Voltage imaging calibration in tuft dendrites of mitral cells (Djurisic et al 2004)

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Accession:253991
A detailed morphology of a tuft is provided in a reconstruction of a mitral cell that was used to place simulated estimates on for the calibration of EPSPs as recorded in voltage imaging in the real cells (estimated to be within +12% to -18% of the actual amplitude).
Reference:
1 . Djurisic M, Antic S, Chen WR, Zecevic D (2004) Voltage imaging from dendrites of mitral cells: EPSP attenuation and spike trigger zones. J Neurosci 24:6703-14 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Olfactory bulb;
Cell Type(s): Olfactory bulb main mitral GLU cell;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:
Model Concept(s): Methods;
Implementer(s):
Search NeuronDB for information about:  Olfactory bulb main mitral GLU cell;
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DjurisicEtAl2004
readme.html
EPSPClamp.mod *
avgdiams1.txt *
avgdiams2.txt *
avgdiams3.txt *
avgdiams4.txt *
avgdiams5.txt *
basediams1.txt *
basediams2.txt *
basediams3.txt *
basediams4.txt *
basediams5.txt *
epsp.txt *
epsp_soma.txt *
lengths1.txt *
lengths2.txt *
lengths3.txt *
lengths4.txt *
lengths5.txt *
membrane.hoc
morphology.hoc
mosinit.hoc
nltemplate.hoc
order1.txt *
order2.txt *
order3.txt *
order4.txt *
order5.txt *
parameters.hoc *
screenshot1.png
screenshot2.png
test.ses
xyangles1.txt *
xyangles2.txt *
xyangles3.txt *
xyangles4.txt *
xyangles5.txt *
xyz1.txt *
xyz2.txt *
xyz3.txt *
xyz4.txt *
xyz5.txt *
zangles1.txt *
zangles2.txt *
zangles3.txt *
zangles4.txt *
zangles5.txt *
                            
load_file("nrngui.hoc")
load_file("mulfit.hoc")
load_file("parameters.hoc")
load_file("morphology.hoc")
load_file("membrane.hoc")
celsius = 36

double epsp[271]
double epsp_soma[271]
objref epspf
epspf = new File()
epspf.ropen("epsp.txt")
i=0
while (!epspf.eof()) {
    epsp[i]=epspf.scanvar()
    i=i+1
}
epspf.close()

epspf.ropen("epsp_soma.txt")
i=0
while (!epspf.eof()) {
    epsp_soma[i]=epspf.scanvar()
    i=i+1
}
epspf.close()

proc init() {
    finitialize(Erest)
    fcurrent()
    V_soma=soma_sc.v(1)
    V_primden_beg=tuft_nl.sect[0].v(1)
    V_experiment=epsp[0]
    V_experiment_soma=epsp_soma[0]
}

init()

proc advance() {
    fadvance()
    V_soma=soma_sc.v(1)
    V_primden_beg=tuft_nl.sect[0].v(1)
    if (int(2*t)>270) {
        V_experiment=0
    } else {
        V_experiment=epsp[int(2*t)]
    }
    if (int(2*t)>270) {
        V_experiment_soma=0
    } else {
        V_experiment_soma=epsp_soma[int(2*t)]
    }
}


load_file("test.ses")
{doNotify()}
run()

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