A computational model of oxytocin modulation of olfactory recognition memory (Linster & Kelsch 2019)

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Accession:257940
Model of olfactory bulb (OB) and anterior olfactory nucleus (AON) pyramidal cells. Includes olfactory sensory neurons, mitral cells, periglomerular, external tufted and granule interneurons and pyramidal cells. Can be built to include a feedback loop between OB and AON. Output consists of voltage and spikes over time in all neurons. Model can be stimulated with simulated odorants. The code submitted here has served for a number of modeling explorations of olfactory bulb and cortex. The model architecture is defined in "bulb.dat" with synapses defined in "channels.dat". The main function to run the model can be found in "neuron.c". Model architecture is constructed in "set.c" from types defined in "sim.c". A make file to create an executable is located in "neuron.mak".
Reference:
1 . Linster C, Kelsch W (2019) A computational model of oxytocin modulation of olfactory recognition memory. eNeuro [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Olfactory bulb;
Cell Type(s): Olfactory bulb main mitral GLU cell; Olfactory bulb main interneuron periglomerular GABA cell; Olfactory bulb main interneuron granule MC GABA cell; Olfactory bulb main interneuron granule TC GABA cell; Olfactory bulb main tufted cell external;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: C or C++ program;
Model Concept(s):
Implementer(s): Linster, Christiane [cl243 at cornell.edu];
Search NeuronDB for information about:  Olfactory bulb main mitral GLU cell; Olfactory bulb main interneuron periglomerular GABA cell; Olfactory bulb main interneuron granule MC GABA cell; Olfactory bulb main interneuron granule TC GABA cell;
#include "cell.init"
                                                          
/** this file contains personal organization and menue routines **/
/** new routines for menue choices may be included **/





void MENU ()
{
int	      	step_number, x_ext, y_ext, x_mul, y_mul, y_mul2, end, delta, n;  
FILE	      	*read_from; 
FILE		*raster_file; 
char 	      	dummy[10], to[50], name[50];
 int            oo[100];
int 	      	h, test, testi, testo, tot, o, s, nods;  
enum BOOLEAN  	flag, glob, cc, ia;                                   
int	      	points, count, t1, t2, t0;  
int	      	yc, yp, ys, crossx, cor, index, unit, index1, index2;
int 		toto, i, m, from, too;
float		mul, c, value;
EVENT maus;

	
	cc = FAUX;
	N_UNITS = 0; 	   
	N_LINKS = 0;
	GET_RUN_PARAMETERS ("para.dat");
        INIT_GRAPHICS ();
	main_window = OPEN_WINDOW (0, 0, WIDTH, HEIGHT, blanc);  
      	maus = GET_EVENT (); 
	count = 0;
/***/first_loop:/***/
	GET_RUN_PARAMETERS ("para.dat");

	printf (" 1. set up new 2. load config 3. exit\n");
	scanf ("%d", &test);   

	if ((test != 1) && (test != 2) && (test != 3) && (test != 4))
		{
		printf (" wrong choice, try again\n");
		goto first_loop;
		}
      	if (test == 3)    
		{
		DESTROY_WINDOW (main_window);
		return;        
		}
	if (test == 2)
		{ 
		  GET_RUN_PARAMETERS ("para.dat");
		  GET_CHANNELS (); 
		/*READ_CONFIG ();*/ 
		if ((MOL != 0) && (REC != 0))
		  MAKE_REC_SENS ();
		goto last_loop;
		} /** if (test == 2 **/
	if (test == 1)
		{

/***/set_up_loop:/***/   
		GET_RUN_PARAMETERS ("para.dat");
		TEST_SETUP ();	
		printf (" Nunits %d Nlinks %d \n", N_UNITS, N_LINKS) ;
		
		goto last_loop;
        	} /** if (test == 1 **/




/***/run_loop:/***/  

	printf (" in run loop \n");
	RUN ();
	/*STEP_COUNT ();*/
	AVS ();
	GET_AVERAGES (0, N_STEPS-1);
	POTS ();
	SAVE_POTS("test11");
	/*HEBB_AON_PC (RATE);*/

