Striatal Spiny Projection Neuron, inhibition enhances spatial specificity (Dorman et al 2018)

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We use a computational model of a striatal spiny projection neuron to investigate dendritic spine calcium dynamics in response to spatiotemporal patterns of synaptic inputs. We show that spine calcium elevation is stimulus-specific, with supralinear calcium elevation in cooperatively stimulated spines. Intermediate calcium elevation occurs in neighboring non-stimulated dendritic spines, predicting heterosynaptic effects. Inhibitory synaptic inputs enhance the difference between peak calcium in stimulated spines, and peak calcium in non-stimulated spines, thereby enhancing stimulus specificity.
1 . Dorman DB, Jedrzejewska-Szmek J, Blackwell KT (2018) Inhibition enhances spatially-specific calcium encoding of synaptic input patterns in a biologically constrained model. Elife, Kennedy, Mary B, ed. [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Basal ganglia;
Cell Type(s): Neostriatum spiny neuron;
Channel(s): Ca pump; Kir; I A; I A, slow; I CAN; I K,Ca; I Krp; I Na,t; I L high threshold; I R; I T low threshold; IK Bkca; IK Skca; Na/Ca exchanger;
Gap Junctions:
Receptor(s): AMPA; NMDA; GabaA;
Gene(s): Cav3.2 CACNA1H; Cav3.3 CACNA1I; Cav1.2 CACNA1C; Cav1.3 CACNA1D; Cav2.2 CACNA1B; Kv4.2 KCND2; Kir2.1 KCNJ2; Kv2.1 KCNB1;
Transmitter(s): Gaba; Glutamate;
Simulation Environment: GENESIS;
Model Concept(s): Calcium dynamics; Detailed Neuronal Models; Synaptic Integration; Synaptic Plasticity;
Implementer(s): Dorman, Daniel B ;
Search NeuronDB for information about:  GabaA; AMPA; NMDA; I Na,t; I L high threshold; I T low threshold; I A; I K,Ca; I CAN; I A, slow; Na/Ca exchanger; I Krp; I R; Ca pump; Kir; IK Bkca; IK Skca; Gaba; Glutamate;

/***************************		MS Model, Version 9.1	*********************
**************************** 	  		connectCaChannels.g		*********************


function coupleCaPoolCaChannel(bufferName, compPath, caChannelName)

  str bufferName
  str compPath
  str caChannelName

  pushe {compPath}

  if({isa difshell {compPath}/{bufferName}})
    addmsg {caChannelName}GHK {bufferName} INFLUX Ik 
    addmsg {bufferName} {caChannelName}GHK CIN C
    if (calciuminact == 1)
        addmsg {bufferName} {caChannelName} CONCEN C
  elif({isa Ca_concen {compPath}/{bufferName}})
    addmsg {caChannelName}GHK {bufferName} I_Ca Ik 
    addmsg {bufferName} {caChannelName}GHK CIN Ca 
    if (calciuminact == 1)
        addmsg {bufferName} {caChannelName} CONCEN Ca
    echo "coupleCaPoolCaChannel: Whoops" {compPath}/{bufferName} "not found"

  pope {compPath}


function addCaChannel(channelName, compPath, caBufferName)

  str channelName, compPath
  str caBufferName

  pushe {compPath}

    // Copy the GHK part of the channel from library
    copy /library/{channelName}GHK {channelName}GHK

    coupleCaPoolCaChannel {caBufferName} {compPath} {channelName}

    // Couple channel, its GHK object and compartment together
    addmsg {compPath} {channelName}GHK VOLTAGE Vm
    addmsg {channelName}GHK {compPath} CHANNEL Gk Ek
    addmsg {channelName} {channelName}GHK PERMEABILITY Gk



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