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Voltage and light-sensitive Channelrhodopsin-2 model (ChR2-H134R) (Williams et al. 2013) (NEURON)
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" ... Focusing on one of the most widely used ChR2 mutants (H134R) with enhanced current, we collected a comprehensive experimental data set of the response of this ion channel to different irradiances and voltages, and used these data to develop a model of ChR2 with empirically-derived voltage- and irradiance- dependence, where parameters were fine-tuned via simulated annealing optimization. This ChR2 model offers: 1) accurate inward rectification in the current-voltage response across irradiances; 2) empirically-derived voltage- and light-dependent kinetics (activation, deactivation and recovery from inactivation); and 3) accurate amplitude and morphology of the response across voltage and irradiance settings. Temperature-scaling factors (Q10) were derived and model kinetics was adjusted to physiological temperatures. ... "
Williams JC, Xu J, Lu Z, Klimas A, Chen X, Ambrosi CM, Cohen IS, Entcheva E (2013) Computational optogenetics: empirically-derived voltage- and light-sensitive channelrhodopsin-2 model.
PLoS Comput Biol
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Ion Channel Kinetics;
Giugliano, Michele [mgiugliano at gmail.com];
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