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Electrodecrements in in vitro model of infantile spasms (Traub et al 2020)
 
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Model Information
Model File
Citations
Accession:
263705
The code is an extension of the thalamocortical model of Traub et al. (2005) J Neurophysiol. It is here applied to an in vitro model of the electrodecremental response seen in the EEG of children with infantile spasms (West syndrome)
References:
1 .
Traub RD, Moeller F, Rosch R, Baldeweg T, Whittington MA, Hall SP (2020) Seizure initiation in infantile spasms vs. focal seizures: proposed common cellular mechanisms.
Rev Neurosci
31
:181-200
[
PubMed
]
2 .
Hall S, Hunt M, Simon A, Cunnington LG, Carracedo LM, Schofield IS, Forsyth R, Traub RD, Whittington MA (2015) Unbalanced Peptidergic Inhibition in Superficial Neocortex Underlies Spike and Wave Seizure Activity.
J Neurosci
35
:9302-14
[
PubMed
]
3 .
Carracedo LM, Kjeldsen H, Cunnington L, Jenkins A, Schofield I, Cunningham MO, Davies CH, Traub RD, Whittington MA (2013) A neocortical delta rhythm facilitates reciprocal interlaminar interactions via nested theta rhythms.
J Neurosci
33
:10750-61
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Realistic Network;
Brain Region(s)/Organism:
Thalamus;
Neocortex;
Cell Type(s):
Thalamus geniculate nucleus/lateral principal GLU cell;
Thalamus reticular nucleus GABA cell;
Neocortex U1 L6 pyramidal corticalthalamic GLU cell;
Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell;
Neocortex layer 4 pyramidal cell;
Neocortex fast spiking (FS) interneuron;
Neocortex spiking regular (RS) neuron;
Neocortex spiking low threshold (LTS) neuron;
Neocortex spiny stellate cell;
Channel(s):
I Na,p;
I Na,t;
I L high threshold;
I A;
I K;
I M;
I h;
I K,Ca;
I Calcium;
I A, slow;
Gap Junctions:
Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:
FORTRAN;
Model Concept(s):
Brain Rhythms;
Epilepsy;
Implementer(s):
Traub, Roger D [rtraub at us.ibm.com];
Search NeuronDB
for information about:
Thalamus geniculate nucleus/lateral principal GLU cell
;
Thalamus reticular nucleus GABA cell
;
Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell
;
Neocortex U1 L6 pyramidal corticalthalamic GLU cell
;
I Na,p
;
I Na,t
;
I L high threshold
;
I A
;
I K
;
I M
;
I h
;
I K,Ca
;
I Calcium
;
I A, slow
;
/
plateauVFO11
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