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Electrodecrements in in vitro model of infantile spasms (Traub et al 2020)
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Model Information
Model File
Citations
Accession:
263705
The code is an extension of the thalamocortical model of Traub et al. (2005) J Neurophysiol. It is here applied to an in vitro model of the electrodecremental response seen in the EEG of children with infantile spasms (West syndrome)
References:
1 .
Traub RD, Moeller F, Rosch R, Baldeweg T, Whittington MA, Hall SP (2020) Seizure initiation in infantile spasms vs. focal seizures: proposed common cellular mechanisms.
Rev Neurosci
31
:181-200
[
PubMed
]
2 .
Hall S, Hunt M, Simon A, Cunnington LG, Carracedo LM, Schofield IS, Forsyth R, Traub RD, Whittington MA (2015) Unbalanced Peptidergic Inhibition in Superficial Neocortex Underlies Spike and Wave Seizure Activity.
J Neurosci
35
:9302-14
[
PubMed
]
3 .
Carracedo LM, Kjeldsen H, Cunnington L, Jenkins A, Schofield I, Cunningham MO, Davies CH, Traub RD, Whittington MA (2013) A neocortical delta rhythm facilitates reciprocal interlaminar interactions via nested theta rhythms.
J Neurosci
33
:10750-61
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Realistic Network;
Brain Region(s)/Organism:
Thalamus;
Neocortex;
Cell Type(s):
Thalamus geniculate nucleus/lateral principal GLU cell;
Thalamus reticular nucleus GABA cell;
Neocortex U1 L6 pyramidal corticalthalamic GLU cell;
Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell;
Neocortex layer 4 pyramidal cell;
Neocortex fast spiking (FS) interneuron;
Neocortex spiking regular (RS) neuron;
Neocortex spiking low threshold (LTS) neuron;
Neocortex spiny stellate cell;
Channel(s):
I Na,p;
I Na,t;
I L high threshold;
I A;
I K;
I M;
I h;
I K,Ca;
I Calcium;
I A, slow;
Gap Junctions:
Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:
FORTRAN;
Model Concept(s):
Brain Rhythms;
Epilepsy;
Implementer(s):
Traub, Roger D [rtraub at us.ibm.com];
Search NeuronDB
for information about:
Thalamus geniculate nucleus/lateral principal GLU cell
;
Thalamus reticular nucleus GABA cell
;
Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell
;
Neocortex U1 L6 pyramidal corticalthalamic GLU cell
;
I Na,p
;
I Na,t
;
I L high threshold
;
I A
;
I K
;
I M
;
I h
;
I K,Ca
;
I Calcium
;
I A, slow
;
/
plateauVFO11
readme.txt
dexptablebig_setup.f
*
Other models using dexptablebig_setup.f:
A single column thalamocortical network model (Traub et al 2005)
Alpha rhythm in vitro visual cortex (Traub et al 2020)
dexptablesmall_setup.f
*
Other models using dexptablesmall_setup.f:
A single column thalamocortical network model (Traub et al 2005)
Alpha rhythm in vitro visual cortex (Traub et al 2020)
durand.f
*
Other models using durand.f:
A single column thalamocortical network model (Traub et al 2005)
Alpha rhythm in vitro visual cortex (Traub et al 2020)
fnmda.f
*
Other models using fnmda.f:
A single column thalamocortical network model (Traub et al 2005)
Alpha rhythm in vitro visual cortex (Traub et al 2020)
gettime.c
*
Other models using gettime.c:
Alpha rhythm in vitro visual cortex (Traub et al 2020)
groucho_gapbld.f
*
Other models using groucho_gapbld.f:
A single column thalamocortical network model (Traub et al 2005)
Alpha rhythm in vitro visual cortex (Traub et al 2020)
groucho_gapbld_mix.f
*
Other models using groucho_gapbld_mix.f:
A single column thalamocortical network model (Traub et al 2005)
Alpha rhythm in vitro visual cortex (Traub et al 2020)
integrate_deepaxaxx.f
*
Other models using integrate_deepaxaxx.f:
Alpha rhythm in vitro visual cortex (Traub et al 2020)
integrate_deepbaskx.f
*
Other models using integrate_deepbaskx.f:
Alpha rhythm in vitro visual cortex (Traub et al 2020)
integrate_deepLTSx.f
*
Other models using integrate_deepLTSx.f:
Alpha rhythm in vitro visual cortex (Traub et al 2020)
integrate_deepng.f
*
Other models using integrate_deepng.f:
Alpha rhythm in vitro visual cortex (Traub et al 2020)
integrate_nrtxB.f
*
Other models using integrate_nrtxB.f:
Alpha rhythm in vitro visual cortex (Traub et al 2020)
integrate_spinstelldiegoxB.f
*
Other models using integrate_spinstelldiegoxB.f:
Alpha rhythm in vitro visual cortex (Traub et al 2020)
integrate_supaxaxx.f
*
Other models using integrate_supaxaxx.f:
Alpha rhythm in vitro visual cortex (Traub et al 2020)
integrate_supbaskx.f
*
Other models using integrate_supbaskx.f:
Alpha rhythm in vitro visual cortex (Traub et al 2020)
integrate_supLTSX.f
*
Other models using integrate_supLTSX.f:
Alpha rhythm in vitro visual cortex (Traub et al 2020)
integrate_supng.f
*
Other models using integrate_supng.f:
Alpha rhythm in vitro visual cortex (Traub et al 2020)
integrate_suppyrFRBxPB.f
*
Other models using integrate_suppyrFRBxPB.f:
Alpha rhythm in vitro visual cortex (Traub et al 2020)
integrate_tcrxB.f
*
Other models using integrate_tcrxB.f:
Alpha rhythm in vitro visual cortex (Traub et al 2020)
integrate_tuftRSXXB.f
*
Other models using integrate_tuftRSXXB.f:
Alpha rhythm in vitro visual cortex (Traub et al 2020)
makefile
otis.f
*
Other models using otis.f:
Alpha rhythm in vitro visual cortex (Traub et al 2020)
otis_table_setup.f
*
Other models using otis_table_setup.f:
Alpha rhythm in vitro visual cortex (Traub et al 2020)
plateauVFO.f
plateauVFO11.nontuftRS
plateauVFO11.pdf
plateauVFO11.suppyrRS
plateauVFO11.tuftIB
synaptic_compmap_construct.f
*
Other models using synaptic_compmap_construct.f:
A single column thalamocortical network model (Traub et al 2005)
Alpha rhythm in vitro visual cortex (Traub et al 2020)
synaptic_map_construct.f
*
Other models using synaptic_map_construct.f:
A single column thalamocortical network model (Traub et al 2005)
Alpha rhythm in vitro visual cortex (Traub et al 2020)
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