Hippocampal CA1 pyramidal cell demonstrating dynamic mode switching (Berteau & Bullock 2020)

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A simulated proposed single-cell mechanism for CA1’s behavior as an associative mismatch detector. Shifts in spiking mode (accomplished via KCNQ interaction with chloride leak currents) signal matches vs. mismatches.
1 . Berteau S, Bullock D (2020) Simulations reveal how M-currents and memory-based inputs from CA3 enable single neuron mismatch detection for EC3 inputs to the CA1 subfield of hippocampus Journal of Neurophysiology, accepted
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Predictive Coding Network;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s):
Channel(s): I M; I Cl, leak; I Na, slow inactivation;
Gap Junctions:
Receptor(s): Gaba; Glutamate; Cholinergic Receptors;
Transmitter(s): Glutamate; Gaba; Acetylcholine;
Simulation Environment: Python;
Model Concept(s): Activity Patterns; Coincidence Detection; Rate-coding model neurons; Bursting;
Implementer(s): Berteau, Stefan [berteau at bu.edu];
Search NeuronDB for information about:  Glutamate; Gaba; Cholinergic Receptors; I M; I Cl, leak; I Na, slow inactivation; Acetylcholine; Gaba; Glutamate;
Final Submission to Senselab
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