Cerebellum Purkinje cell: dendritic ion channels activated by climbing fibre (Ait Ouares et al 2019)

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"In cerebellar Purkinje neuron (PN) dendrites, the transient depolarisation associated with a climbing fibre (CF) EPSP activates voltage-gated Ca2+ channels (VGCCs), voltage-gated K+ channels (VGKCs) and Ca2+ activated SK and BK K+ channels. The resulting membrane potential (Vm) and Ca2+ transients play a fundamental role in dendritic integration and synaptic plasticity of parallel fibre inputs. Here we report a detailed investigation of the kinetics of dendritic Ca2+ and K+ channels activated by CF-EPSPs, based on optical measurements of Vm and Ca2+ transients and on a single-compartment NEURON model reproducing experimental data. ... "
1 . Ait Ouares K, Filipis L, Tzilivaki A, Poirazi P, Canepari M (2019) Two Distinct Sets of Ca2+ and K+ Channels Are Activated at Different Membrane Potentials by the Climbing Fiber Synaptic Potential in Purkinje Neuron Dendrites. J Neurosci 39:1969-1981 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Dendrite;
Brain Region(s)/Organism: Cerebellum;
Cell Type(s): Cerebellum Purkinje GABA cell;
Channel(s): I Calcium; I K,Ca; I Potassium;
Gap Junctions:
Simulation Environment: NEURON;
Model Concept(s): Simplified Models; Calcium dynamics; Active Dendrites;
Implementer(s): Filipis, Luiza [luizafilipu at gmail.com];
Search NeuronDB for information about:  Cerebellum Purkinje GABA cell; I K,Ca; I Calcium; I Potassium;
: synaptic current of climbing fiber

The model of the current associated with a CF-EPSP, designed to mimic the shape of the current
reported by Llano et al., 1991.
The parameters  were tuned to obtain the match of experimental V m and Ca 2+ transients.

Current Model Reference: Karima Ait Ouares , Luiza Filipis , Alexandra Tzilivaki , Panayiota Poirazi , Marco Canepari (2018) Two distinct sets of Ca 2+ and K + channels 
are activated at different membrane potential by the climbing fibre synaptic potential in Purkinje neuron dendrites. 

PubMed link: 

Contact: Filipis Luiza (luiza.filipis@univ-grenoble-alpes.fr)
    SUFFIX climbing
    RANGE del,tauO,tauC, icin, delf,tauOf,tauCf,fastfact
    RANGE i, e, ef, g

    g = 15e-3 (siemens/cm2)  < 0, 1e9 >
    e = 0    (millivolt)
    del = 1 (ms)
    tauO = 0.4 (ms)
    tauC = 14 (ms)  
        delf = 1 (ms)
    tauOf = 0.4 (ms)
    tauCf = 14 (ms)
    icin=0   (nanoamp/cm2)
    ef = 0    (millivolt)

    (mV) = (millivolt)
    (mA) = (milliamp)
    (nA) = (nanoamp)
    (pA) = (picoamp)
    (S)  = (siemens)
    i   (nanoamp/cm2)
    v   (millivolt) 


    if (t < del) {
          i = icin
    } else {
          i =icin+(1-fastfact)*g*(1-exp(-(t-del)/tauO))*exp(-(t-del)/tauC)*(e)+fastfact*g*(1-exp(-(t-delf)/tauOf))*exp(-(t-delf)/tauCf)*(ef)

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