ModelDB: Cortical Basal Ganglia Network Model during Closed-loop DBS (Fleming et al 2020)

Cortical Basal Ganglia Network Model during Closed-loop DBS (Fleming et al 2020)

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Model Information
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Citations

Accession:262046

We developed a computational model of the cortical basal ganglia network to investigate closed-loop control of deep brain stimulation (DBS) for Parkinson’s disease (PD). The cortical basal ganglia network model incorporates the (i) the extracellular DBS electric field, (ii) antidromic and orthodromic activation of STN afferent fibers, (iii) the LFP detected at non-stimulating contacts on the DBS electrode and (iv) temporal variation of network beta-band activity within the thalamo-cortico-basal ganglia loop. The model facilitates investigation of clinically-viable closed-loop DBS control approaches, modulating either DBS amplitude or frequency, using an LFP derived measure of network beta-activity.
Reference:
1 . Fleming JE, Dunn E, Lowery MM (2020) Simulation of Closed-Loop Deep Brain Stimulation Control Schemes for Suppression of Pathological Beta Oscillations in Parkinson’s Disease Frontiers in Neuroscience 14:166

Model Information (Click on a link to find other models with that property)

Model Type:	Realistic Network; Extracellular; Axon;
Brain Region(s)/Organism:	Basal ganglia; Neocortex;
Cell Type(s):	Hodgkin-Huxley neuron;
Channel(s):	I K; I Sodium; I Calcium; I_AHP; I L high threshold; I T low threshold;
Gap Junctions:
Receptor(s):	GabaA; AMPA;
Gene(s):
Transmitter(s):	Gaba; Glutamate;
Simulation Environment:	NEURON; Python; PyNN;
Model Concept(s):	Deep brain stimulation; Parkinson's; Beta oscillations; Activity Patterns; Extracellular Fields;
Implementer(s):	John E. Fleming, John E [john.fleming at ucdconnect.ie];

Search NeuronDB for information about: GabaA; AMPA; I L high threshold; I T low threshold; I K; I Sodium; I Calcium; I_AHP; Gaba; Glutamate;

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Cortex_BasalGanglia_DBS_model

Updated_PyNN_Files

readme.html

Cortical_Axon_I_Kd.mod

Cortical_Axon_I_Kv.mod

Cortical_Axon_I_Leak.mod

Cortical_Axon_I_Na.mod

Cortical_Soma_I_K.mod

Cortical_Soma_I_Leak.mod

Cortical_Soma_I_M.mod

Cortical_Soma_I_Na.mod

Destexhe_Static_AMPA_Synapse.mod

Destexhe_Static_GABAA_Synapse.mod

Interneuron_I_K.mod

Interneuron_I_Leak.mod

Cortical_Basal_Ganglia_Cell_Classes.py

cortical_collateral_electrode_distances.txt

cortical_xy_pos.txt

CorticalAxonInterneuron_Connections.txt

CorticalSomaThalamic_Connections.txt

CorticalSTN_Connections.txt

Electrode_Distances.py

Global_Variables.py

GPe_Stimulation_Order.txt

GPeGPe_Connections.txt

GPeGPi_Connections.txt *

GPeSTN_Connections.txt

GPiThalamic_Connections.txt

InterneuronCortical_Connections.txt

run_CBG_Model_Amplitude_Modulation_Controller.py

run_CBG_Model_Frequency_Modulation_Controller.py

run_CBG_Model_to_SS.py

STN_xy_pos.txt

STNGPe_Connections.txt

STNGPi_Connections.txt *

Striatal_Spike_Times.npy

StriatalGPe_Connections.txt

ThalamicCorticalSoma_Connections.txt

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