Thalamocortical control of propofol phase-amplitude coupling (Soplata et al 2017)

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Accession:260960
"The anesthetic propofol elicits many different spectral properties on the EEG, including alpha oscillations (8-12 Hz), Slow Wave Oscillations (SWO, 0.1-1.5 Hz), and dose-dependent phase-amplitude coupling (PAC) between alpha and SWO. Propofol is known to increase GABAA inhibition and decrease H-current strength, but how it generates these rhythms and their interactions is still unknown. To investigate both generation of the alpha rhythm and its PAC to SWO, we simulate a Hodgkin-Huxley network model of a hyperpolarized thalamus and corticothalamic inputs. ..."
Reference:
1 . Soplata AE, McCarthy MM, Sherfey J, Lee S, Purdon PL, Brown EN, Kopell N (2017) Thalamocortical control of propofol phase-amplitude coupling. PLoS Comput Biol 13:e1005879 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Thalamus;
Cell Type(s): Hodgkin-Huxley neuron;
Channel(s): I Potassium; I h; I Na,t; I Calcium;
Gap Junctions:
Receptor(s): GabaA; AMPA; GabaB;
Gene(s):
Transmitter(s): Gaba;
Simulation Environment: DynaSim;
Model Concept(s): Action Potentials; Oscillations; Activity Patterns;
Implementer(s):
Search NeuronDB for information about:  GabaA; GabaB; AMPA; I Na,t; I h; I Calcium; I Potassium; Gaba;
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