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Hippocampal Mossy Fiber bouton: presynaptic KV7 channel function (Martinello et al 2019)
Download zip file
Help downloading and running models
Model Information
Model File
Citations
Accession:
245417
Reference:
1 .
Martinello K, Giacalone E, Migliore M, Brown DA, Shah MM (2019) The subthreshold-active KV7 current regulates neurotransmission by limiting spike-induced Ca2+ influx in hippocampal mossy fiber synaptic terminals.
Commun Biol
2
:145
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Synapse;
Brain Region(s)/Organism:
Hippocampus;
Cell Type(s):
Channel(s):
I A;
I CAN;
I K,leak;
I M;
I Na,t;
I K;
Gap Junctions:
Receptor(s):
AMPA;
Gene(s):
Transmitter(s):
Glutamate;
Simulation Environment:
NEURON;
Model Concept(s):
Action Potentials;
Implementer(s):
Migliore, Michele [Michele.Migliore at Yale.edu];
Giacalone, Elisabetta [elisabetta.giacalone at pa.ibf.cnr.it];
Search NeuronDB
for information about:
AMPA
;
I Na,t
;
I A
;
I K
;
I K,leak
;
I M
;
I CAN
;
Glutamate
;
Download the displayed file
/
modeldb_Kv7_MFB
README.html
cacumm.mod
*
Other models using cacumm.mod:
Channel density variability among CA1 neurons (Migliore et al. 2018)
Circadian rhythmicity shapes astrocyte morphology and neuronal function in CA1 (McCauley et al 2020)
can2t.mod
kaprox.mod
*
Other models using kaprox.mod:
CA1 pyramidal neuron (Migliore et al 1999)
CA1 pyramidal neuron synaptic integration (Li and Ascoli 2006, 2008)
CA1 pyramidal neuron: action potential backpropagation (Gasparini & Migliore 2015)
CA1 pyramidal neuron: calculation of MRI signals (Cassara et al. 2008)
CA1 pyramidal neuron: conditional boosting of dendritic APs (Watanabe et al 2002)
CA1 pyramidal neuron: dendritic spike initiation (Gasparini et al 2004)
CA1 pyramidal neuron: effects of Ih on distal inputs (Migliore et al 2004)
CA1 pyramidal neuron: effects of Lamotrigine on dendritic excitability (Poolos et al 2002)
CA1 pyramidal neuron: effects of R213Q and R312W Kv7.2 mutations (Miceli et al. 2013)
CA1 pyramidal neuron: functional significance of axonal Kv7 channels (Shah et al. 2008)
CA1 pyramidal neuron: integration of subthreshold inputs from PP and SC (Migliore 2003)
CA1 pyramidal neuron: rebound spiking (Ascoli et al.2010)
CA1 pyramidal neuron: schizophrenic behavior (Migliore et al. 2011)
CA1 pyramidal neuron: signal propagation in oblique dendrites (Migliore et al 2005)
CA1 pyramidal neurons: binding properties and the magical number 7 (Migliore et al. 2008)
CA1 pyramidal neurons: effect of external electric field from power lines (Cavarretta et al. 2014)
CA1 pyramidal neurons: effects of Alzheimer (Culmone and Migliore 2012)
CA1 pyramidal neurons: effects of Kv7 (M-) channels on synaptic integration (Shah et al. 2011)
CA1 pyramidal neurons: effects of a Kv7.2 mutation (Miceli et al. 2009)
Ca1 pyramidal neuron: reduction model (Marasco et al. 2012)
Calcium waves and mGluR-dependent synaptic plasticity in CA1 pyr. neurons (Ashhad & Narayanan 2013)
Channel density variability among CA1 neurons (Migliore et al. 2018)
Circadian rhythmicity shapes astrocyte morphology and neuronal function in CA1 (McCauley et al 2020)
Computational neuropharmacology of CA1 pyramidal neuron (Ferrante et al. 2008)
Early-onset epileptic encephalopathy (Miceli et al. 2015)
Effect of the initial synaptic state on the probability to induce LTP and LTD (Migliore et al. 2015)
Effects of electric fields on cognitive functions (Migliore et al 2016)
Estimation and Production of Time Intervals (Migliore et al 2001)
Excitability of PFC Basal Dendrites (Acker and Antic 2009)
Feedforward inhibition in pyramidal cells (Ferrante & Ascoli 2015)
Functional impact of dendritic branch point morphology (Ferrante et al., 2013)
Model of CA1 activity during working memory task (Spera et al. 2016)
