Neural recruitment during synchronous multichannel microstimulation (Hokanson et al 2018)

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" ...The effects of field interactions on neuronal recruitment depend on several factors, which have been studied extensively at the macro-scale but have been overlooked in the case of high density arrays. Here, we report that field interactions can significantly affect neural recruitment, even with low amplitude stimulation. We created a computational model of peripheral nerve axons to estimate stimulation parameters sufficient to generate neural recruitment during synchronous and asynchronous stimulation on two microelectrodes located within the peripheral nerve. Across a range of stimulus amplitudes, the model predicted that synchronous stimulation on adjacent electrodes (400 µm separation), would recruit 2-3 times more neurons than during asynchronous stimulation. ..."
1 . Hokanson JA, Gaunt RA, Weber DJ (2018) Effects of Synchronous Electrode Pulses on Neural Recruitment During Multichannel Microstimulation. Sci Rep 8:13067 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Axon;
Brain Region(s)/Organism:
Cell Type(s):
Gap Junctions:
Simulation Environment: NEURON (web link to model); MATLAB (web link to model);
Model Concept(s): Action Potentials;
Implementer(s): Hokanson, James A. [jim.hokanson at];
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