A biophysical model of vestibular ganglion neurons (Hight & Kalluri 2016, Ventura & Kalluri 2018)

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Accession:244202
A single compartment model in Matlab to represent vestibular ganglion neurons' somatic ion channels and their influence on firing patterns. Model is connected to a synthetic synaptic conductance to examine the relative influence of synaptic inputs and low-voltage gated potassium conductances on spike patterns.
References:
1 . Hight AE, Kalluri R (2016) A biophysical model examining the role of low-voltage-activated potassium currents in shaping the responses of vestibular ganglion neurons. J Neurophysiol 116:503-21 [PubMed]
2 . Rothman JS, Manis PB (2003) The roles potassium currents play in regulating the electrical activity of ventral cochlear nucleus neurons. J Neurophysiol 89:3097-113 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse;
Brain Region(s)/Organism:
Cell Type(s): Abstract integrate-and-fire leaky neuron; Abstract integrate-and-fire leaky neuron with dendritic subunits; Abstract single compartment conductance based cell; Vestibular neuron; Turtle vestibular neuron;
Channel(s): I Potassium; I Na,t; I Sodium; I A; I h; I_KLT; I_KHT;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: MATLAB;
Model Concept(s): Simplified Models; Activity Patterns;
Implementer(s): Hight, Ariel E. ; Kalluri, Radha [radha at usc.edu]; Ventura, Christopher M. ;
Search NeuronDB for information about:  I Na,t; I A; I h; I Sodium; I Potassium; I_KHT; I_KLT; Glutamate; 
This is the readme.txt file for the models associated with the 
papers shown below:

1. A paper submitted in 2018

2. Hight AE, Kalluri R. A biophysical model examining the role of low-voltage-activated 
potassium currents in shaping the responses of vestibular ganglion neurons. 
J Neurophysiol. 2016 Aug 01; 116(2):503-21.

To run the simulation type Single_Compartment_Annotated at the Matlab command line.

To control the simulation parameters, open and edit the Single_Compartment_Annotated file.

Analysis scripts for Ventura & Kalluri (2018, submitted) can be found in the Analysis_Ventura & Kalluri subfolder.

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