//genesis
/* FILE INFORMATION
** "Generic" excitatory (glutamate) and inhibitory (GABA) synaptically
** activated channels (based on mitsyn.g by Upi Bhalla)
**
** The channels have an alpha_function type conductance change for
** each synaptic event.
**
** Modified by D. Beeman for GENESIS 2.0 syntax and synchan object - 5/19/94
*/
// CONSTANTS
float EGlu = 0.0
float EGABA = -0.081
float SOMA_A = 1e-9
float GGlu = SOMA_A * 50
float GGABA = SOMA_A * 50
// CONSTANTS for NMDA Channel
float CMg = 1.5 // [Mg] in mM
float eta = 0.33 // per mM
float gamma = 60 // per Volt
//===================================================================
// SYNAPTIC CHANNELS (Values guessed at)
//===================================================================
function make_Ex_ch4P23RSAMPAlongrange
// AMPA synapse for P23RS - P23RS
if ({exists Ex_ch4P23RSAMPAlongrange})
return
end
create synchan Ex_ch4P23RSAMPAlongrange
setfield Ex_ch4P23RSAMPAlongrange \
Ek {EGlu} \
tau1 { 2.0e-3 } \ // sec
tau2 { 2.0e-3 } \ // sec
gmax {GGlu} // Siemens
end
function make_Ex_ch4P23RSNMDAlongrange
// NMDA synapse for P23RS - P23RS
if ({exists Ex_ch4P23RSNMDAlongrange})
return
end
create synchan Ex_ch4P23RSNMDAlongrange
setfield Ex_ch4P23RSNMDAlongrange \
Ek {EGlu} \
tau2 { 0.67e-3 } \ // sec
tau1 { 130.0e-3 } \ // sec
gmax {GGlu} // Siemens
create Mg_block Ex_ch4P23RSNMDAlongrange/block
setfield Ex_ch4P23RSNMDAlongrange/block \
CMg {CMg} \
KMg_A {1.0/eta} \
KMg_B {1.0/gamma}
addmsg Ex_ch4P23RSNMDAlongrange Ex_ch4P23RSNMDA/block CHANNEL Gk Ek
addmsg Ex_ch4P23RSNMDAlongrange/block . CHANNEL Gk Ek
addmsg . Ex_ch4P23RSNMDAlongrange/block VOLTAGE Vm
// Even though we don't use the channel current, CHECK expects this message.
// addmsg . Ex_ch4P23RSNMDAlongrange VOLTAGE Vm
end
function make_Inh_ch4B23FSGABAalongrange
//GABA_A synapse for B23FS - P23RS
if ({exists Inh_ch4B23FSGABAalongrange})
return
end
create synchan Inh_ch4B23FSGABAalongrange
setfield Inh_ch4B23FSGABAalongrange \
Ek { EGABA } \
tau1 { 6.0e-3 } \ // sec
tau2 { 1.0e-12 } \ // sec
gmax {GGABA} // Siemens
end
function make_Ex_ch4P5IBAMPAlongrange
// AMPA synapse for P5IB - P23RS
if ({exists Ex_ch4P5IBAMPAlongrange})
return
end
create synchan Ex_ch4P5IBAMPAlongrange
setfield Ex_ch4P5IBAMPAlongrange \
Ek {EGlu} \
tau1 { 2.0e-3 } \ // sec
tau2 { 2.0e-3 } \ // sec
gmax {GGlu} // Siemens
end
function make_Ex_ch4P5IBNMDAlongrange
// NMDA synapse for P5IB - P23RS
if ({exists Ex_ch4P5IBNMDAlongrange})
return
end
create synchan Ex_ch4P5IBNMDAlongrange
setfield Ex_ch4P5IBNMDAlongrange \
Ek {EGlu} \
tau2 { 0.67e-3 } \ // sec
tau1 { 130.0e-3 } \ // sec
gmax {GGlu} // Siemens
create Mg_block Ex_ch4P5IBNMDAlongrange/block
setfield Ex_ch4P5IBNMDAlongrange/block \
CMg {CMg} \
KMg_A {1.0/eta} \
KMg_B {1.0/gamma}
addmsg Ex_ch4P5IBNMDAlongrange Ex_ch4P5IBNMDA/block CHANNEL Gk Ek
addmsg Ex_ch4P5IBNMDAlongrange/block . CHANNEL Gk Ek
addmsg . Ex_ch4P5IBNMDAlongrange/block VOLTAGE Vm
// Even though we don't use the channel current, CHECK expects this message.
