcium
* data.current(:,8) = large conductance potassium
* data.current(:,9) = HVK current

## example

### create the input vector
input = zeros(1,5000);
### run the model
data = ET(input,1000);
### plot the voltage trace

The code used to sample the model throughout parameter space to determine stability and investigate the effect of model parameters on model output is found in the ME-PCM directory

## xpp
The ODE file to recreate the bifurcation diagram is found in the xpp directory 

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