// genesis
/* FILE INFORMATION
GENESIS implementation by D. Beeman of the channel models described in
Alain Destexhe and Denis Par, Impact of network activity on the
integrative properties of neocortical pyramidal neurons in vivo.
Journal of Neurophysiology 81: 1531-1547, 1999
Some adjustments were made to represent the model in
Destexhe A, Rudolph M, Fellous JM and Sejnowski TJ.
Fluctuating synaptic conductances recreate in-vivo-like activity in
neocortical neurons. Neuroscience 107: 13-24, 2001.
Based on the NEURON demonstration 'FLUCT' by Alain Destexhe.
http://cns.iaf.cnrs-gif.fr
*/
// passive membrane parameters
float CM
float RA
float RM
// channel equilibrium potentials (V)
float EREST_ACT = -0.063 // value for vtraub in Destexhe et al. (2001)
// float EREST_ACT = -0.058 // value for vtraub in Destexhe and Par (1999)
float ENA = 0.050
float EK = -0.090
/* These channels use the setupalpha function to create tabchannel tables
to represent alpha and beta values in the form (A+B*V)/(C+exp((V+D)/F))
The first 6 arguments are the coefficients for alpha, and the last 6
are for beta
*/
//========================================================================
// Tabchannel Hippocampal fast Na channel
// Based on Traub, R. D. and Miles, R. Neuronal Networks of the hippocampus
// Cambridge University Press (1991)
//========================================================================
function make_Na_traub_mod
str chanpath = "Na_traub_mod"
if ({argc} == 1)
chanpath = {argv 1}
end
if (({exists {chanpath}}))
return
end
create tabchannel {chanpath}
setfield ^ \
Ek {ENA} \ // V
Ik 0 \ // A
Gk 0 \ // S
Xpower 3 \
Ypower 1 \
Zpower 0
setupalpha {chanpath} X \
{320e3 * (0.013 + EREST_ACT)} \
-320e3 -1.0 {-1.0 * (0.013 + EREST_ACT)} \
-0.004 \
{-280e3 * (0.040 + EREST_ACT)} \
280e3 \
-1.0 \
{-1.0 * (0.040 + EREST_ACT)} \
5.0e-3
// Traub and Miles Na inactivation was shifted by Destexhe and Par
// but this version uses no offset
// float offset = -0.010
float offset = 0.0
setupalpha {chanpath} Y \
128.0 \
0.0 \
0.0 \
{-1.0 * (0.017 + EREST_ACT + offset)} \
0.018 \
4.0e3 \
0.0 \
1.0 \
{-1.0 * (0.040 + EREST_ACT + offset)} \
-5.0e-3
end
//========================================================================
// Tabchannel K(DR) Hippocampal cell channel
// Based on Traub, R. D. and Miles, R. Neuronal Networks of the hippocampus
// Cambridge University Press (1991)
//========================================================================
function make_K_traub_mod
str chanpath = "K_traub_mod"
if ({argc} == 1)
chanpath = {argv 1}
end
if (({exists {chanpath}}))
return
end
create tabchannel {chanpath}
setfield ^ \
Ek {EK} \ // V
Ik 0 \ // A
Gk 0 \ // S
Xpower 4 \
Ypower 0 \
Zpower 0
setupalpha {chanpath} X \
{32e3 * (0.015 + EREST_ACT)} \
-32e3 \
-1.0 \
{-1.0 * (0.015 + EREST_ACT) } \
-0.005 \
500 \
0.0 \
0.0 \
{-1.0 * (0.010 + EREST_ACT) } \
0.04
end
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