Striatal Spiny Projection Neuron, inhibition enhances spatial specificity (Dorman et al 2018)

 Download zip file 
Help downloading and running models
We use a computational model of a striatal spiny projection neuron to investigate dendritic spine calcium dynamics in response to spatiotemporal patterns of synaptic inputs. We show that spine calcium elevation is stimulus-specific, with supralinear calcium elevation in cooperatively stimulated spines. Intermediate calcium elevation occurs in neighboring non-stimulated dendritic spines, predicting heterosynaptic effects. Inhibitory synaptic inputs enhance the difference between peak calcium in stimulated spines, and peak calcium in non-stimulated spines, thereby enhancing stimulus specificity.
1 . Dorman DB, Jedrzejewska-Szmek J, Blackwell KT (2018) Inhibition enhances spatially-specific calcium encoding of synaptic input patterns in a biologically constrained model. Elife, Kennedy, Mary B, ed. [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Basal ganglia;
Cell Type(s): Neostriatum spiny neuron;
Channel(s): Ca pump; Kir; I A; I A, slow; I CAN; I K,Ca; I Krp; I Na,t; I L high threshold; I R; I T low threshold; IK Bkca; IK Skca; Na/Ca exchanger;
Gap Junctions:
Receptor(s): AMPA; NMDA; GabaA;
Gene(s): Cav3.2 CACNA1H; Cav3.3 CACNA1I; Cav1.2 CACNA1C; Cav1.3 CACNA1D; Cav2.2 CACNA1B; Kv4.2 KCND2; Kir2.1 KCNJ2; Kv2.1 KCNB1;
Transmitter(s): Gaba; Glutamate;
Simulation Environment: GENESIS;
Model Concept(s): Calcium dynamics; Detailed Neuronal Models; Synaptic Integration; Synaptic Plasticity;
Implementer(s): Dorman, Daniel B ;
Search NeuronDB for information about:  GabaA; AMPA; NMDA; I Na,t; I L high threshold; I T low threshold; I A; I K,Ca; I CAN; I A, slow; Na/Ca exchanger; I Krp; I R; Ca pump; Kir; IK Bkca; IK Skca; Gaba; Glutamate;

/* This script should be modified to create the channels for which the
   activations and taus will be plotted

/* First create the channels.  This example is taken from the traub91
  channels in neurokit/prototypes
int calciuminact=1
float qfactCa=2
include ../globals.g
include defaults.g   // Some definitions used by traub91chan.g
include CDI-GHK.g
include tabchanforms.g
include CaL12CDI.g // the functions to create the channels
include CaL13CDI.g
include CaNCDI.g
include CaRCDI.g
include CaT32.g
include CaT33.g
include KaS.g
include KaF.g
include Kir.g
include Krp.g
include NaF.g
include BK.g
include SK.g
include KaS_old.g
include NMDA_CDIGate.g
// a place to put channels - usually created in defaults.g or protodefs.g
if (!({exists /library}))
    create neutral /library
pushe /library
  make_NMDA_CDI_gate /library/NMDA_CDI_gate

/* This defines the default channel that will be plotted */
str channelpath = "/library/KAs_channel"

include chanplot.g  // modified from neurokit/xchannel_funcs.g
do_xchannel_funcs    // defined in chanplot.g 

ce /
xshow /channel_params  // show the form with graphs and widgets

Loading data, please wait...