Striatal Spiny Projection Neuron, inhibition enhances spatial specificity (Dorman et al 2018)

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We use a computational model of a striatal spiny projection neuron to investigate dendritic spine calcium dynamics in response to spatiotemporal patterns of synaptic inputs. We show that spine calcium elevation is stimulus-specific, with supralinear calcium elevation in cooperatively stimulated spines. Intermediate calcium elevation occurs in neighboring non-stimulated dendritic spines, predicting heterosynaptic effects. Inhibitory synaptic inputs enhance the difference between peak calcium in stimulated spines, and peak calcium in non-stimulated spines, thereby enhancing stimulus specificity.
1 . Dorman DB, Jedrzejewska-Szmek J, Blackwell KT (2018) Inhibition enhances spatially-specific calcium encoding of synaptic input patterns in a biologically constrained model. Elife, Kennedy, Mary B, ed. [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Basal ganglia;
Cell Type(s): Neostriatum spiny neuron;
Channel(s): Ca pump; Kir; I A; I A, slow; I CAN; I K,Ca; I Krp; I Na,t; I L high threshold; I R; I T low threshold; IK Bkca; IK Skca; Na/Ca exchanger;
Gap Junctions:
Receptor(s): AMPA; NMDA; GabaA;
Gene(s): Cav3.2 CACNA1H; Cav3.3 CACNA1I; Cav1.2 CACNA1C; Cav1.3 CACNA1D; Cav2.2 CACNA1B; Kv4.2 KCND2; Kir2.1 KCNJ2; Kv2.1 KCNB1;
Transmitter(s): Gaba; Glutamate;
Simulation Environment: GENESIS;
Model Concept(s): Calcium dynamics; Detailed Neuronal Models; Synaptic Integration; Synaptic Plasticity;
Implementer(s): Dorman, Daniel B ;
Search NeuronDB for information about:  GabaA; AMPA; NMDA; I Na,t; I L high threshold; I T low threshold; I A; I K,Ca; I CAN; I A, slow; Na/Ca exchanger; I Krp; I R; Ca pump; Kir; IK Bkca; IK Skca; Gaba; Glutamate;

//this is a function to create a file will all the important parameters for each simulation
//things like Mg concentration, CDI parameters, Fura parameters, NMDA parameters etc.

function Store_Parameters
	print "calciumdye=" {calciumdye}
	print "calciumtype=" {calciumtype}
	print "calciuminact=" {calciuminact}
	print "NMDAbuffermode=" {NMDAbuffermode}
	if (calciumdye == 1)
		print "Furaconc=" {btotal3} 
		print "FuraKf=" {Kf3}
		print "FuraKb=" {Kb3}
	elif (calciumdye == 2)
		print "Fluo5Fconc=" {btotal5}
		print "Fluo5FKf=" {Kf5}
		print "Fluo5FKb=" {Kb5}
    elif (calciumdye == 3)
		print "Fluo4conc=" {btotal6}
		print "Fluo4Kf=" {Kf6}
		print "Fluo4Kb=" {Kb6}
	print "AMPAdes=" {AMPAdes}
	print "AMPAdestau=" {AMPAdestau}
	print "NMDAdes=" {NMDAdes}
	print "NMDAdestau=" {NMDAdestau}
	print "NMDAfracCa=" {NMDAperCa}
	print "nmdaKMg=" {KMg}
	print "nmdaGamma=" {gamma}
	print "Mgconc=" {CMg}


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