Resurgent Na+ current offers noise modulation in bursting neurons (Venugopal et al 2019)

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Accession:258235
"Neurons utilize bursts of action potentials as an efficient and reliable way to encode information. It is likely that the intrinsic membrane properties of neurons involved in burst generation may also participate in preserving its temporal features. Here we examined the contribution of the persistent and resurgent components of voltage-gated Na+ currents in modulating the burst discharge in sensory neurons. Using mathematical modeling, theory and dynamic-clamp electrophysiology, we show that, distinct from the persistent Na+ component which is important for membrane resonance and burst generation, the resurgent Na+ can help stabilize burst timing features including the duration and intervals. ..."
Reference:
1 . Venugopal S, Seki S, Terman DH, Pantazis A, Olcese R, Wiedau-Pazos M, Chandler SH (2019) Resurgent Na+ Current Offers Noise Modulation in Bursting Neurons. PLoS Comput Biol 15:e1007154 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s): I Na,p; I Na,t;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: MATLAB;
Model Concept(s): Bursting; Action Potentials;
Implementer(s): Venugopal, Sharmila [vsharmila at g.ucla.edu];
Search NeuronDB for information about:  I Na,p; I Na,t;
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MesVModel
readme.txt
BurstingNeuron_SVetal.m
Ina_3HH_Vclamp_SVetal.m
                            
These are the matlab files for the paper:

Venugopal S, Seki S, Terman DH, Pantazis A, Olcese R, Wiedau-Pazos M,
Chandler SH (2019) Resurgent Na+ Current Offers Noise Modulation in
Bursting Neurons. PLoS Comput Biol 15:e1007154

These files were supplied by S Venugopal.

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