Striatal Spiny Projection Neuron, inhibition enhances spatial specificity (Dorman et al 2018)

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Accession:245411
We use a computational model of a striatal spiny projection neuron to investigate dendritic spine calcium dynamics in response to spatiotemporal patterns of synaptic inputs. We show that spine calcium elevation is stimulus-specific, with supralinear calcium elevation in cooperatively stimulated spines. Intermediate calcium elevation occurs in neighboring non-stimulated dendritic spines, predicting heterosynaptic effects. Inhibitory synaptic inputs enhance the difference between peak calcium in stimulated spines, and peak calcium in non-stimulated spines, thereby enhancing stimulus specificity.
Reference:
1 . Dorman DB, Jedrzejewska-Szmek J, Blackwell KT (2018) Inhibition enhances spatially-specific calcium encoding of synaptic input patterns in a biologically constrained model. Elife, Kennedy, Mary B, ed. [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Basal ganglia;
Cell Type(s): Neostriatum spiny neuron;
Channel(s): Ca pump; Kir; I A; I A, slow; I CAN; I K,Ca; I Krp; I Na,t; I L high threshold; I R; I T low threshold; IK Bkca; IK Skca; Na/Ca exchanger;
Gap Junctions:
Receptor(s): AMPA; NMDA; GabaA;
Gene(s): Cav3.2 CACNA1H; Cav3.3 CACNA1I; Cav1.2 CACNA1C; Cav1.3 CACNA1D; Cav2.2 CACNA1B; Kv4.2 KCND2; Kir2.1 KCNJ2; Kv2.1 KCNB1;
Transmitter(s): Gaba; Glutamate;
Simulation Environment: GENESIS;
Model Concept(s): Calcium dynamics; Detailed Neuronal Models; Synaptic Integration; Synaptic Plasticity;
Implementer(s): Dorman, Daniel B ;
Search NeuronDB for information about:  GabaA; AMPA; NMDA; I Na,t; I L high threshold; I T low threshold; I A; I K,Ca; I CAN; I A, slow; Na/Ca exchanger; I Krp; I R; Ca pump; Kir; IK Bkca; IK Skca; Gaba; Glutamate;
//genesis

/***************************		MS Model, Version 9.1	*********************
**************************** 	  		CaN.g 			*********************
Rebekah Evans updated 3/20/12
******************************************************************************
******************************************************************************/

function create_CaN
	str chanName = "CaN_channel"
	str compPath = "/library"

	int c	
	float Ek = 0.140 //(nernst calculated for 35degrees, [Cain] 50nM [Caout]2mM)
			//Ek is overwritten the the GHK object if it is used. 
	float x = -0.1
	int xdivs = 3000
	float xmin = -0.1
	float xmax = 0.05
        float increment ={{xmax}-{xmin}}/{xdivs}
        echo "CaN increment:" {increment} "V"
  	float mPower = 2.0  // Kasai 1992 p169
  	float hPower = 1.0
	if (calciuminact == 1)
		float zpower = 1.0
	else
		float zpower = 0
	end	

	float mvHalfCaN = -3e-3
	float mkCaN = -8e-3
	float hvHalfCaN = -74.8e-3
	float hkCaN = 6.5e-3
	float mTauCaN = 0.0
	float mInfCaN = 0.0
	float hTauCaN = 70e-3
	float hInfCaN = 0.0

	float theta	= 0.0
	float theta_1 = 0.0
	float beta	= 0.0
	float beta_exp	= 0.0
	float mA	= 0.0
	float mB	= 0.0
	float surf = 0.0
 	float gMax = 0
	float qFactCaN = {qfactCa}

	pushe {compPath}

	create tabchannel {chanName}
  	setfield {chanName} Ek {Ek} Xpower {mPower} Ypower {hPower} Zpower {zpower}
	call {chanName} TABCREATE X {xdivs} {xmin} {xmax}
        call {chanName} TABCREATE Y {xdivs} {xmin} {xmax}

	for(c = 0; c < {xdivs}; c = c + 1)
		/************************ Begin CaN_mTau *********************/
		// mA = 39800*(vMemb + 17.19e-3)./
		//                      (exp((vMemb + 17.19e-3)/15.22e-3)-1);
		// mB = 384.2*exp(vMemb/23.82e-3);
		// mTauCaN = (1./(mA + mB)) / qFactCaN;
		// parameters tuned to fit Kasai 1992


		theta = 39800*{ {x} + 17.19e-3}
		beta = {{x}  + 17.19e-3}/15.22e-3
		beta_exp = {exp {beta}}
		beta_exp = beta_exp - 1.0
		mA = {{theta}/{beta_exp}}

		beta = {{x}/23.82e-3}
		beta_exp = {exp {beta}} 
		mB = 384.2*{beta_exp}

		mTauCaN = {{1.0/{mA + mB}}/{qFactCaN}}		
		setfield {chanName} X_A->table[{c}] {mTauCaN}
		/************************ End CaN_mTau ***********************/
	
		/************************ Begin CaN_mInf *********************/
		// mInfCaN   = 1./(1 + exp((vMemb - mvHalfCaN)/mkCaN));
		// parameters tuned so m2 fits Bargas and Surmeier 1994 boltzmann curve
		beta = {{x} - {mvHalfCaN}}/{mkCaN}
		beta_exp = {exp {beta}} + 1.0
		mInfCaN = 1.0/{beta_exp}
		setfield {chanName} X_B->table[{c}] {mInfCaN}
		/************************ End CaN_mInf ***********************/

		/************************ Begin CaN_hTau *********************/ 
		// hTauCaN  Mcnaughton et al., 1997 table 2 tau 1 for calcium
		setfield {chanName} Y_A->table[{c}] {{hTauCaN}/{qFactCaN}}
		/************************ End CaN_hTau ***********************/

		/************************ Begin CaN_hInf *********************/
		// hInfCaN   = 1./(1 + exp((vMemb - hvHalfCaN)/hkCaN));
		// Mcnaughton et al., 1997 table 2
		beta = {{x} - {hvHalfCaN}}/{hkCaN}
		beta_exp = {exp {beta}} + 1
                //0.21 has vdep inactivation, 0.79 does not inactivate
                hInfCaN = 0.21 * {1/{beta_exp}} + 0.79
 		setfield {chanName} Y_B->table[{c}] {hInfCaN}
		/************************ End CaN_hInf ***********************/
	
   	x = x + increment
	end

	tweaktau {chanName} X
	tweaktau {chanName} Y

	//fill in the Z table with CDI values
	if (calciuminact == 1)
        addCDI {chanName}
	end

    addGHK {chanName}
  	setfield {chanName} Gbar {gMax*surf}

  	pope
end


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