Modulation of hippocampal rhythms by electric fields and network topology (Berzhanskaya et al. 2013)
Neural Query System NQS Data-Mining From Within the NEURON Simulator (Lytton 2006)
Neuronal morphology goes digital ... (Parekh & Ascoli 2013)
Neurophysiological impact of inactivation pathways in A-type K+ channels (Fineberg et al 2012)
STDP and BDNF in CA1 spines (Solinas et al. 2019)
Small world networks of Type I and Type II Excitable Neurons (Bogaard et al. 2009)
Spine head calcium in a CA1 pyramidal cell model (Graham et al. 2014)
Sympathetic Preganglionic Neurone (Briant et al. 2014)
kdrca1.mod
*
Other models using kdrca1.mod:
CA1 pyramidal neuron (Migliore et al 1999)
CA1 pyramidal neuron synaptic integration (Li and Ascoli 2006, 2008)
CA1 pyramidal neuron: action potential backpropagation (Gasparini & Migliore 2015)
CA1 pyramidal neuron: calculation of MRI signals (Cassara et al. 2008)
CA1 pyramidal neuron: conditional boosting of dendritic APs (Watanabe et al 2002)
CA1 pyramidal neuron: effects of Ih on distal inputs (Migliore et al 2004)
CA1 pyramidal neuron: effects of Lamotrigine on dendritic excitability (Poolos et al 2002)
CA1 pyramidal neuron: effects of R213Q and R312W Kv7.2 mutations (Miceli et al. 2013)
CA1 pyramidal neuron: functional significance of axonal Kv7 channels (Shah et al. 2008)
CA1 pyramidal neuron: integration of subthreshold inputs from PP and SC (Migliore 2003)
CA1 pyramidal neuron: rebound spiking (Ascoli et al.2010)
CA1 pyramidal neuron: schizophrenic behavior (Migliore et al. 2011)
CA1 pyramidal neuron: signal propagation in oblique dendrites (Migliore et al 2005)
CA1 pyramidal neurons: binding properties and the magical number 7 (Migliore et al. 2008)
CA1 pyramidal neurons: effect of external electric field from power lines (Cavarretta et al. 2014)
CA1 pyramidal neurons: effects of Alzheimer (Culmone and Migliore 2012)
CA1 pyramidal neurons: effects of Kv7 (M-) channels on synaptic integration (Shah et al. 2011)
CA1 pyramidal neurons: effects of a Kv7.2 mutation (Miceli et al. 2009)
Ca1 pyramidal neuron: reduction model (Marasco et al. 2012)
Channel density variability among CA1 neurons (Migliore et al. 2018)
Circadian rhythmicity shapes astrocyte morphology and neuronal function in CA1 (McCauley et al 2020)
Computational neuropharmacology of CA1 pyramidal neuron (Ferrante et al. 2008)
Early-onset epileptic encephalopathy (Miceli et al. 2015)
Effect of the initial synaptic state on the probability to induce LTP and LTD (Migliore et al. 2015)
Effects of electric fields on cognitive functions (Migliore et al 2016)
Estimation and Production of Time Intervals (Migliore et al 2001)
Feedforward inhibition in pyramidal cells (Ferrante & Ascoli 2015)
Functional impact of dendritic branch point morphology (Ferrante et al., 2013)
Model of CA1 activity during working memory task (Spera et al. 2016)
Modulation of hippocampal rhythms by electric fields and network topology (Berzhanskaya et al. 2013)
Neuronal morphology goes digital ... (Parekh & Ascoli 2013)
Neurophysiological impact of inactivation pathways in A-type K+ channels (Fineberg et al 2012)
STDP and BDNF in CA1 spines (Solinas et al. 2019)
Small world networks of Type I and Type II Excitable Neurons (Bogaard et al. 2009)
Spine head calcium in a CA1 pyramidal cell model (Graham et al. 2014)
Vomeronasal sensory neuron (Shimazaki et al 2006)
kir.mod
kmb.mod
*
Other models using kmb.mod:
Channel density variability among CA1 neurons (Migliore et al. 2018)
Circadian rhythmicity shapes astrocyte morphology and neuronal function in CA1 (McCauley et al 2020)
naxn_J.mod
fig4_modeldb.hoc
fig4_modeldb.ses
mosinit.hoc
screenshot1.png
screenshot2.png
load_file("nrngui.hoc") xopen("fig4_modeldb.hoc")
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