//genesis
/*************************** MS Model, Version 9.1 *********************
**************************** CaL12channel.g *********************
Rebekah Evans updated 3/20/12
******************************************************************************
******************************************************************************/
function create_CaL12
str chanName = "CaL12_channel"
str compPath = "/library"
int c
float Ek = 0.140 //(nernst calculated for 35degrees, [Cain] 50nM [Caout]2mM)
//Ek is overwritten the the GHK object if it is used.
float xmin = -0.1
float xmax = 0.05
int xdivs = 3000
float mPower = 1.0 //mh is an equally common form to m2h (tuckwell 2012)
float hPower = 1.0
if (calciuminact == 1)
float zpower = 1.0
else
float zpower = 0
end
float increment ={{xmax}-{xmin}}/{xdivs}
echo "CaL12 increment:" {increment} "V"
float x = -0.1
float surf = 0
float gMax = 0
float hTauCaL12 = 44.3e-3
float mTauCaL12 = 0.0
float mvHalfCaL12 = -8.9e-3
float mkCaL12 = -6.7e-3
float hvHalfCaL12 = -55e-3
float hkCaL12 = 8e-3
float hInfCaL12 = 0.0
float mInfCaL12 = 0.0
float theta = 0.0
float beta = 0.0
float beta_exp = 0.0
float mA = 0.0
float mB = 0.0
float qFactCaL12 = {qfactCa}
pushe {compPath}
create tabchannel {chanName}
setfield {chanName} Ek {Ek} Xpower {mPower} Ypower {hPower} Zpower {zpower}
call {chanName} TABCREATE X {xdivs} {xmin} {xmax}
call {chanName} TABCREATE Y {xdivs} {xmin} {xmax}
//fill in the voltage act and inact tables
for(c = 0; c < {xdivs} + 1; c = c + 1)
/************************ Begin CaL12_mTau *********************/
//mA = 0.0398e6*(vMemb + 8.124e-3)./(exp((vMemb + 8.124e-3)/9.005e-3) - 1);
//mB = 0.99e3*exp(vMemb/31.4e-3);
//mTauCaL12 = 1./(mA + mB) / qFactCaL12;
theta = 0.0398e6*{ {x} + 8.124e-3}
beta = {{x} + 8.124e-3}/9.005e-3
beta_exp = {{exp {beta}} - 1.0}
mA = {{theta}/{beta_exp}}
beta = {{x}/31.4e-3}
beta_exp = {exp {beta}}
mB = 0.99e3*{beta_exp}
mTauCaL12 = {1/{mA + mB}}/{qFactCaL12}
setfield {chanName} X_A->table[{c}] {mTauCaL12}
/************************ End CaL12_mTau ***********************/
/************************ Begin CaL12_mInf *********************/
// mInfCaL12 = 1./(1 + exp((vMemb - mvHalfCaL12)/mkCaL12));
beta = {{x} - {mvHalfCaL12}}/{mkCaL12}
beta_exp = {exp {beta}} + 1.0
mInfCaL12 = 1.0/{beta_exp}
setfield {chanName} X_B->table[{c}] {mInfCaL12}
/************************ End CaL12_mInf ***********************/
/************************ Begin CaL12_hTau *********************/
// hTauCaL12
setfield {chanName} Y_A->table[{c}] {{hTauCaL12}/{qFactCaL12}}
/************************ End CaL12_hTau ***********************/
/************************ Begin CaL12_hInf *********************/
// hInfCaL12 = 1./(1 + exp((vMemb - hvHalfCaL12)/hkCaL12));
beta = {{x} - {hvHalfCaL12}}/{hkCaL12}
beta_exp = {exp {beta}} + 1.0
//0.17 has vdep inactivation, 0.83 does not inactivate
hInfCaL12 = {0.17*{1.0/{beta_exp}} + 0.83}
setfield {chanName} Y_B->table[{c}] {hInfCaL12}
/************************ End CaL12_hInf ***********************/
x = x + increment
end
tweaktau {chanName} X
tweaktau {chanName} Y
//fill in the Z table with CDI values
if (calciuminact == 1)
addCDI {chanName}
end
addGHK {chanName}
setfield {chanName} Gbar {gMax*surf}
pope
end
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