//genesis
/* FILE INFORMATION
** "Generic" excitatory (glutamate) and inhibitory (GABA) synaptically
** activated channels (based on mitsyn.g by Upi Bhalla)
**
** The channels have an alpha_function type conductance change for
** each synaptic event.
**
** Modified by D. Beeman for GENESIS 2.0 syntax and synchan object - 5/19/94
*/
// CONSTANTS
float EGlu = 0.0
float EGABA = -0.081
float SOMA_A = 1e-9
float GGlu = SOMA_A * 50
float GGABA = SOMA_A * 50
// CONSTANTS for NMDA Channel
float CMg = 1.5 // [Mg] in mM
float eta = 0.33 // per mM
float gamma = 60 // per Volt
//===================================================================
// SYNAPTIC CHANNELS (Values guessed at)
//===================================================================
function make_Ex_ch12P23RSAMPA
// AMPA synapse for P23RS - P6RS
if ({exists Ex_ch12P23RSAMPA})
return
end
create synchan Ex_ch12P23RSAMPA
setfield Ex_ch12P23RSAMPA \
Ek {EGlu} \
tau1 { 2.0e-3 } \ // sec
tau2 { 2.0e-3 } \ // sec
gmax {GGlu} // Siemens
end
function make_Ex_ch12P23RSNMDA
// NMDA synapse for P23RS - P6RS
if ({exists Ex_ch12P23RSNMDA})
return
end
create synchan Ex_ch12P23RSNMDA
setfield Ex_ch12P23RSNMDA \
Ek {EGlu} \
tau2 { 0.67e-3 } \ // sec
tau1 { 130.0e-3 } \ // sec
gmax {GGlu} // Siemens
create Mg_block Ex_ch12P23RSNMDA/block
setfield Ex_ch12P23RSNMDA/block \
CMg {CMg} \
KMg_A {1.0/eta} \
KMg_B {1.0/gamma}
addmsg Ex_ch12P23RSNMDA Ex_ch12P23RSNMDA/block CHANNEL Gk Ek
addmsg Ex_ch12P23RSNMDA/block . CHANNEL Gk Ek
addmsg . Ex_ch12P23RSNMDA/block VOLTAGE Vm
// Even though we don't use the channel current, CHECK expects this message.
// addmsg . Ex_ch12P23RSNMDA VOLTAGE Vm
end
function make_Ex_ch12P5IBAMPA
// AMPA synapse for P5IB - P6RS
if ({exists Ex_ch12P5IBAMPA})
return
end
create synchan Ex_ch12P5IBAMPA
setfield Ex_ch12P5IBAMPA \
Ek {EGlu} \
tau1 { 2.0e-3 } \ // sec
tau2 { 2.0e-3 } \ // sec
gmax {GGlu} // Siemens
end
function make_Ex_ch12P5IBNMDA
// NMDA synapse for P5IB - P6RS
if ({exists Ex_ch12P5IBNMDA})
return
end
create synchan Ex_ch12P5IBNMDA
setfield Ex_ch12P5IBNMDA \
Ek {EGlu} \
tau2 { 0.67e-3 } \ // sec
tau1 { 130.0e-3 } \ // sec
gmax {GGlu} // Siemens
create Mg_block Ex_ch12P5IBNMDA/block
setfield Ex_ch12P5IBNMDA/block \
CMg {CMg} \
KMg_A {1.0/eta} \
KMg_B {1.0/gamma}
addmsg Ex_ch12P5IBNMDA Ex_ch12P5IBNMDA/block CHANNEL Gk Ek
addmsg Ex_ch12P5IBNMDA/block . CHANNEL Gk Ek
addmsg . Ex_ch12P5IBNMDA/block VOLTAGE Vm
// Even though we don't use the channel current, CHECK expects this message.
// addmsg . Ex_ch12P5IBNMDA VOLTAGE Vm
end
function make_Inh_ch12B5FSGABAa
//GABA_A synapse for B5FS - P6RS
if ({exists Inh_ch12B5FSGABAa})
return
end
create synchan Inh_ch12B5FSGABAa
setfield Inh_ch12B5FSGABAa \
Ek { EGABA } \
tau1 { 6.0e-3 } \ // sec
tau2 { 1.0e-12 } \ // sec
gmax {GGABA} // Siemens
end
function make_Ex_ch12P6RSAMPA
// AMPA synapse for P6RS - P6RS
if ({exists Ex_ch12P6RSAMPA})
return
end
create synchan Ex_ch12P6RSAMPA
setfield Ex_ch12P6RSAMPA \
Ek {EGlu} \
tau1 { 2.0e-3 } \ // sec
tau2 { 2.0e-3 } \ // sec
gmax {GGlu} // Siemens
end
function make_Ex_ch12P6RSNMDA
// NMDA synapse for P6RS - P6RS
if ({exists Ex_ch12P6RSNMDA})
return
end
create synchan Ex_ch12P6RSNMDA
setfield Ex_ch12P6RSNMDA \
Ek {EGlu} \
tau2 { 0.67e-3 } \ // sec
tau1 { 130.0e-3 } \ // sec
gmax {GGlu} // Siemens
create Mg_block Ex_ch12P6RSNMDA/block
setfield Ex_ch12P6RSNMDA/block \
CMg {CMg} \
KMg_A {1.0/eta} \
KMg_B {1.0/gamma}
addmsg Ex_ch12P6RSNMDA Ex_ch12P6RSNMDA/block CHANNEL Gk Ek
addmsg Ex_ch12P6RSNMDA/block . CHANNEL Gk Ek
addmsg . Ex_ch12P6RSNMDA/block VOLTAGE Vm
// Even though we don't use the channel current, CHECK expects this message.
