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Gamma genesis in the basolateral amygdala (Feng et al 2019)
 
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Accession:
247968
Using in vitro and in vivo data we develop the first large-scale biophysically and anatomically realistic model of the basolateral amygdala nucleus (BL), which reproduces the dynamics of the in vivo local field potential (LFP). Significantly, it predicts that BL intrinsically generates the transient gamma oscillations observed in vivo. The model permitted exploration of the poorly understood synaptic mechanisms underlying gamma genesis in BL, and the model's ability to compute LFPs at arbitrary numbers of recording sites provided insights into the characteristics of the spatial properties of gamma bursts. Furthermore, we show how gamma synchronizes principal cells to overcome their low firing rates while simultaneously promoting competition, potentially impacting their afferent selectivity and efferent drive, and thus emotional behavior.
Reference:
1 .
Feng F, Headley DB , Amir A, Kanta V, Chen Z, Pare D, Nair S (2019) Gamma oscillations in the basolateral amygdala: biophysical mechanisms and computational consequences
eNeuro
Model Information
(Click on a link to find other models with that property)
Model Type:
Realistic Network;
Extracellular;
Synapse;
Dendrite;
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Amygdala;
Cell Type(s):
Hodgkin-Huxley neuron;
Channel(s):
I Na,t;
I L high threshold;
I A;
I M;
I Sodium;
I Calcium;
I Potassium;
I_AHP;
Ca pump;
I h;
I Na,p;
I K;
Gap Junctions:
Gap junctions;
Receptor(s):
AMPA;
NMDA;
Gaba;
Dopaminergic Receptor;
Gene(s):
Transmitter(s):
Dopamine;
Norephinephrine;
Simulation Environment:
NEURON;
Model Concept(s):
Oscillations;
Gamma oscillations;
Short-term Synaptic Plasticity;
Implementer(s):
Feng, Feng [ffvxb at mail.missouri.edu];
Search NeuronDB
for information about:
AMPA
;
NMDA
;
Gaba
;
Dopaminergic Receptor
;
I Na,p
;
I Na,t
;
I L high threshold
;
I A
;
I K
;
I M
;
I h
;
I Sodium
;
I Calcium
;
I Potassium
;
I_AHP
;
Ca pump
;
Dopamine
;
Norephinephrine
;
/
FengEtAl2019
input
readme.txt
bg2pyr.mod
ca.mod
*
Other models using ca.mod:
A 1000 cell network model for Lateral Amygdala (Kim et al. 2013)
Distinct current modules shape cellular dynamics in model neurons (Alturki et al 2016)
STDP depends on dendritic synapse location (Letzkus et al. 2006)
cadyn.mod
*
Other models using cadyn.mod:
Distinct current modules shape cellular dynamics in model neurons (Alturki et al 2016)
cal2.mod
*
Other models using cal2.mod:
A 1000 cell network model for Lateral Amygdala (Kim et al. 2013)
CA3 Pyramidal Neuron (Migliore et al 1995)
Coincident glutamatergic depolarization effects on Cl- dynamics (Lombardi et al, 2021)
Distinct current modules shape cellular dynamics in model neurons (Alturki et al 2016)
Impact of dendritic atrophy on intrinsic and synaptic excitability (Narayanan & Chattarji, 2010)
Sympathetic Preganglionic Neurone (Briant et al. 2014)
capool.mod
function_TMonitor.mod
*
Other models using function_TMonitor.mod:
A 1000 cell network model for Lateral Amygdala (Kim et al. 2013)
Distinct current modules shape cellular dynamics in model neurons (Alturki et al 2016)
gap.mod
*
Other models using gap.mod:
Gamma oscillations in hippocampal interneuron networks (Bartos et al 2002)
Gfluct_new_exc.mod
Gfluct_new_inh.mod
h.mod
*
Other models using h.mod:
Distinct current modules shape cellular dynamics in model neurons (Alturki et al 2016)
halfgap.mod
im.mod
*
Other models using im.mod:
Distinct current modules shape cellular dynamics in model neurons (Alturki et al 2016)
interD2interD_STFD_new.mod
interD2pyrD_STFD_new.mod
kadist.mod
kaprox.mod
*
Other models using kaprox.mod:
Distinct current modules shape cellular dynamics in model neurons (Alturki et al 2016)
kdrca1.mod
*
Other models using kdrca1.mod:
Distinct current modules shape cellular dynamics in model neurons (Alturki et al 2016)
kdrca1DA.mod
*
Other models using kdrca1DA.mod:
Distinct current modules shape cellular dynamics in model neurons (Alturki et al 2016)
kdrinter.mod
*
Other models using kdrinter.mod:
A 1000 cell network model for Lateral Amygdala (Kim et al. 2013)
Distinct current modules shape cellular dynamics in model neurons (Alturki et al 2016)
leak.mod
*
Other models using leak.mod:
A 1000 cell network model for Lateral Amygdala (Kim et al. 2013)
Distinct current modules shape cellular dynamics in model neurons (Alturki et al 2016)
Distinct current modules shape cellular dynamics in model neurons (Alturki et al 2016)
leakDA.mod
*
Other models using leakDA.mod:
A 1000 cell network model for Lateral Amygdala (Kim et al. 2013)
Distinct current modules shape cellular dynamics in model neurons (Alturki et al 2016)
leakinter.mod
*
Other models using leakinter.mod:
A 1000 cell network model for Lateral Amygdala (Kim et al. 2013)
Distinct current modules shape cellular dynamics in model neurons (Alturki et al 2016)
na3.mod
*
Other models using na3.mod:
Distinct current modules shape cellular dynamics in model neurons (Alturki et al 2016)
na3DA.mod
*
Other models using na3DA.mod:
Distinct current modules shape cellular dynamics in model neurons (Alturki et al 2016)
nainter.mod
*
Other models using nainter.mod:
A 1000 cell network model for Lateral Amygdala (Kim et al. 2013)
Distinct current modules shape cellular dynamics in model neurons (Alturki et al 2016)
nap.mod
*
Other models using nap.mod:
Distinct current modules shape cellular dynamics in model neurons (Alturki et al 2016)
nat.mod
*
Other models using nat.mod:
Distinct current modules shape cellular dynamics in model neurons (Alturki et al 2016)
pyrD2interD_STFD.mod
pyrD2pyrD_STFD_new.mod
sahp.mod
*
Other models using sahp.mod:
Distinct current modules shape cellular dynamics in model neurons (Alturki et al 2016)
sahpNE.mod
*
Other models using sahpNE.mod:
Distinct current modules shape cellular dynamics in model neurons (Alturki et al 2016)
vecevent.mod
xtra.mod
xtra_imemrec.mod
BL_main.hoc
BLcells_template_LFP_segconsider_all_Iinject_recordingimembrane.hoc
function_calcconduc.hoc
function_ConnectInputs_invivo_op.hoc
function_ConnectInternal_gj_simplify.hoc
function_ConnectInternal_simplify_online_op.hoc
function_ConnectTwoCells.hoc
function_LoadMatrix.hoc
function_NetStimOR.hoc
*
Other models using function_NetStimOR.hoc:
A 1000 cell network model for Lateral Amygdala (Kim et al. 2013)
function_TimeMonitor.hoc
*
Other models using function_TimeMonitor.hoc:
A 1000 cell network model for Lateral Amygdala (Kim et al. 2013)
interneuron_template_gj_LFP_Iinject_recordingimembrane.hoc
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