/***/draw_loop:/***/
	SHOW ();  
/***/last_loop:/***/
	printf (" 1. draw again  31. odor stim 32. electrical 21. same input 3. save pyrs 4. set up new 5.save mits 6. save grans 7. save averages  8. correlations 9. show weights 10. save_weigts 11. save time avs 13. exit\n"); 

	scanf ("%d", &test);
	if ((test != 1) && (test != 21) && (test != 4) && (test != 5) && (test != 6) && (test != 7) && (test != 3) && (test != 8) && (test != 13) && (test != 2) && (test != 31) && (test != 32) && (test !=13) && (test != 9) && (test != 10) && (test != 11) && (test != 12))
		{
		printf (" wrong choice, try again\n");
		goto last_loop;
		} 

	if (test == 13)  
		{                         
		FREE_ALL ();
		goto first_loop;
		}
	if (test ==12)
		{
		NULL_ODORS ();
		TESTSN ();
		goto run_loop;
		}
	if (test == 31)
		{
		NULL_ODORS ();
		/*printf ("number of mols? .. conc ?\n");
		scanf ("%d %f", &nods, &c);
		for (o=0; o < nods; o++)
		  {oo[o] = floor (RANF ()*GLOM);printf ("o %d \n", oo[o]);}
		for (o=0; o < nods; o++)
		       for (s=0; s < N_STEPS; s++)
			 molecules[oo[o]].stim[s] = c;
		*/
		RESP (1.0, 25, 75);
		/*CONTEXT_AON ();
		printf ("gust from .. too .. \n");
		scanf ("%d %d", &from, &too);
		for (s = 0; s<N_STEPS; s++)
			GUST[s] = 0.0;
		for (s=from; s<too;s++)
			GUST[s] = 1.0;*/
		goto run_loop;
		}
	if (test == 32)
		{
		STIMULATE ();
		goto run_loop;
		}

	if (test == 21)
		goto run_loop;           

	if (test == 4)
		{
		 goto set_up_loop; 
		}

	if (test == 5)
		{                     
		SAVE_MITRAL_SPIKES ();  
		goto last_loop;
		}   
	if (test == 6)
		{
		SAVE_GRANULE_SPIKES ();
		goto last_loop;
		}
	if (test == 3)
		{
		SAVE_PYR_SPIKES ();
		goto last_loop;
		}
	if (test == 7)
		{
		GET_AVERAGES ();
		SAVE_AVERAGES ();
		goto last_loop;
		}	
	if (test == 11)
		{
		SAVE_SUMS ();
		goto last_loop;
		}		
	if (test == 8)
		{

		CROSS (AVSM, AVSM, N_STEPS, 1, 100);
		CROSS (AVSG, AVSG, N_STEPS, 1, 100);
		CROSS (AVSP, AVSP, N_STEPS, 1, 100);
		CROSS (AVSM, AVSP, N_STEPS, 1, 100);
		CROSS (AVSM, AVSG, N_STEPS, 1, 100);
		CROSS (AVSG, AVSP, N_STEPS, 1, 100); 
		goto last_loop;
		}
	if (test == 9)
		{
		SHOW_WEIGHTS ();
		goto last_loop;
		}
	if (test == 10)
		{
		SAVE_WEIGHTS ();
		goto last_loop;
		}
	if (test == 1)
		{     
		goto draw_loop;
		} 

   
}




void main ()
{                
int test, goon;
	/*printf (" here we go\n");  
	printf ("alea \n");
	scanf ("%lf", &alea);*/
	alea = .89;
	ialea =  alea * 2147483647;  
loppo:	

    MENU ();       
	printf (" 1. ciao 2. hii \n");
	scanf ("%d", &goon);
	if (goon == 2)
		goto loppo;
	printf (" ciao \n"); 
} 




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