Library of biophysically detailed striatal projection neurons (Lindroos and Hellgren Kotaleski 2020)

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Accession:266775
Library of compartmentalized models used to investigate dendritic integration in striatal projection neurons under neuromodulation.
Reference:
1 . Lindroos R, Hellgren Kotaleski J (2020) Predicting complex spikes in striatal projection neurons of the direct pathway following neuromodulation by acetylcholine and dopamine. Eur J Neurosci [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Synapse;
Brain Region(s)/Organism: Striatum; Hippocampus; Basal ganglia;
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; Striatal projection neuron;
Channel(s): I M; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s): Acetylcholine; Dopamine;
Simulation Environment: NEURON; Python;
Model Concept(s): Active Dendrites; Detailed Neuronal Models; Neuromodulation; Synaptic Plasticity; Activity Patterns; Soma-dendrite cross-talk;
Implementer(s): Lindroos, Robert [robert.lindroos at ki.se]; Filipovic, Marko;
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; I M; I Potassium; Acetylcholine; Dopamine;
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lib
mechanisms
single
bk.mod *
cadyn.mod *
cal12.mod
cal13.mod
caldyn.mod *
can.mod
car.mod
cav32.mod
cav33.mod
gaba.mod
glutamate.mod
Im.mod *
kaf.mod
kas.mod
kdr.mod *
kir.mod
naf.mod
sk.mod
vecevent.mod *
                            
TITLE BK-type calcium activated K channel

UNITS {
    (molar) = (1/liter)
    (mV) = (millivolt)
    (mA) = (milliamp)
    (mM) = (millimolar)
    FARADAY = (faraday) (kilocoulombs)
    R = (k-mole) (joule/degC)
}

NEURON {
    SUFFIX bk
    USEION ca READ cai
    USEION k READ ek WRITE ik
    RANGE gbar, ik
}

PARAMETER {
    gbar = 0.0 (mho/cm2)
    k1 = 0.180 (mM)
    k4 = 0.011 (mM)
}

ASSIGNED {
    v (mV)
    ik (mA/cm2)
    celsius (degC)
    cai (mM) 
    ek (mV)
    oinf
    otau (ms)
}

STATE { o }

BREAKPOINT {
    SOLVE state METHOD cnexp
    ik = gbar*o*(v-ek)
}

DERIVATIVE state {
    rate(v, cai)
    o' = (oinf-o)/otau
}

INITIAL {
    rate(v, cai)
    o = oinf
}

PROCEDURE rate(v (mV), ca (mM)) {
    LOCAL a, b, sum, z
    UNITSOFF
    z = 1e-3*2*FARADAY/(R*(celsius+273.15))
    a = 0.48*ca/(ca+k1*exp(-0.84*z*v))
    b = 0.28/(1+ca/(k4*exp(-z*v)))
    sum = a+b
    oinf = a/sum
    otau = 1/sum
    UNITSON
}

COMMENT

Original model by Moczydlowski (1983), rat skeletal muscle.

Genesis implementation by De Schutter, adapted by Kai Du.

Revision by Evans (2012, 2013), K1 changed from 0.180 to 0.003 and K4
from 0.011 to 0.009, according to Berkefeld (2006), Xenopus oocytes.

NEURON implementation by Alexander Kozlov <akozlov@csc.kth.se>.

ENDCOMMENT

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