Cerebellar Golgi cells, dendritic processing, and synaptic plasticity (Masoli et al 2020)

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Accession:266806
The Golgi cells are the main inhibitory interneurons of the cerebellar granular layer. To study the mechanisms through which these neurons integrate complex input patterns, a new set of models were developed using the latest experimental information and a genetic algorithm approach to fit the maximum ionic channel conductances. The models faithfully reproduced a rich pattern of electrophysiological and pharmacological properties and predicted the operating mechanisms of these neurons.
Reference:
1 . Masoli S, Ottaviani A, Casali S, D'Angelo E (2020) Cerebellar Golgi cell models predict dendritic processing and mechanisms of synaptic plasticity. PLoS Comput Biol 16:e1007937 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Cerebellum;
Cell Type(s): Cerebellum golgi cell;
Channel(s): I Sodium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Neurotransmitter dynamics; Calcium dynamics;
Implementer(s): Masoli, Stefano [stefano.masoli at unipv.it];
Search NeuronDB for information about:  I Sodium;
 
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Golgi_cell_2020
                            
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