Striatal Spiny Projection Neuron, inhibition enhances spatial specificity (Dorman et al 2018)

 Download zip file 
Help downloading and running models
Accession:245411
We use a computational model of a striatal spiny projection neuron to investigate dendritic spine calcium dynamics in response to spatiotemporal patterns of synaptic inputs. We show that spine calcium elevation is stimulus-specific, with supralinear calcium elevation in cooperatively stimulated spines. Intermediate calcium elevation occurs in neighboring non-stimulated dendritic spines, predicting heterosynaptic effects. Inhibitory synaptic inputs enhance the difference between peak calcium in stimulated spines, and peak calcium in non-stimulated spines, thereby enhancing stimulus specificity.
Reference:
1 . Dorman DB, Jedrzejewska-Szmek J, Blackwell KT (2018) Inhibition enhances spatially-specific calcium encoding of synaptic input patterns in a biologically constrained model. Elife, Kennedy, Mary B, ed. [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Basal ganglia;
Cell Type(s): Neostriatum spiny neuron;
Channel(s): Ca pump; Kir; I A; I A, slow; I CAN; I K,Ca; I Krp; I Na,t; I L high threshold; I R; I T low threshold; IK Bkca; IK Skca; Na/Ca exchanger;
Gap Junctions:
Receptor(s): AMPA; NMDA; GabaA;
Gene(s): Cav3.2 CACNA1H; Cav3.3 CACNA1I; Cav1.2 CACNA1C; Cav1.3 CACNA1D; Cav2.2 CACNA1B; Kv4.2 KCND2; Kir2.1 KCNJ2; Kv2.1 KCNB1;
Transmitter(s): Gaba; Glutamate;
Simulation Environment: GENESIS;
Model Concept(s): Calcium dynamics; Detailed Neuronal Models; Synaptic Integration; Synaptic Plasticity;
Implementer(s): Dorman, Daniel B ;
Search NeuronDB for information about:  GabaA; AMPA; NMDA; I Na,t; I L high threshold; I T low threshold; I A; I K,Ca; I CAN; I A, slow; Na/Ca exchanger; I Krp; I R; Ca pump; Kir; IK Bkca; IK Skca; Gaba; Glutamate;
/
modelDB_eLife2018
.git
hooks
applypatch-msg.sample *
commit-msg.sample *
post-update.sample *
pre-applypatch.sample *
pre-commit.sample *
prepare-commit-msg.sample *
pre-push.sample *
pre-rebase.sample *
pre-receive.sample *
update.sample *
                            
#!/bin/sh
#
# An example hook script to verify what is about to be committed.
# Called by "git commit" with no arguments.  The hook should
# exit with non-zero status after issuing an appropriate message if
# it wants to stop the commit.
#
# To enable this hook, rename this file to "pre-commit".

if git rev-parse --verify HEAD >/dev/null 2>&1
then
	against=HEAD
else
	# Initial commit: diff against an empty tree object
	against=4b825dc642cb6eb9a060e54bf8d69288fbee4904
fi

# If you want to allow non-ASCII filenames set this variable to true.
allownonascii=$(git config --bool hooks.allownonascii)

# Redirect output to stderr.
exec 1>&2

# Cross platform projects tend to avoid non-ASCII filenames; prevent
# them from being added to the repository. We exploit the fact that the
# printable range starts at the space character and ends with tilde.
if [ "$allownonascii" != "true" ] &&
	# Note that the use of brackets around a tr range is ok here, (it's
	# even required, for portability to Solaris 10's /usr/bin/tr), since
	# the square bracket bytes happen to fall in the designated range.
	test $(git diff --cached --name-only --diff-filter=A -z $against |
	  LC_ALL=C tr -d '[ -~]\0' | wc -c) != 0
then
	cat <<\EOF
Error: Attempt to add a non-ASCII file name.

This can cause problems if you want to work with people on other platforms.

To be portable it is advisable to rename the file.

If you know what you are doing you can disable this check using:

  git config hooks.allownonascii true
EOF
	exit 1
fi

# If there are whitespace errors, print the offending file names and fail.
exec git diff-index --check --cached $against --

Loading data, please wait...