// addmsg . Ex_ch12P6RSNMDA VOLTAGE Vm
end
function make_Inh_ch12C23FSGABAa
//GABA_A synapse for C23FS - P6RS
if ({exists Inh_ch12C23FSGABAa})
return
end
create synchan Inh_ch12C23FSGABAa
setfield Inh_ch12C23FSGABAa \
Ek { EGABA } \
tau1 { 6.0e-3 } \ // sec
tau2 { 1.0e-12 } \ // sec
gmax {GGABA} // Siemens
end
function make_Inh_ch12C5FSGABAa
//GABA_A synapse for C5FS - P6RS
if ({exists Inh_ch12C5FSGABAa})
return
end
create synchan Inh_ch12C5FSGABAa
setfield Inh_ch12C5FSGABAa \
Ek { EGABA } \
tau1 { 6.0e-3 } \ // sec
tau2 { 1.0e-12 } \ // sec
gmax {GGABA} // Siemens
end
function make_Ex_ch12ST4RSAMPA
// AMPA synapse for ST4RS - P6RS
if ({exists Ex_ch12ST4RSAMPA})
return
end
create synchan Ex_ch12ST4RSAMPA
setfield Ex_ch12ST4RSAMPA \
Ek {EGlu} \
tau1 { 2.0e-3 } \ // sec
tau2 { 2.0e-3 } \ // sec
gmax {GGlu} // Siemens
end
function make_Ex_ch12ST4RSNMDA
// NMDA synapse for ST4RS - P6RS
if ({exists Ex_ch12ST4RSNMDA})
return
end
create synchan Ex_ch12ST4RSNMDA
setfield Ex_ch12ST4RSNMDA \
Ek {EGlu} \
tau2 { 0.67e-3 } \ // sec
tau1 { 130.0e-3 } \ // sec
gmax {GGlu} // Siemens
create Mg_block Ex_ch12ST4RSNMDA/block
setfield Ex_ch12ST4RSNMDA/block \
CMg {CMg} \
KMg_A {1.0/eta} \
KMg_B {1.0/gamma}
addmsg Ex_ch12ST4RSNMDA Ex_ch12ST4RSNMDA/block CHANNEL Gk Ek
addmsg Ex_ch12ST4RSNMDA/block . CHANNEL Gk Ek
addmsg . Ex_ch12ST4RSNMDA/block VOLTAGE Vm
// Even though we don't use the channel current, CHECK expects this message.
// addmsg . Ex_ch12ST4RSNMDA VOLTAGE Vm
end
function make_Inh_ch12I23LTSGABAa
//GABA_A synapse for I23LTS - P6RS
if ({exists Inh_ch12I23LTSGABAa})
return
end
create synchan Inh_ch12I23LTSGABAa
setfield Inh_ch12I23LTSGABAa \
Ek { EGABA } \
tau1 { 20.0e-3 } \ // sec
tau2 { 1.0e-12 } \ // sec
gmax {GGABA} // Siemens
end
function make_Inh_ch12I5LTSGABAa
//GABA_A synapse for I5LTS - P6RS
if ({exists Inh_ch12I5LTSGABAa})
return
end
create synchan Inh_ch12I5LTSGABAa
setfield Inh_ch12I5LTSGABAa \
Ek { EGABA } \
tau1 { 20.0e-3 } \ // sec
tau2 { 1.0e-12 } \ // sec
gmax {GGABA} // Siemens
end
function make_Ex_ch12TCRAMPA
// AMPA synapse for TCR - P6RS
if ({exists Ex_ch12TCRAMPA})
return
end
create synchan Ex_ch12TCRAMPA
setfield Ex_ch12TCRAMPA \
Ek {EGlu} \
tau1 { 2.0e-3 } \ // sec
tau2 { 2.0e-3 } \ // sec
gmax {GGlu} // Siemens
end
function make_Ex_ch12TCRNMDA
// NMDA synapse for TCR - P6RS
if ({exists Ex_ch12TCRNMDA})
return
end
create synchan Ex_ch12TCRNMDA
setfield Ex_ch12TCRNMDA \
Ek {EGlu} \
tau2 { 0.67e-3 } \ // sec
tau1 { 130.0e-3 } \ // sec
gmax {GGlu} // Siemens
create Mg_block Ex_ch12TCRNMDA/block
setfield Ex_ch12TCRNMDA/block \
CMg {CMg} \
KMg_A {1.0/eta} \
KMg_B {1.0/gamma}
addmsg Ex_ch12TCRNMDA Ex_ch12TCRNMDA/block CHANNEL Gk Ek
addmsg Ex_ch12TCRNMDA/block . CHANNEL Gk Ek
addmsg . Ex_ch12TCRNMDA/block VOLTAGE Vm
// Even though we don't use the channel current, CHECK expects this message.
