/*
Copyright (c) 2015 EPFL-BBP, All rights reserved.
THIS SOFTWARE IS PROVIDED BY THE BLUE BRAIN PROJECT ``AS IS''
AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO,
THE IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR
PURPOSE ARE DISCLAIMED. IN NO EVENT SHALL THE BLUE BRAIN PROJECT
BE LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR
CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF
SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR
BUSINESS INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY,
WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE
OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN
IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE.
This work is licensed under a
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
To view a copy of this license, visit
http://creativecommons.org/licenses/by-nc-sa/4.0/legalcode or send a letter to
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*/
/*
* @file biophys.hoc
* @brief Biophysics
* @author Etay Hay, Werner Van Geit @ BBP
* @date 2015
*/
begintemplate cADpyr229_biophys
public biophys, distribute
proc distribute(){local x localobj sl
strdef stmp,distfunc,mech
sl = $o1
mech = $s2
distfunc = $s3
sprint(distfunc,"%%s %s(%%f) = %s",mech, distfunc)
forsec sl for(x) {
sprint (stmp,distfunc,secname(),x,distance(x))
execute(stmp)
}
}
proc biophys() {
forsec $o1.basal {
insert Ih
}
forsec $o1.apical {
insert Im
insert NaTs2_t
insert SKv3_1
insert Ih
}
forsec $o1.somatic {
insert Ca_HVA
insert SKv3_1
insert SK_E2
insert Ca_LVAst
insert Ih
insert NaTs2_t
insert CaDynamics_E2
}
forsec $o1.axonal {
insert Ca_HVA
insert SKv3_1
insert SK_E2
insert CaDynamics_E2
insert Nap_Et2
insert K_Pst
insert K_Tst
insert Ca_LVAst
insert NaTa_t
}
forsec $o1.all {
insert pas
}
forsec $o1.all {
e_pas = -75
}
forsec $o1.all {
Ra = 100
}
forsec $o1.all {
cm = 1
}
forsec $o1.all {
g_pas = 3e-5
}
forsec $o1.apical {
ena = 50
}
forsec $o1.apical {
ek = -85
}
forsec $o1.apical {
cm = 2
}
forsec $o1.axonal {
ena = 50
}
forsec $o1.axonal {
ek = -85
}
forsec $o1.basal {
cm = 2
}
forsec $o1.somatic {
ena = 50
}
forsec $o1.somatic {
ek = -85
}
distribute($o1.basal,"gIhbar_Ih","(0.0 * %g + 1.0)*0.000080")
distribute($o1.apical,"gNaTs2_tbar_NaTs2_t","(0.0 * %g + 1.0)*0.012009")
distribute($o1.apical,"gSKv3_1bar_SKv3_1","(0.0 * %g + 1.0)*0.000513")
distribute($o1.apical,"gIhbar_Ih","(-0.869600 + 2.087000*exp((%g-0.000000)*0.003100))*0.000080")
distribute($o1.apical,"gImbar_Im","(0.0 * %g + 1.0)*0.000740")
distribute($o1.axonal,"gNaTa_tbar_NaTa_t","(0.0 * %g + 1.0)*3.429725")
distribute($o1.axonal,"gK_Tstbar_K_Tst","(0.0 * %g + 1.0)*0.001035")
distribute($o1.axonal,"gamma_CaDynamics_E2","(0.0 * %g + 1.0)*0.016713")
distribute($o1.axonal,"gNap_Et2bar_Nap_Et2","(0.0 * %g + 1.0)*0.009803")
distribute($o1.axonal,"gSK_E2bar_SK_E2","(0.0 * %g + 1.0)*0.008085")
distribute($o1.axonal,"gCa_HVAbar_Ca_HVA","(0.0 * %g + 1.0)*0.000306")
distribute($o1.axonal,"gK_Pstbar_K_Pst","(0.0 * %g + 1.0)*0.959296")
distribute($o1.axonal,"gSKv3_1bar_SKv3_1","(0.0 * %g + 1.0)*0.094971")
distribute($o1.axonal,"decay_CaDynamics_E2","(0.0 * %g + 1.0)*384.114655")
distribute($o1.axonal,"gCa_LVAstbar_Ca_LVAst","(0.0 * %g + 1.0)*0.000050")
distribute($o1.somatic,"gamma_CaDynamics_E2","(0.0 * %g + 1.0)*0.000533")
distribute($o1.somatic,"gSKv3_1bar_SKv3_1","(0.0 * %g + 1.0)*0.102517")
distribute($o1.somatic,"gSK_E2bar_SK_E2","(0.0 * %g + 1.0)*0.099433")
distribute($o1.somatic,"gCa_HVAbar_Ca_HVA","(0.0 * %g + 1.0)*0.000374")
distribute($o1.somatic,"gNaTs2_tbar_NaTs2_t","(0.0 * %g + 1.0)*0.926705")
distribute($o1.somatic,"gIhbar_Ih","(0.0 * %g + 1.0)*0.000080")
distribute($o1.somatic,"decay_CaDynamics_E2","(0.0 * %g + 1.0)*342.544232")
distribute($o1.somatic,"gCa_LVAstbar_Ca_LVAst","(0.0 * %g + 1.0)*0.000778")
}
endtemplate cADpyr229_biophys