// addmsg . Ex_ch4P5IBNMDAlongrange VOLTAGE Vm
end
function make_Ex_ch4P6RSAMPAlongrange
// AMPA synapse for P6RS - P23RS
if ({exists Ex_ch4P6RSAMPAlongrange})
return
end
create synchan Ex_ch4P6RSAMPAlongrange
setfield Ex_ch4P6RSAMPAlongrange \
Ek {EGlu} \
tau1 { 2.0e-3 } \ // sec
tau2 { 2.0e-3 } \ // sec
gmax {GGlu} // Siemens
end
function make_Ex_ch4P6RSNMDAlongrange
// NMDA synapse for P6RS - P23RS
if ({exists Ex_ch4P6RSNMDAlongrange})
return
end
create synchan Ex_ch4P6RSNMDAlongrange
setfield Ex_ch4P6RSNMDAlongrange \
Ek {EGlu} \
tau2 { 0.67e-3 } \ // sec
tau1 { 130.0e-3 } \ // sec
gmax {GGlu} // Siemens
create Mg_block Ex_ch4P6RSNMDAlongrange/block
setfield Ex_ch4P6RSNMDAlongrange/block \
CMg {CMg} \
KMg_A {1.0/eta} \
KMg_B {1.0/gamma}
addmsg Ex_ch4P6RSNMDAlongrange Ex_ch4P6RSNMDA/block CHANNEL Gk Ek
addmsg Ex_ch4P6RSNMDAlongrange/block . CHANNEL Gk Ek
addmsg . Ex_ch4P6RSNMDAlongrange/block VOLTAGE Vm
// Even though we don't use the channel current, CHECK expects this message.
// addmsg . Ex_ch4P6RSNMDAlongrange VOLTAGE Vm
end
function make_Inh_ch4C23FSGABAalongrange
//GABA_A synapse for C23FS - P23RS
if ({exists Inh_ch4C23FSGABAalongrange})
return
end
create synchan Inh_ch4C23FSGABAalongrange
setfield Inh_ch4C23FSGABAalongrange \
Ek { EGABA } \
tau1 { 6.0e-3 } \ // sec
tau2 { 1.0e-12 } \ // sec
gmax {GGABA} // Siemens
end
function make_Inh_ch4C5FSGABAalongrange
//GABA_A synapse for C5FS - P23RS
if ({exists Inh_ch4C5FSGABAalongrange})
return
end
create synchan Inh_ch4C5FSGABAalongrange
setfield Inh_ch4C5FSGABAalongrange \
Ek { EGABA } \
tau1 { 6.0e-3 } \ // sec
tau2 { 1.0e-12 } \ // sec
gmax {GGABA} // Siemens
end
function make_Ex_ch4ST4RSAMPAlongrange
// AMPA synapse for ST4RS - P23RS
if ({exists Ex_ch4ST4RSAMPAlongrange})
return
end
create synchan Ex_ch4ST4RSAMPAlongrange
setfield Ex_ch4ST4RSAMPAlongrange \
Ek {EGlu} \
tau1 { 2.0e-3 } \ // sec
tau2 { 2.0e-3 } \ // sec
gmax {GGlu} // Siemens
end
function make_Ex_ch4ST4RSNMDAlongrange
// NMDA synapse for ST4RS - P23RS
if ({exists Ex_ch4ST4RSNMDAlongrange})
return
end
create synchan Ex_ch4ST4RSNMDAlongrange
setfield Ex_ch4ST4RSNMDAlongrange \
Ek {EGlu} \
tau2 { 0.67e-3 } \ // sec
tau1 { 130.0e-3 } \ // sec
gmax {GGlu} // Siemens
create Mg_block Ex_ch4ST4RSNMDAlongrange/block
setfield Ex_ch4ST4RSNMDAlongrange/block \
CMg {CMg} \
KMg_A {1.0/eta} \
KMg_B {1.0/gamma}
addmsg Ex_ch4ST4RSNMDAlongrange Ex_ch4ST4RSNMDA/block CHANNEL Gk Ek
addmsg Ex_ch4ST4RSNMDAlongrange/block . CHANNEL Gk Ek
addmsg . Ex_ch4ST4RSNMDAlongrange/block VOLTAGE Vm
// Even though we don't use the channel current, CHECK expects this message.