// addmsg . Ex_ch12TCRNMDA VOLTAGE Vm
end
function make_Ex_ch12TCRAMPA
// AMPA synapse for TCR - P6RS
if ({exists Ex_ch12TCRAMPA})
return
end
create synchan Ex_ch12TCRAMPA
setfield Ex_ch12TCRAMPA \
Ek {EGlu} \
tau1 { 2.0e-3 } \ // sec
tau2 { 2.0e-3 } \ // sec
gmax {GGlu} // Siemens
end
function make_Ex_ch12TCRNMDA
// NMDA synapse for TCR - P6RS
if ({exists Ex_ch12TCRNMDA})
return
end
create synchan Ex_ch12TCRNMDA
setfield Ex_ch12TCRNMDA \
Ek {EGlu} \
tau2 { 0.67e-3 } \ // sec
tau1 { 130.0e-3 } \ // sec
gmax {GGlu} // Siemens
create Mg_block Ex_ch12TCRNMDA/block
setfield Ex_ch12TCRNMDA/block \
CMg {CMg} \
KMg_A {1.0/eta} \
KMg_B {1.0/gamma}
addmsg Ex_ch12TCRNMDA Ex_ch12TCRNMDA/block CHANNEL Gk Ek
addmsg Ex_ch12TCRNMDA/block . CHANNEL Gk Ek
addmsg . Ex_ch12TCRNMDA/block VOLTAGE Vm
// Even though we don't use the channel current, CHECK expects this message.
// addmsg . Ex_ch12TCRNMDA VOLTAGE Vm
end
function make_Ex_ch12P23FRBAMPA
// AMPA synapse for P23FRB - P6RS
if ({exists Ex_ch12P23FRBAMPA})
return
end
create synchan Ex_ch12P23FRBAMPA
setfield Ex_ch12P23FRBAMPA \
Ek {EGlu} \
tau1 { 2.0e-3 } \ // sec
tau2 { 2.0e-3 } \ // sec
gmax {GGlu} // Siemens
end
function make_Ex_ch12P23FRBNMDA
// NMDA synapse for P23FRB - P6RS
if ({exists Ex_ch12P23FRBNMDA})
return
end
create synchan Ex_ch12P23FRBNMDA
setfield Ex_ch12P23FRBNMDA \
Ek {EGlu} \
tau2 { 0.67e-3 } \ // sec
tau1 { 130.0e-3 } \ // sec
gmax {GGlu} // Siemens
create Mg_block Ex_ch12P23FRBNMDA/block
setfield Ex_ch12P23FRBNMDA/block \
CMg {CMg} \
KMg_A {1.0/eta} \
KMg_B {1.0/gamma}
addmsg Ex_ch12P23FRBNMDA Ex_ch12P23FRBNMDA/block CHANNEL Gk Ek
addmsg Ex_ch12P23FRBNMDA/block . CHANNEL Gk Ek
addmsg . Ex_ch12P23FRBNMDA/block VOLTAGE Vm
// Even though we don't use the channel current, CHECK expects this message.
// addmsg . Ex_ch12P23FRBNMDA VOLTAGE Vm
end
function make_Ex_ch12P5RSAMPA
// AMPA synapse for P5RS - P6RS
if ({exists Ex_ch12P5RSAMPA})
return
end
create synchan Ex_ch12P5RSAMPA
setfield Ex_ch12P5RSAMPA \
Ek {EGlu} \
tau1 { 2.0e-3 } \ // sec
tau2 { 2.0e-3 } \ // sec
gmax {GGlu} // Siemens
end
function make_Ex_ch12P5RSNMDA
// NMDA synapse for P5RS - P6RS
if ({exists Ex_ch12P5RSNMDA})
return
end
create synchan Ex_ch12P5RSNMDA
setfield Ex_ch12P5RSNMDA \
Ek {EGlu} \
tau2 { 0.67e-3 } \ // sec
tau1 { 130.0e-3 } \ // sec
gmax {GGlu} // Siemens
create Mg_block Ex_ch12P5RSNMDA/block
setfield Ex_ch12P5RSNMDA/block \
CMg {CMg} \
KMg_A {1.0/eta} \
KMg_B {1.0/gamma}
addmsg Ex_ch12P5RSNMDA Ex_ch12P5RSNMDA/block CHANNEL Gk Ek
addmsg Ex_ch12P5RSNMDA/block . CHANNEL Gk Ek
addmsg . Ex_ch12P5RSNMDA/block VOLTAGE Vm
// Even though we don't use the channel current, CHECK expects this message.
// addmsg . Ex_ch12P5RSNMDA VOLTAGE Vm
end
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