A computational model of oxytocin modulation of olfactory recognition memory (Linster & Kelsch 2019)

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Accession:257940
Model of olfactory bulb (OB) and anterior olfactory nucleus (AON) pyramidal cells. Includes olfactory sensory neurons, mitral cells, periglomerular, external tufted and granule interneurons and pyramidal cells. Can be built to include a feedback loop between OB and AON. Output consists of voltage and spikes over time in all neurons. Model can be stimulated with simulated odorants. The code submitted here has served for a number of modeling explorations of olfactory bulb and cortex. The model architecture is defined in "bulb.dat" with synapses defined in "channels.dat". The main function to run the model can be found in "neuron.c". Model architecture is constructed in "set.c" from types defined in "sim.c". A make file to create an executable is located in "neuron.mak".
Reference:
1 . Linster C, Kelsch W (2019) A computational model of oxytocin modulation of olfactory recognition memory. eNeuro [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Olfactory bulb;
Cell Type(s): Olfactory bulb main mitral GLU cell; Olfactory bulb main interneuron periglomerular GABA cell; Olfactory bulb main interneuron granule MC GABA cell; Olfactory bulb main interneuron granule TC GABA cell; Olfactory bulb main tufted cell external;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: C or C++ program;
Model Concept(s):
Implementer(s): Linster, Christiane [cl243 at cornell.edu];
Search NeuronDB for information about:  Olfactory bulb main mitral GLU cell; Olfactory bulb main interneuron periglomerular GABA cell; Olfactory bulb main interneuron granule MC GABA cell; Olfactory bulb main interneuron granule TC GABA cell;
#include "cell.init"


WIND DRAW (xmul, outmul, potmul, delta, from_unit)
int xmul, outmul, potmul, delta, from_unit;
{
WIND draw_result;
int x0, x1, help, x, y;
int lasty;
char chain[20];
int unit;
	x0 = 10;
  	x1 = 50;
  	help = 50 + 2 * delta;
  	lasty = HEIGHT;
  	unit = from_unit;
  	CLEAR ();
  	RESET_COOR ();
  	while ((help < lasty) && (unit < N_UNITS))
    		{
      		if (ALL == VRAI)
      	  		{
      	  		if (((D_RECS == FAUX ) && (units[unit].type != receptor)) ||
      	      			(D_RECS == VRAI))
      	      			{
      	      			if (units[unit].type == mitral2)
					strcpy (chain, "m");
				if (units[unit].type == granule)
					strcpy (chain, "g");
				if (units[unit].type == receptor)
					strcpy (chain, "r");
				if (units[unit].type == pyr)
					strcpy (chain, "p");
				if (units[unit].type == ET)
					strcpy (chain, "ET");
				if (units[unit].type == PG)
					strcpy (chain, "PG");
				if (units[unit].type == motor)
					strcpy (chain, "mo");

      	      			TEXT (chain, x0, help);
	      			units[unit].x_coor = x0;
	      			units[unit].y_coor = help;
	      			if (units[unit].selected == VRAI)
					CIRCLE (units[unit].x_coor-5, units[unit].y_coor, 2);
      	      			if (D_OUT == VRAI)
      	      	  			{
      	      	  			if (D_SPIKES == VRAI)
      	      	      				SPIKES (x1, help, xmul, outmul, N_STEPS, units[unit].output);
      	      	  			else
      	      	      				CURVE (x1, help, xmul, outmul, N_STEPS, units[unit].output);
      	      	  			/*AXIS (x1, help, xmul, outmul, N_STEPS, 10);*/
      	      	  			help += delta;
		  			}
      	      			if (D_ACT == VRAI)
      	      	  			{
      	      	  			ACTIVITY (x1, help, xmul, potmul, outmul, N_STEPS, units[unit].state, units[unit].output);  
					
                 			help += delta;
					/*if (units[unit].type == pyr)
						{CURVE (x1, help, xmul, 5*potmul, N_STEPS, units[unit].calcium);
					help += delta;}*/
      	      	  			}
             			if (D_POT == VRAI)
      	      	  			{
      	      	  			CURVE (x1, help, xmul, potmul, N_STEPS, units[unit].state);
      	      	  			/*AXIS (x1, help, xmul, potmul, N_STEPS, 10);*/
      	      	  			help += delta;
      	      	  			}
	    			}
      	  		} /** endif (ALL == VRAI .. **/

