Biochemically detailed model of LTP and LTD in a cortical spine (Maki-Marttunen et al 2020)

 Download zip file 
Help downloading and running models
Accession:260971
"Signalling pathways leading to post-synaptic plasticity have been examined in many types of experimental studies, but a unified picture on how multiple biochemical pathways collectively shape neocortical plasticity is missing. We built a biochemically detailed model of post-synaptic plasticity describing CaMKII, PKA, and PKC pathways and their contribution to synaptic potentiation or depression. We developed a statistical AMPA-receptor-tetramer model, which permits the estimation of the AMPA-receptor-mediated maximal synaptic conductance based on numbers of GluR1s and GluR2s predicted by the biochemical signalling model. We show that our model reproduces neuromodulator-gated spike-timing-dependent plasticity as observed in the visual cortex and can be fit to data from many cortical areas, uncovering the biochemical contributions of the pathways pinpointed by the underlying experimental studies. Our model explains the dependence of different forms of plasticity on the availability of different proteins and can be used for the study of mental disorder-associated impairments of cortical plasticity."
Reference:
1 . Mäki-Marttunen T, Iannella N, Edwards AG, Einevoll GT, Blackwell KT (2020) A unified computational model for cortical post-synaptic plasticity. Elife [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex spiking regular (RS) neuron;
Channel(s): I Calcium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s): Glutamate; Norephinephrine; Acetylcholine;
Simulation Environment: NEURON; NeuroRD;
Model Concept(s): Long-term Synaptic Plasticity;
Implementer(s): Maki-Marttunen, Tuomo [tuomomm at uio.no];
Search NeuronDB for information about:  I Calcium; Acetylcholine; Norephinephrine; Glutamate;
/
synaptic
L23PC
L23_PC_cADpyr229_3
synapses
mtype_map.tsv *
synapses.hoc *
synapses.tsv *
synconf.txt *
                            
0	L1_DAC
1	L1_NGC-DA
2	L1_NGC-SA
3	L1_HAC
4	L1_DLAC
5	L1_SLAC
6	L23_PC
7	L23_MC
8	L23_BTC
9	L23_DBC
10	L23_BP
11	L23_NGC
12	L23_LBC
13	L23_NBC
14	L23_SBC
15	L23_ChC
16	L4_PC
17	L4_SP
18	L4_SS
19	L4_MC
20	L4_BTC
21	L4_DBC
22	L4_BP
23	L4_NGC
24	L4_LBC
25	L4_NBC
26	L4_SBC
27	L4_ChC
28	L5_TTPC1
29	L5_TTPC2
30	L5_UTPC
31	L5_STPC
32	L5_MC
33	L5_BTC
34	L5_DBC
35	L5_BP
36	L5_NGC
37	L5_LBC
38	L5_NBC
39	L5_SBC
40	L5_ChC
41	L6_TPC_L1
42	L6_TPC_L4
43	L6_UTPC
44	L6_IPC
45	L6_BPC
46	L6_MC
47	L6_BTC
48	L6_DBC
49	L6_BP
50	L6_NGC
51	L6_LBC
52	L6_NBC
53	L6_SBC
54	L6_ChC

Loading data, please wait...