Survey of electrically evoked responses in the retina (Tsai et al 2017)

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Accession:262389
"Cones and horizontal cells are interconnected to adjacent cones and horizontal cells, respectively, with gap junctions. In particular, the horizontal cell gap junctional conductance is modulated by exogenous factors. What roles does this conductance play in the electrically evoked responses of horizontal cells? To address this question, we constructed a computational model consisting of the cone and horizontal cell layer..."
Reference:
1 . Tsai D, Morley JW, Suaning GJ, Lovell NH (2017) Survey of electrically evoked responses in the retina - stimulus preferences and oscillation among neurons. Sci Rep 7:13802 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse; Extracellular;
Brain Region(s)/Organism: Retina;
Cell Type(s): Retina photoreceptor cone GLU cell; Retina horizontal cell;
Channel(s):
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Oscillations;
Implementer(s): Tsai, David [d.tsai at unsw.edu.au];
Search NeuronDB for information about:  Retina photoreceptor cone GLU cell;
// Template for horizontal cells


begintemplate HzCell
    public init, soma, dendrite
    create soma, dendrite[8]  //N, E, S, W, & 4 diagonals

    public all, dendrites
    objref all, dendrites

    proc init() { local x, y, z
        // for specifying a network of cells
        if (numarg() == 3) {
            x = $1
            y = $2
            z = $3
        } else {
            x = 0
            y = 0
            z = 0
        }

        // topology
        soma {
            pt3dclear() pt3dadd(x-10, y, z, 1) pt3dadd(x, y, z, 1)}
        dendrite[0] { //N
            pt3dclear() pt3dadd(x-5, y+5, z, 1) pt3dadd(x-5, y+142, z, 1)}
        dendrite[1] { //E
            pt3dclear() pt3dadd(x, y, z, 1) pt3dadd(x+137, y, z, 1)}
        dendrite[2] { //W
            pt3dclear() pt3dadd(x-10, y, z, 1) pt3dadd(x-147, y, z, 1)}
        dendrite[3] { //S
            pt3dclear() pt3dadd(x-5, y-5, z, 1) pt3dadd(x-5, y-142, z, 1)}
        dendrite[4] { //NE
            pt3dclear() pt3dadd(x-2, y+1.4, z, 1) pt3dadd(x+94.9, y+99.8, z, 1)}
        dendrite[5] { //SE
            pt3dclear() pt3dadd(x-2, y-1.4, z, 1) pt3dadd(x+94.9, y-98.3, z, 1)}
        dendrite[6] { //NW
            pt3dclear() pt3dadd(x-8, y+1.4, z, 1) pt3dadd(x-104.9, y+99.8, z, 1)}
        dendrite[7] { //SW
            pt3dclear() pt3dadd(x-8, y-1.4, z, 1) pt3dadd(x-104.9, y-98.3, z, 1)}

        // geometry
        soma {
            L = 10
            diam = 10 
            // L = 58.0869
            // diam = 58.0869
            nseg = 1
        }
        for i = 0,7 {
            dendrite[i] {
                L = 137
                diam = 3
                nseg = 1
            }
        }
        for i = 0,7 connect dendrite[i](1), soma(0)
        
        // section list
        all = new SectionList()
        soma all.append()
        for i=0,7 dendrite[i] all.append()
        dendrites = new SectionList()
        for i=0,7 dendrite[i] dendrites.append()
        
        // biophysics
        forsec all {
            insert HzINa
            insert HzICa
            insert HzIKv
            insert HzIA
            insert HzIKa
            insert HzLeak
            ena = 55
            ek = -80
            el = -80
            Ra = 160
            cm = 1
        }
    }
endtemplate HzCell


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