      		if ((ALL == FAUX ) && (units[unit].selected == VRAI))
      	      		{
      	      		if (units[unit].type == mitral2)
					strcpy (chain, "m");
			if (units[unit].type == granule)
					strcpy (chain, "g");
			if (units[unit].type == receptor)
					strcpy (chain, "r");
			if (units[unit].type == ET)
					strcpy (chain, "ET");
			if (units[unit].type == PG)
					strcpy (chain, "PG");
			if (units[unit].type == pyr)
					strcpy (chain, "pyr");
			if (units[unit].type == motor)
					strcpy (chain, "mo");
      	      		TEXT (chain, x0, help);
	      		units[unit].x_coor = x0;
	      		units[unit].y_coor = help;
	      		if (units[unit].selected == VRAI)
			CIRCLE (units[unit].x_coor-5, units[unit].y_coor, 2);
      	      		if (D_OUT == VRAI)
      	      	  		{		
      	      	  		if (D_SPIKES == VRAI)
      	      	      			SPIKES (x1, help, xmul, outmul, N_STEPS, units[unit].output);
      	      	  		else
      	      	      			CURVE (x1, help, xmul, outmul, N_STEPS, units[unit].output);
      	      	  		/*AXIS (x1, help, xmul, outmul, N_STEPS, 10);*/
      	      	  		help += delta;
     	      	  		}
      	      		if (D_ACT == VRAI)
      	      	  		{
      	      	  		ACTIVITY (x1, help, xmul, potmul, outmul, N_STEPS, units[unit].state, units[unit].output);            
				help += delta;
				/*if (units[unit].type == pyr)
						{CURVE (x1, help, xmul, 5*potmul, N_STEPS, units[unit].calcium);
				help += delta;}*/

      	      	  		}
            		 if (D_POT == VRAI)
      	      	  		{
      	      	  		CURVE (x1, help, xmul, potmul, N_STEPS, units[unit].state);
      	      	  		/*AXIS (x1, help, xmul, potmul, N_STEPS, 10);*/
      	      	  		help += delta;
      	      	  		}
      	      		} /** endif (ALL == FAUX .. **/      	
      		unit++;
  	 	} /** endwhile (help < lasty .. **/
	
  	CURVE (x1,help, xmul, potmul*2, N_STEPS, POTSM);
	help += 2*delta;
	CURVE (x1,help, xmul, potmul*1, N_STEPS, POTSG);
	help += 2*delta;
	CURVE (x1,help, xmul, potmul*1, N_STEPS, POTSP);
	 
	
  	draw_result.too = unit;
  	TEXT ("click middle : select neuron", 10, 10);
  	TEXT ("click right  : deselect neuron", 10, 25);
  	TEXT ("x : deselect all", 200, 10);
  	TEXT ("s : draw selected", 200, 25);
  	TEXT ("q : quit     u : scroll up  d : scroll down", 500, 10);
  	TEXT ("m : mitral  g : granule  p : pyramidal ", 500, 25);  
  	return (draw_result);
}



void SHOW ()
{
int xmul, outmul, potmul, delta;
EVENT truc;
WIND  vertical[20];
WIND  draw_result;
int   ver, unit;
FILE *read_from;
char to[40];
ALL = VRAI;
printf (" in show first \n");
/** READ DRAW PARAMETERS FROM FILE DRAW.DAT **/

  if ((read_from = fopen ("draw.dat", "r")) == NULL)
    {
      printf (" problem in open file draw.dat \n");
      exit (0);
    }
 loop1:
  if (
      (fscanf (read_from, "%s %d     %s %d       %s %d       %s %d", 
      	      	           to,&xmul, to,&outmul, to,&potmul, to,&delta) != 8) ||


      (fscanf (read_from, "%s %d       %s %d        %s %d      %s %d      %s %d         %s %d", 
      	      	           to,&D_STIM, to, &D_RECS, to,&D_POT, to,&D_OUT, to,&D_SPIKES, to,&D_ACT) != 12) || 

      (fscanf (read_from, "%s %d       %s %d       %s %d ", 
      	      	           to,&D_MPOT, to,&D_MOUT, to,&D_FFTM) != 6) ||
	(fscanf (read_from, "%s %d %s %d", to, &D_VPOT, to, &D_VOUT) != 4) ||
	(fscanf (read_from, "%s %d %s %d %s %d", to, &D_GPOT, to, &D_GOUT, to, &D_FFTG) != 6))
    	
    {
      printf (" problem in reading draw.dat, change and return \n");

      getchar ();
      goto loop1;
    }
  fclose (read_from);
printf ("potmul %d xmul %d \n", potmul, outmul);

printf (" in show second \n");
  vertical[0].from = 0;
  ver = 0;

  CHOOSE_WINDOW (main_window);
  CLEAR ();
/*  truc = GET_EVENT ();*/
  
  draw_result = DRAW (xmul, outmul, potmul, delta, vertical[ver].from);

