Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)

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Accession:243446
"Climbing fibers (CFs) provide instructive signals driving cerebellar learning, but mechanisms causing the variable CF responses in Purkinje cells (PCs) are not fully understood. Using a new experimentally validated PC model, we unveil the ionic mechanisms underlying CF-evoked distinct spike waveforms on different parts of the PC. We demonstrate that voltage can gate both the amplitude and the spatial range of CF-evoked Ca2+ influx by the availability of K+ currents. ... The voltage- and branch-specific CF responses can increase dendritic computational capacity and enable PCs to actively integrate CF signals."
Reference:
1 . Zang Y, Dieudonné S, De Schutter E (2018) Voltage- and Branch-Specific Climbing Fiber Responses in Purkinje Cells Cell Reports 24(6):1536-1549 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Cerebellum;
Cell Type(s): Cerebellum Purkinje GABA cell;
Channel(s): Ca pump; I K; I K,Ca; I Na,p; I h;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Active Dendrites; Synaptic Integration; Dendritic Action Potentials; Detailed Neuronal Models;
Implementer(s): Zang, Yunliang ;
Search NeuronDB for information about:  Cerebellum Purkinje GABA cell; I Na,p; I K; I h; I K,Ca; Ca pump; 
This model is from the following paper:

Yunliang Zang, Stéphane Dieudonné& Erik De Schutter. Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells. Cell Reports in press.

type the following commands on the terminal to implement the demo code, which generates both simple spikes and complex spikes (at 400 ms)

nrnivmodl mod
nrngui purkinje_demo.hoc

To get the dissociated PC model, add the following 
"dendA1_00 disconnect()
dendA1_01 disconnect()"
into purkinje_demo.hoc, which only preserves the dendritic trunk. 

To achieve voltage-regulated dendritic and somatic responses, change the values of stim1.amp in Purkinje_demo.hoc

The Na entry ratio is defined as the ratio of total Na+ influx (1 ms before and after spike peak) to the Na+ influx (1 ms before spike peak).

If you need to simulate some properties the present model can't do,please contact zangyl1983@gmail.com. I may know the answer.


Changelog
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cdp_*.mod files are updated due to issue mentioned in https://github.com/neuronsimulator/nrn/pull/1955.
CONSTANT block has no effect in the initialization of ion variables.

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