Factors contribution to GDP-induced [Cl-]i transients (Lombardi et al 2019)

 Download zip file 
Help downloading and running models
Accession:253369
This models are used to evaluate which factors influence the GDP (giant depolarizing potential) induced [Cl-]I transients based on a initial model of P. Jedlicka
Reference:
1 . Lombardi A, Jedlicka P, Luhmann HJ, Kilb W (2019) Interactions Between Membrane Resistance, GABA-A Receptor Properties, Bicarbonate Dynamics and Cl-Transport Shape Activity-Dependent Changes of Intracellular Cl- Concentration Int J of Mol Sci [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Dendrite; Synapse;
Brain Region(s)/Organism: Mouse; Hippocampus;
Cell Type(s): Hippocampus CA3 pyramidal GLU cell;
Channel(s):
Gap Junctions:
Receptor(s): GabaA;
Gene(s):
Transmitter(s): Gaba;
Simulation Environment: NEURON;
Model Concept(s): Synaptic Plasticity;
Implementer(s):
Search NeuronDB for information about:  Hippocampus CA3 pyramidal GLU cell; GabaA; Gaba;
/
LombardiEtAl2019
Isolated_Dendrite_tauNKCC1__Fig9
cldif_CA3_NKCC1_HCO3.mod *
gabaA_Cl_HCO3.mod *
VDpas.mod *
vecevent.mod *
cell_isolated_dendrite.hoc *
cell_soma_dendrite.hoc *
cell_soma_dendrite_1000um.hoc
cell_soma_dendrite_fine.hoc
Freq_PSC.ses
gabaA_Cl_HCO3.o
GABA-Stim_1xPSC_isolated_dendrite_GUI.hoc
GABA-Stim_2xPSC_Spatial_Sum_isolated_dendrite.hoc
GABA-Stim_2xPSC_Spatial_Sum_isolated_dendrite_enlarged_tauNKCC1.hoc
GABA-Stim_3xPSC_isolated_dendrite_GUI.hoc
GABA-Stim_5xPSC_Freq_isolated_dendrite.hoc
GABA-Stim_5xPSC_Freq_isolated_dendrite_back.hoc
GABA-Stim_5xPSC_Freq_isolated_dendrite_enlarged_tauNKCC1.hoc
GABA-Stim_5xPSC_Spatial_isolated_dendrite-Draft.hoc
init_Cldif_isolated_dendrite.hoc
Isolated_Dendrite.ses *
Isolated_Dendrite_Diff_Flux_1xGABA.ses
Isolated_Dendrite_Diff_Flux_3xGABA.ses
Isolated_Dendrite_Diff_Flux_Laptop.ses
start_GABA-Stim_2xPSC_Spatial_Sum_isolated_dendrite.hoc
start_GABA-Stim_2xPSC_Spatial_Sum_isolated_dendrite_enlarged_tauNKCC1.hoc
start_GABA-Stim_5xPSC_Freq_isolated_dendrite.hoc
start_GABA-Stim_5xPSC_Freq_isolated_dendrite_enlarged_tauNKCC1.hoc
start_procedure.hoc
                            
:  Vector stream of events

NEURON {
	THREADSAFE
	ARTIFICIAL_CELL VecStim
	POINTER ptr
}

ASSIGNED {
	index
	etime (ms)
	ptr
}


INITIAL {
	index = 0
	element()
	if (index > 0) {
		net_send(etime - t, 1)
	}
}

NET_RECEIVE (w) {
	if (flag == 1) {
		net_event(t)
		element()
		if (index > 0) {
			net_send(etime - t, 1)
		}
	}
}

DESTRUCTOR {
VERBATIM
	void* vv = (void*)(_p_ptr);
        if (vv) {
		hoc_obj_unref(*vector_pobj(vv));
	}
ENDVERBATIM
}

PROCEDURE element() {
VERBATIM
  { void* vv; int i, size; double* px;
	i = (int)index;
	if (i >= 0) {
		vv = (void*)(_p_ptr);
		if (vv) {
			size = vector_capacity(vv);
			px = vector_vec(vv);
			if (i < size) {
				etime = px[i];
				index += 1.;
			}else{
				index = -1.;
			}
		}else{
			index = -1.;
		}
	}
  }
ENDVERBATIM
}

PROCEDURE play() {
VERBATIM
	void** pv;
	void* ptmp = NULL;
	if (ifarg(1)) {
		ptmp = vector_arg(1);
		hoc_obj_ref(*vector_pobj(ptmp));
	}
	pv = (void**)(&_p_ptr);
	if (*pv) {
		hoc_obj_unref(*vector_pobj(*pv));
	}
	*pv = ptmp;
ENDVERBATIM
}

Loading data, please wait...