ModelDB is moving. Check out our new site at https://modeldb.science. The corresponding page is https://modeldb.science/244412.

STDP and BDNF in CA1 spines (Solinas et al. 2019)

 Download zip file 
Help downloading and running models
Accession:244412
Storing memory traces in the brain is essential for learning and memory formation. Memory traces are created by joint electrical activity in neurons that are interconnected by synapses and allow transferring electrical activity from a sending (presynaptic) to a receiving (postsynaptic) neuron. During learning, neurons that are co-active can tune synapses to become more effective. This process is called synaptic plasticity or long-term potentiation (LTP). Timing-dependent LTP (t-LTP) is a physiologically relevant type of synaptic plasticity that results from repeated sequential firing of action potentials (APs) in pre- and postsynaptic neurons. T-LTP is observed during learning in vivo and is a cellular correlate of memory formation. T-LTP can be elicited by different rhythms of synaptic activity that recruit distinct synaptic growth processes underlying t-LTP. The protein brain-derived neurotrophic factor (BDNF) is released at synapses and mediates synaptic growth in response to specific rhythms of t-LTP stimulation, while other rhythms mediate BDNF-independent t-LTP. Here, we developed a realistic computational model that accounts for our previously published experimental results of BDNF-independent 1:1 t-LTP (pairing of 1 presynaptic with 1 postsynaptic AP) and BDNF-dependent 1:4 t-LTP (pairing of 1 presynaptic with 4 postsynaptic APs). The model explains the magnitude and time course of both t-LTP forms and allows predicting t-LTP properties that result from altered BDNF turnover. Since BDNF levels are decreased in demented patients, understanding the function of BDNF in memory processes is of utmost importance to counteract Alzheimer’s disease.
Reference:
1 . Solinas SMG, Edelmann E, Leßmann V, Migliore M (2019) A kinetic model for Brain-Derived Neurotrophic Factor mediated spike timing-dependent LTP. PLoS Comput Biol 15:e1006975 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Synapse; Dendrite;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Na,t; I_KD; I K; I h; I A; I Calcium;
Gap Junctions:
Receptor(s): AMPA; NMDA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Facilitation; Long-term Synaptic Plasticity; Short-term Synaptic Plasticity; STDP;
Implementer(s): Solinas, Sergio [solinas at unipv.it]; Migliore, Michele [Michele.Migliore at Yale.edu];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; AMPA; NMDA; I Na,t; I A; I K; I h; I Calcium; I_KD; Glutamate;
import json as js
from neuron import h

def get_cell_list():
    sl = h.SectionList()
    sl.allroots()
    return sl

def get_section_list(cell):
    print(("Selected section where to start for h.wholetree() %s"%cell.name()))

    # Access parent section
    cell.push()
    # Populate sectionlist
    sl = h.SectionList()
    sl.wholetree()
    h.pop_section()
    return sl

def geom_nseg(sl, check = False):
    if check:
        for sec in sl:
            print((sec.nseg))
    for sec in sl:
        sec.nseg = int((sec.L/(0.1*h.lambda_f(100))+.9)/2)*2 + 1
    if check:
        for sec in sl:
            print((sec.nseg))

def dump_structure_in_dict_for_hoc(sl ,filename,sec_list,mec_list):
    sec_dict = {}
    for sec_n in sec_list:
        sec = sec_dict[sec_n]
        # get geometry
        
    #         sec_mechs = npy.get_variables(h,sec)

    #         # Saving initial vm
    #         fn.write('v_init = '+str(round(sec.v,2))+'\n')
    #         # Saving passive properties
    #         for sm_name,sm in sec_mechs.iteritems():
    #             if 'diam' == sm_name or 'L' == sm_name or 'Ra' == sm_name:
    #                 fn.write(sm_name+' = '+str(round(sm,4))+'\n')
    #         fn.write('\n')
    #         # Saving single channel paramenters
    #         for sm_name in mec_list:
    #             if sm_name in sec_mechs.keys():
    #                 sm = sec_mechs[sm_name]
    #                 if 'GRC' in sm_name:
    #                     mech_params = npy.get_variables_from_mechanism(h,sm,1)
    #                     fn.write(sm_name+'\n')
    #                     for p_n,p in mech_params.iteritems():
    #                         fn.write(p_n+' = '+str(p)+'\n')
    #                     fn.write('\n')
    #         fn.write('\n')
            
    # fn.close()

Loading data, please wait...