// addmsg . Ex_ch4ST4RSNMDAlongrange VOLTAGE Vm
end
function make_Inh_ch4I23LTSGABAalongrange
//GABA_A synapse for I23LTS - P23RS
if ({exists Inh_ch4I23LTSGABAalongrange})
return
end
create synchan Inh_ch4I23LTSGABAalongrange
setfield Inh_ch4I23LTSGABAalongrange \
Ek { EGABA } \
tau1 { 20.0e-3 } \ // sec
tau2 { 1.0e-12 } \ // sec
gmax {GGABA} // Siemens
end
function make_Inh_ch4I5LTSGABAalongrange
//GABA_A synapse for I5LTS - P23RS
if ({exists Inh_ch4I5LTSGABAalongrange})
return
end
create synchan Inh_ch4I5LTSGABAalongrange
setfield Inh_ch4I5LTSGABAalongrange \
Ek { EGABA } \
tau1 { 20.0e-3 } \ // sec
tau2 { 1.0e-12 } \ // sec
gmax {GGABA} // Siemens
end
function make_Ex_ch4TCRAMPAlongrange
// AMPA synapse for TCR - P23RS
if ({exists Ex_ch4TCRAMPAlongrange})
return
end
create synchan Ex_ch4TCRAMPAlongrange
setfield Ex_ch4TCRAMPAlongrange \
Ek {EGlu} \
tau1 { 2.0e-3 } \ // sec
tau2 { 2.0e-3 } \ // sec
gmax {GGlu} // Siemens
end
function make_Ex_ch4TCRNMDAlongrange
// NMDA synapse for TCR - P23RS
if ({exists Ex_ch4TCRNMDAlongrange})
return
end
create synchan Ex_ch4TCRNMDAlongrange
setfield Ex_ch4TCRNMDAlongrange \
Ek {EGlu} \
tau2 { 0.67e-3 } \ // sec
tau1 { 130.0e-3 } \ // sec
gmax {GGlu} // Siemens
create Mg_block Ex_ch4TCRNMDAlongrange/block
setfield Ex_ch4TCRNMDAlongrange/block \
CMg {CMg} \
KMg_A {1.0/eta} \
KMg_B {1.0/gamma}
addmsg Ex_ch4TCRNMDAlongrange Ex_ch4TCRNMDA/block CHANNEL Gk Ek
addmsg Ex_ch4TCRNMDAlongrange/block . CHANNEL Gk Ek
addmsg . Ex_ch4TCRNMDAlongrange/block VOLTAGE Vm
// Even though we don't use the channel current, CHECK expects this message.
// addmsg . Ex_ch4TCRNMDAlongrange VOLTAGE Vm
end
function make_Ex_ch4TCRAMPAlongrange
// AMPA synapse for TCR - P23RS
if ({exists Ex_ch4TCRAMPAlongrange})
return
end
create synchan Ex_ch4TCRAMPAlongrange
setfield Ex_ch4TCRAMPAlongrange \
Ek {EGlu} \
tau1 { 2.0e-3 } \ // sec
tau2 { 2.0e-3 } \ // sec
gmax {GGlu} // Siemens
end
function make_Ex_ch4TCRNMDAlongrange
// NMDA synapse for TCR - P23RS
if ({exists Ex_ch4TCRNMDAlongrange})
return
end
create synchan Ex_ch4TCRNMDAlongrange
setfield Ex_ch4TCRNMDAlongrange \
Ek {EGlu} \
tau2 { 0.67e-3 } \ // sec
tau1 { 130.0e-3 } \ // sec
gmax {GGlu} // Siemens
create Mg_block Ex_ch4TCRNMDAlongrange/block
setfield Ex_ch4TCRNMDAlongrange/block \
CMg {CMg} \
KMg_A {1.0/eta} \
KMg_B {1.0/gamma}
addmsg Ex_ch4TCRNMDAlongrange Ex_ch4TCRNMDA/block CHANNEL Gk Ek
addmsg Ex_ch4TCRNMDAlongrange/block . CHANNEL Gk Ek
addmsg . Ex_ch4TCRNMDAlongrange/block VOLTAGE Vm
// Even though we don't use the channel current, CHECK expects this message.