/** MAIN DRAW LOOP **/

  for (;;)
      {
      truc = GET_EVENT ();
      vertical[ver].too = draw_result.too;  
      if (truc.flag == key)
      	  {
      	  if (EQU (truc.key, "q") == VRAI)
      	      break;
      	  if (EQU (truc.key, "u") == VRAI)
      	      if (vertical[ver].too < N_UNITS)
      	      {
      	      ver += 1;
      	      vertical[ver].from = vertical[ver-1].too;
      	      draw_result = DRAW (xmul, outmul, potmul, delta, vertical[ver].from);    
      	      vertical[ver].too = draw_result.too;
      	      }
      	  if (EQU (truc.key, "d") == VRAI)
      	      if ((vertical[ver].from > 0) && (ver > 0))
      	      	  {
      	      	  ver -= 1;
      	      	  draw_result = DRAW (xmul, outmul, potmul, delta, vertical[ver].from);
      	      	  }
      	  if (EQU (truc.key, "s") == VRAI)
      	      {
      	      ver = 0; 
      	      vertical[ver].from = 0;
      	      ALL = FAUX;
      	      draw_result = DRAW (xmul, outmul, potmul, delta, vertical[ver].from);    
      	      vertical[ver].too = draw_result.too;
      	      }
      	  if (EQU (truc.key, "a") == VRAI)
      	      {
      	      ver = 0; 
      	      vertical[ver].from = 0;
      	      ALL = VRAI;
      	      draw_result = DRAW (xmul, outmul, potmul, delta, vertical[ver].from);    
      	      vertical[ver].too = draw_result.too;
      	      }
      	  if (EQU (truc.key , "x") == VRAI)
      	      DESELECT_ALL ();
     	  if (EQU (truc.key, "m") == VRAI)
      	      {
      	      for (unit = 0; unit < N_UNITS; unit++)
		if (units[unit].type == mitral2)
		  units[unit].selected = VRAI;
	      ver = 0; 
      	      vertical[ver].from = 0;
      	      ALL = FAUX;
      	      draw_result = DRAW (xmul, outmul, potmul, delta, vertical[ver].from);    
      	      vertical[ver].too = draw_result.too;    
	    }
     	  if (EQU (truc.key, "g") == VRAI)
      	      {
      	      for (unit = 0; unit < N_UNITS; unit++)
		if (units[unit].type == granule)
		  units[unit].selected = VRAI;
	      ALL = FAUX;
	      ver = 0; 
      	      vertical[ver].from = 0;
      	      draw_result = DRAW (xmul, outmul, potmul, delta, vertical[ver].from);    
      	      vertical[ver].too = draw_result.too;    
	    }
	if (EQU (truc.key, "e") == VRAI)
      	      {
      	      for (unit = 0; unit < N_UNITS; unit++)
		if (units[unit].type == ET)
		  units[unit].selected = VRAI;
	      ALL = FAUX;
	      ver = 0; 
      	      vertical[ver].from = 0;
      	      draw_result = DRAW (xmul, outmul, potmul, delta, vertical[ver].from);    
      	      vertical[ver].too = draw_result.too;    
	    }
     	  if (EQU (truc.key, "i") == VRAI)
      	      {
      	      for (unit = 0; unit < N_UNITS; unit++)
		if (units[unit].type == PG)
		  units[unit].selected = VRAI;
	      ALL = FAUX;
	      ver = 0; 
      	      vertical[ver].from = 0;
      	      draw_result = DRAW (xmul, outmul, potmul, delta, vertical[ver].from);    
      	      vertical[ver].too = draw_result.too;    
	    }
	if (EQU (truc.key, "p") == VRAI)
      	      {
      	      for (unit = 0; unit < N_UNITS; unit++)
		if (units[unit].type == pyr)
		  units[unit].selected = VRAI;
	      ALL = FAUX;
	      ver = 0; 
      	      vertical[ver].from = 0;
      	      draw_result = DRAW (xmul, outmul, potmul, delta, vertical[ver].from);    
      	      vertical[ver].too = draw_result.too;    
	    }
     	  
      	  } /** endif (truc.flag == **/
      if (truc.flag == mouse)
	{
	  if (truc.button == MIDDLE)
	    SELECT (truc.ypos, potmul, vertical[ver]);
	  if (truc.button == RIGHT)
	    DESELECT (truc.ypos, potmul, vertical[ver]);
	}
    }  /** end (for ;; **/
} /** end show **/

      	          
 /*     
int SHOW_CROSS ()
{
EVENT maus;
	if (cross_window == (Window) NULL)
	  cross_window = OPEN_WINDOW (0, 0, 800, 300, blanc);
	CHOOSE_WINDOW (cross_window);
	CLEAR ();
	for (;;)
	{
	DRAW_CROSS (10, 100, 4, 80, 40, 40);
	maus = GET_EVENT ();
	if (maus.flag == mouse)
		break;
	}
	return (maus.button);
} 
*/	
	      	      
      	      	      	      
      	  
      

  







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