// addmsg . Ex_ch4TCRNMDAlongrange VOLTAGE Vm
end
function make_Ex_ch4P23FRBAMPAlongrange
// AMPA synapse for P23FRB - P23RS
if ({exists Ex_ch4P23FRBAMPAlongrange})
return
end
create synchan Ex_ch4P23FRBAMPAlongrange
setfield Ex_ch4P23FRBAMPAlongrange \
Ek {EGlu} \
tau1 { 2.0e-3 } \ // sec
tau2 { 2.0e-3 } \ // sec
gmax {GGlu} // Siemens
end
function make_Ex_ch4P23FRBNMDAlongrange
// NMDA synapse for P23FRB - P23RS
if ({exists Ex_ch4P23FRBNMDAlongrange})
return
end
create synchan Ex_ch4P23FRBNMDAlongrange
setfield Ex_ch4P23FRBNMDAlongrange \
Ek {EGlu} \
tau2 { 0.67e-3 } \ // sec
tau1 { 130.0e-3 } \ // sec
gmax {GGlu} // Siemens
create Mg_block Ex_ch4P23FRBNMDAlongrange/block
setfield Ex_ch4P23FRBNMDAlongrange/block \
CMg {CMg} \
KMg_A {1.0/eta} \
KMg_B {1.0/gamma}
addmsg Ex_ch4P23FRBNMDAlongrange Ex_ch4P23FRBNMDA/block CHANNEL Gk Ek
addmsg Ex_ch4P23FRBNMDAlongrange/block . CHANNEL Gk Ek
addmsg . Ex_ch4P23FRBNMDAlongrange/block VOLTAGE Vm
// Even though we don't use the channel current, CHECK expects this message.
// addmsg . Ex_ch4P23FRBNMDAlongrange VOLTAGE Vm
end
function make_Ex_ch4P5RSAMPAlongrange
// AMPA synapse for P5RS - P23RS
if ({exists Ex_ch4P5RSAMPAlongrange})
return
end
create synchan Ex_ch4P5RSAMPAlongrange
setfield Ex_ch4P5RSAMPAlongrange \
Ek {EGlu} \
tau1 { 2.0e-3 } \ // sec
tau2 { 2.0e-3 } \ // sec
gmax {GGlu} // Siemens
end
function make_Ex_ch4P5RSNMDAlongrange
// NMDA synapse for P5RS - P23RS
if ({exists Ex_ch4P5RSNMDAlongrange})
return
end
create synchan Ex_ch4P5RSNMDAlongrange
setfield Ex_ch4P5RSNMDAlongrange \
Ek {EGlu} \
tau2 { 0.67e-3 } \ // sec
tau1 { 130.0e-3 } \ // sec
gmax {GGlu} // Siemens
create Mg_block Ex_ch4P5RSNMDAlongrange/block
setfield Ex_ch4P5RSNMDAlongrange/block \
CMg {CMg} \
KMg_A {1.0/eta} \
KMg_B {1.0/gamma}
addmsg Ex_ch4P5RSNMDAlongrange Ex_ch4P5RSNMDA/block CHANNEL Gk Ek
addmsg Ex_ch4P5RSNMDAlongrange/block . CHANNEL Gk Ek
addmsg . Ex_ch4P5RSNMDAlongrange/block VOLTAGE Vm
// Even though we don't use the channel current, CHECK expects this message.
// addmsg . Ex_ch4P5RSNMDAlongrange VOLTAGE Vm
end
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